Sole infection by human metapneumovirus among children with radiographically diagnosed community-acquired pneumonia in a tropical region

Nascimento‐Carvalho, Cristiana M.; Cardoso, Maria Regina Alves; Ruuskanen, Olli; Lappalainen, Maija

doi:10.1111/j.1750-2659.2011.00206.x

Cited by 21 publications

(19 citation statements)

References 10 publications

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“…The results show that hMPV plays an important role in pediatric community-acquired pneumonia in Beijing, China, as hMPV infections accounted for 6.3% of the cases from July 2008 through June 2010. hMPV was detected at a lower rate in Beijing than in a study population less than 5 years old in Israel (8.3%) [Wolf et al, 2010] and in a study population less than 3 years old in Spain (11.5%) [Cilla et al, 2008]. However, the hMPV detection rate in Beijing was higher than that reported in Brazil (4.1%) for children younger than 5 years old [Nascimento-Carvalho et al, 2011]. It was also higher than that in Nepal for children less than 3 years old (4.2%) [Mathisen et al, 2010], and that in Taiwan, China for children less than 5 years old (5.2%) [Lin et al, 2005].…”

Section: Discussioncontrasting

confidence: 52%

“…Since its discovery, hMPV has been recognized as a major cause of lower respiratory tract infections in children worldwide [Stockton et al, 2002;Boivin et al, 2003;Maggi et al, 2003;Peiris et al, 2003;Esper et al, 2004;Mullins et al, 2004;Williams et al, 2004;García-García et al, 2006;Caracciolo et al, 2008;Kim et al, 2010]. It accounts for 4.1-11.5% of pediatric community-acquired pneumonia cases, depending on geographical location, year, and subjects studied [Lin et al, 2005;Cilla et al, 2008;Mathisen et al, 2010;Wolf et al, 2010;Nascimento-Carvalho et al, 2011]. Although pneumonia is the leading cause of death in children less than 5 years old in China [Rudan et al, 2010], the etiology of pneumonia is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Human metapneumovirus associated with community‐acquired pneumonia in children in Beijing, China

Lu¹,

Li²,

Xie³

et al. 2012

Journal of Medical Virology

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Community-acquired pneumonia is a major cause of morbidity and mortality in children worldwide. However, few studies have been conducted on the infection of human metapneumovirus (hMPV) associated with pediatric community-acquired pneumonia in China. Nasopharyngeal aspirates were collected between July 2008 and June 2010 from 1,028 children, aged ≤16.5 years, who were diagnosed with community-acquired pneumonia in Beijing, China. Reverse-transcriptase polymerase chain reaction was used to screen the samples for hMPV and common respiratory viruses. hMPV was detected in 6.3% of the patients with community-acquired pneumonia. This detection rate is the third highest for a respiratory virus in children with community-acquired pneumonia, after that of rhinovirus (30.9%) and respiratory syncytial virus (30.7%). The detection rate of hMPV in 2008/2009 (42/540, 7.8%) was significantly higher than in 2009/2010 (23/488, 4.7%; χ(2) = 4.065, P = 0.044). The hMPV subtypes A2, B1, and B2 were found to co-circulate, with A2 being most prevalent. These results indicate that hMPV plays a substantial role in pediatric community-acquired pneumonia in China. Overall, these findings provide a better understanding of the epidemiological and clinical features of hMPV infections.

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Section: Discussioncontrasting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Human metapneumovirus associated with community‐acquired pneumonia in children in Beijing, China

Lu¹,

Li²,

Xie³

et al. 2012

Journal of Medical Virology

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“…Several reports have described some of the radiographic features of HMPV infection [24–27]; however most of these included fewer subjects, comprised retrospective convenience samples, or did not systematically evaluate radiographs. One report of 11 chest radiographs in children with radiologically diagnosed community-acquired pneumonia caused by HMPV described pulmonary infiltrates (alveolar or interstitial), hyperinflation and atelectasis [28]. Another report of chest CT findings in immunocompromised adults with HMPV reported asymmetrical pulmonary findings consisting of ground-glass opacity, airspace consolidation or bronchial wall thickening, in contrast to more symmetrical bilateral pulmonary infiltrates in immunocompromised adults with RSV-pneumonia [29].…”

