Solid Adenosquamous Carcinoma of the Liver A Case Report and Review of the Literature

Hamaya, Kazuo; Nose, Soichiro; Mimura, Tetsushige; Sasaki, Kiyoshi

doi:10.1111/j.1440-1827.1991.tb01627.x

Cited by 16 publications

(24 citation statements)

References 17 publications

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“…This tumor is considered to be a subtype of cholangiocarcinoma, whichis not a common type of liver malignancy. However, the histogenesis of the tumor is still largely unknown.Someinvestigators support the theory that the tumor might develop by transformation of pre-existing adenocarcinoma in the transitional areas between adenocarcinoma and squamous cell carcinoma (5,6). Concerning the pathogenesis, somereports have demonstrated that ASCis associated with hepatolithiasis (7,8) Concerning the biological relationship of G-CSF and tumor growth, it has been reported that G-CSFalso stimulates nonhematopoietic tumor cells.…”

Section: Introductionmentioning

confidence: 97%

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

et al. 2001

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A 55-year-old man was admitted to our hospital with fever and vomiting. Abdominal computed tomography (CT) revealed multiple low density masses in the liver. A diagnosis of primary adenosquamouscarcinoma of the liver was confirmed by histological examination of a necropsy specimen. The present case showed leukocytosis and hypercalcemia with high levels of serum granulocyte-colony-stimulating factor (G-CSF) and parathyroid hormone related

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Section: Introductionmentioning

confidence: 97%

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

et al. 2001

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“…3 In addition, a review of the literature dealing with primary adenosquamous carcinoma of the liver showed some reported cases to demonstrate a huge solid tumor with extensive central necrosis. 14,15 In our case, the local effects were strongly suggested to be causative, because the autopsy findings did not indicate an apparent regrowth of the liver tumors despite his death due to development of cancerous peritonitis. We assumed that the biological characteristic of adenosquamous cell carcinoma or an interruption of the blood supply caused by the remarkable swelling of hepatic hilar lymph nodes led to extensive tumor necrosis and could be one possible cause of the regression observed in our case.…”

Section: Discussionmentioning

confidence: 86%

Spontaneous Regression of a Metastatic Liver Tumor: Report of a Case

et al. 2002

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A 60-year-old man, who suffered from advanced rectal cancer accompanied with liver metastasis, underwent an abdominoperineal resection and a partial hepatectomy. He remained well until 4 months after surgery when he developed a biopsy-proven recurrent intrapelvic mass and multiple liver tumors. At 6 months after surgery, the metastatic liver tumors grew larger and almost completely occupied both lobes of the liver. However, 9 months after surgery, the liver tumors regressed remarkably and his clinical condition improved without any specific treatment for cancer. Although he died of cancerous peritonitis 18 months after surgery, the autopsy findings did not indicate any apparent regrowth of the liver tumors. To date, only one case report of a spontaneous regression of a metastatic liver tumor from colorectal cancer has been published in the English literature. We herein describe this rare case and discuss some of the reasons potentially responsible for the regression.

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“…1,2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] The preoperative diagnosis was extremely difficult, with only three patients correctly diagnosed by aspiration cytology.…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the liver: case report

Suzuki

Hirai

Ota

et al. 2002

Journal of Hepato-Biliary-Pancreatic Surgery

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We describe a case of adenosquamous carcinoma of the liver, including treatment for the recurrence. A 67-year-old man with prolonged high fever was diagnosed with a mass lesion in the left lobe of the liver seen by imaging studies. That mass lesion was histologically diagnosed as cholangiocarcinoma by needle biopsy. Left hepatic lobectomy was performed, and a tumor was found that measured 8.0 x 7.0 x 6.0 cm. It was a yellowish white solid mass without macroscopic invasion of the intrahepatic bile duct. Histological examination of the resected specimen revealed both adenocarcinoma and squamous cell carcinoma. The postoperative course was uneventful, but abdominal computed tomography 3 months after operation revealed seven masses in the remnant liver. We diagnosed recurrence of the tumor, and intrahepatic arterial infusion of cisplatin and 5-fluorouracil was begun. A partial remission resulted. Progression-free survival after chemotherapy lasted 2 months. However, the tumor markers and remnant tumor size increased gradually 9 months after the operation, and he died 14 months after surgery. We also review 41 cases of adenosquamous carcinoma of the liver reported in the Japanese and English language literature, including the present case.

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Solid Adenosquamous Carcinoma of the Liver A Case Report and Review of the Literature

Cited by 16 publications

References 17 publications

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

Primary Adenosquamous Carcinoma of the Liver Which Produces Granulocyte-Colony-Stimulating Factor and Parathyroid Hormone Related Protein: Association with Leukocytosis and Hypercalcemia.

Spontaneous Regression of a Metastatic Liver Tumor: Report of a Case

Primary adenosquamous carcinoma of the liver: case report

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