Solanum nigrum show anti-obesity effects on high-fat diet-fed Sprague Dawley rats in a randomized study

Nderitu, Kathryn Wanjiku; Mecha, Ezekiel; Nyachieo, Atunga

doi:10.1016/j.sciaf.2023.e01713

Cited by 1 publication

(2 citation statements)

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“…Numerous studies have highlighted the bioactive compounds present in Solanum plants, which demonstrate anti-diabetic properties by promoting insulin sensitivity and reducing blood glucose levels [6,7]. Research has indicated that certain compounds in Solanum plants can inhibit fat accumulation, promote lipid metabolism, and suppress one's appetite, making them valuable candidates in the fight against obesity [8][9][10]. Studies have revealed that extracts from certain Solanum species, such as Solanum nigrum, exhibit significant antioxidant properties due to their content of flavonoids and polyphenols [11].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Profile, Antilipase, Hemoglobin Antiglycation, Antihyperglycemic, and Anti-Inflammatory Activities of Solanum elaeagnifolium Cav.

Bouslamti,

Elrherabi,

Loukili

et al. 2023

Applied Sciences

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In the present investigation, the phenolic compounds of Solanum elaeagnifolium were identified, and the plant’s anti-lipase and anti-glycation effects on hemoglobin were discovered through in vitro experiments, as well as its short-term antihyperglycemic and anti-inflammatory effects. The chemical compound composition was detected using HPLC-DAD, the anti-lipase activity was tested in vitro using 4-nitrophenyl butyrate as a substrate, and the antiglycation activity of the plant extracts was also tested in vitro using a haemoglobin model. The antihyperglycemic effect was determined by inhibiting pancreatic α-amylase and α-glycosidase activity and performing an in vivo glucose tolerance test on normal rats, and the anti-inflammatory activity was determined by inducing paw inflammation with carrageenan. In both the SEFR (fruit) and SEFE (leaf) extracts, chromatographic analysis revealed the presence of quercetin 3-O-β-D-glucoside, rutin, and quercetin. SEFR inhibited the pancreatic lipase enzyme more effectively, with an IC50 of 0.106 ± 0.00 mg/mL. S. elaeagnifolium extracts demonstrated significant antiglycation activity, with 3.990 ± 0.23 mg/mL of SEFE and 3.997 ± 0.14 mg/mL of SEFR. When compared to positive and negative controls, plant extracts had very significant anti-diabetic and anti-inflammatory effects. The findings in this study and previous research on this plant encourage us to investigate other pharmacological activities of this plant besides its duiretic, cictrisant, and anti-ulcer activity.

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Section: Introductionmentioning

confidence: 99%

“…Figure 1. HPLC-DAD chromatogram of S. elaeagnifolium extracts at 254 nm (fruits (SEFR) and leaves (SEFE)) and identified with the standards (catechin (1), vanillin (2), naringin (3), quercetin 3-O-β-Dglucoside (4), rutin (5), cinnamic acid (6), p-coumaric acid(7), quercetin(8), trans-3-hydroxycinnamic acid (9), kaempferol(10), and flavone(11)). …”

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confidence: 99%