Section: Discussionmentioning

confidence: 99%

Chest radiographic features of human metapneumovirus infection in pediatric patients

et al. 2017

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Background Human metapneumovirus (HMPV) was identified in 2001 and is a common cause of acute respiratory illness in young children. The radiologic characteristics of laboratory-confirmed HMPV acute respiratory illness in young children have not been systematically assessed. Objective We systematically evaluated the radiographic characteristics of acute respiratory illness associated with HMPV in a prospective cohort of pediatric patients. Materials and methods We included chest radiographs from children <5 years old with acute respiratory illness who were enrolled in the prospective New Vaccine Surveillance Network (NVSN) study from 2003 to 2009 and were diagnosed with HMPV by reverse transcription-polymerase chain reaction (RT-PCR). Of 215 HMPV-positive subjects enrolled at our tertiary care children’s hospital, 68 had chest radiographs obtained by the treating clinician that were available for review. Two fellowship-trained pediatric radiologists, independently and then in consensus, retrospectively evaluated these chest radiographs for their radiographic features. Results Parahilar opacities were the most commonly observed abnormality, occurring in 87% of children with HMPV. Hyperinflation also occurred frequently (69%). Atelectasis (40%) and consolidation (18%) appeared less frequently. Pleural effusion and pneumothorax were not seen on any radiographs. Conclusion The clinical presentations of HMPV include bronchiolitis, croup and pneumonia. Dominant chest radiographic abnormalities include parahilar opacities and hyperinflation, with occasional consolidation. Recognition of the imaging patterns seen with common viral illnesses like respiratory syncytial virus (RSV) and HMPV might facilitate diagnosis and limit unnecessary antibiotic treatment.

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“…Therefore we performed a post hoc sensitivity analysis in which only studies involving these viral infections were included [1],[2].…”

Section: Methodsmentioning

confidence: 99%

“…While respiratory syncytial virus (RSV), influenza (INF) and human metapneumovirus (hMPV) have been mainly identified amongst children with single viral infections, other viruses including adenovirus (ADV), coronavirus and human rhinovirus (HRV) have been mainly reported amongst children with viral co-infections [2].…”

Section: Introductionmentioning

confidence: 99%

Clinical Disease Severity of Respiratory Viral Co-Infection versus Single Viral Infection: A Systematic Review and Meta-Analysis

Asner¹,

Tran

Śmieja³

et al. 2014

PLoS ONE

148

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BackgroundResults from cohort studies evaluating the severity of respiratory viral co-infections are conflicting. We conducted a systematic review and meta-analysis to assess the clinical severity of viral co-infections as compared to single viral respiratory infections.MethodsWe searched electronic databases and other sources for studies published up to January 28, 2013. We included observational studies on inpatients with respiratory illnesses comparing the clinical severity of viral co-infections to single viral infections as detected by molecular assays. The primary outcome reflecting clinical disease severity was length of hospital stay (LOS). A random-effects model was used to conduct the meta-analyses.ResultsTwenty-one studies involving 4,280 patients were included. The overall quality of evidence applying the GRADE approach ranged from moderate for oxygen requirements to low for all other outcomes. No significant differences in length of hospital stay (LOS) (mean difference (MD) −0.20 days, 95% CI −0.94, 0.53, p = 0.59), or mortality (RR 2.44, 95% CI 0.86, 6.91, p = 0.09) were documented in subjects with viral co-infections compared to those with a single viral infection. There was no evidence for differences in effects across age subgroups in post hoc analyses with the exception of the higher mortality in preschool children (RR 9.82, 95% CI 3.09, 31.20, p<0.001) with viral co-infection as compared to other age groups (I2 for subgroup analysis 64%, p = 0.04).ConclusionsNo differences in clinical disease severity between viral co-infections and single respiratory infections were documented. The suggested increased risk of mortality observed amongst children with viral co-infections requires further investigation.

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Sole infection by human metapneumovirus among children with radiographically diagnosed community-acquired pneumonia in a tropical region

Cited by 21 publications

References 10 publications

Human metapneumovirus associated with community‐acquired pneumonia in children in Beijing, China

Human metapneumovirus associated with community‐acquired pneumonia in children in Beijing, China

Chest radiographic features of human metapneumovirus infection in pediatric patients

Clinical Disease Severity of Respiratory Viral Co-Infection versus Single Viral Infection: A Systematic Review and Meta-Analysis

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