Solid Dispersions of Nitrofurantoin, Ethotoin, and Coumarin with Polyethylene Glycol 6000 and Their Coprecipitates with Povidone 25,000

Poly(ethylene) glycols and mechanochemistry for the preparation of bioactive 3,5-disubstituted hydantoins

“…It was reported that solid dispersion of ethotoin 12 in PEG solvent displayed improved solubility and diffusion properties. 44 At a molecular level, this was explained by the existence of hydrogen bonding NH / O between the amide and the polyether chain. 45 Similar interactions can be evoked with 5-phenyl hydantoin 30 (Method C) or ureido derivative A (Methods A and B).…”

Enhanced solubility and dissolution rate of lamotrigine by inclusion complexation and solid dispersion technique

“…The rapid dissolution of lamotrigine from solid dispersions may be attributed to a decrease in the crystallinity of drug and its molecular and colloidal dispersion in the hydrophilic carrier matrix. As the soluble carrier dissolves, the insoluble drug gets exposed to dissolution medium in the form of very fine particles for quick dissolution (Geneidi et al 1978;Save & Venkitachalam 1992). The enhancement in drug dissolution from the lamotrigine-PVP K30 (1:5) solid dispersion systems was higher than from the all other binary systems of PVP K30, bCD and PEG 6000, showing the importance of the proper choice of carrier.…”

Dissolution, Stability, and Absorption Characteristics of Dicumarol in Polyethylene Glycol 4000 Solid Dispersions

“…The dissolution of prednisolone, methyltestosterone, hydrocortisone, and digitoxin has been enhanced by polyethylene glycol fusion dispersions (7). Similarly, enhanced dissolution rates of griseofulvin (2,8), nitrofurantoin, ethotoin, and coumarin (13) in polymer melt systems were reported.…”