Solid and papillary epithelial neoplasm of the pancreas

Abstract

Solid and papillary epithelial (SPEN) is an uncommon pancreatic tumor often seen in young females. Although most of these neoplasms have a benign course, SPEN do have malignant potential. Treatment is surgical which is usually feasible either via enucleation or more radical procedures. Below we discuss diagnosis, treatment, and prognosis in detail.

Enucleation of non-invasive tumors in the proximal pancreas: indications and outcomes compared with standard resections

“…* P<0.05 vs. tumor size ≤3 cm of most benign and low-grade malignant tumors and their predilection for the young or middle-aged population (Valsangkar et al, 2012), patients could benefit more from parenchyma sparing and "no gastrointestinal tract disturbance" surgical procedures such as tumor EU. EU, first reported in 1898 by Ernesto Tricomi (Howard and Hess, 2002), has been widely accepted as an alternative procedure for benign and low-grade malignant pancreatic tumors including endocrine tumors (Ramage et al, 2005;Norton, 2006;Crippa et al, 2007;Falconi et al, 2010;Hackert et al, 2011;Zhang et al, 2013), SCAs, MCNs, SPTs, branch-duct IPMNs, pseudocysts, and so forth (Talamini et al, 1998;Kiely et al, 2003;Madan et al, 2004;Papavramidis and Papavramidis, 2005;Crippa et al, 2007;Ge et al, 2010;Hackert et al, 2011;Turrini et al, 2011;Zhang et al, 2013). EU has proved to be a procedure characterized by less operation time and blood loss, faster recovery, and preserving more of the pancreas parenchyma, compared with standard procedures (Casadei et al, 2010;Falconi et al, 2010;Hackert et al, 2011;Yan et al, 2015).…”

Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: A case report and review of the literature

“…We observed 8 SPTs among a total of 282 (2.8%) cystic tumors of the pancreas from 1986 to 2006 (Table 1). SPT is generally considered a tumor with a low malignant potential, usually occurring in young females in their second or third decade of life [2,4] . Although resection of the tumor provides a 5-year survival rate of 97%, local recurrence or distant metastases can occur in a significant number of patients [4] .…”

“…SPT is generally considered a tumor with a low malignant potential, usually occurring in young females in their second or third decade of life [2,4] . Although resection of the tumor provides a 5-year survival rate of 97%, local recurrence or distant metastases can occur in a significant number of patients [4] . Moreover, in a minority of patients a locally advanced or metastatic disease is discovered at their initial presentation, as in our 49-year-old patient.…”

“…Recurrence after apparently radical resection of a SPT can occur in 10%-15% of cases, and the liver is the most common site [2][3][4]16,29] (Table 3). Resection of liver metastases is possible if liver involvement is limited [16,23,32,34,36,37] .…”

A Second Relapse of a Solid Pseudopapillary Tumor of the Pancreas: Case Description

“…In most cases, the prognosis in SPT is favorable; 97% of patients experience a 5-year period free from relapse after a radical surgery (13). According to the data from the literature, however, metastases of SPT mainly to the liver, peritoneum, and rarely regional lymph nodes can be seen in 15% of patients.…”