Solid Dispersions of α-Mangostin Improve Its Aqueous Solubility through Self-Assembly of Nanomicelles

Aisha, Abdalrahim F. A.; Ismail, Zhari; Abu‐Salah, Khalid M.; Majid, Amin Malik Shah Abdul

doi:10.1002/jps.22806

Cited by 90 publications

(95 citation statements)

References 30 publications

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“…They are classified into polyphenolic compounds and have been reported to have high antioxidant activities [2][3][4]. Some delivery methods to improve the bioavailability of -mangostin have recently been studied, including microgel [5], solid dispersion [6], microsphere [7], and nanofiber mat [8].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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Nanofiber mats of polyvinyl(pyrrolidone) (PVP) with Garcinia mangostana extract (GME) as the encapsulated drug have been developed using electrospinning. SEM images of all electrospun PVP/GME composite nanofiber mats showed that they had similar and smooth morphology, no beads, and spindle shape. Its average diameter decreased and its surface area therefore increased with the decrease of its PVP concentration. The benefit of high surface area is obvious in drug delivery systems for poorly water-soluble drugs. Their FTIR spectra indicated that PVP and GME interacted intermolecularly via hydrogen bonds in the composite nanofiber mats. A conformational change in the C-H chain of PVP occurred in the composite nanofiber mats due to the intermolecular interactions. Their XRD patterns confirmed that they were amorphous because of amorphization during electrospinning. The XRD analyses also strengthened the FTIR studies; namely, GME and PVP formed intermolecular interactions in the electrospun composite nanofiber mats. As a result, GME as the encapsulated drug was molecularly dispersed in the electrospun PVP nanofiber matrix that functioned as a drug delivery system. From the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the composite nanofiber mats exhibited very high antioxidant activities despite having been exposed to high voltage during electrospinning. Therefore, they are potential antioxidant products for food and pharmaceutics.

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Section: Introductionmentioning

confidence: 99%

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Sriyanti

Edikresnha

Rahma

et al. 2017

Journal of Nanomaterials

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“…GME is a hydrophobic molecule that is suitable for efficient encapsulation into cellulose-derivative nanoparticles. 18,19 The morphology of GME-encapsulated nanoparticles was confirmed by TEM, which showed spherical shapes for both types of nanoparticles (Figure 1).…”

Section: Results and Discussion Characterization Of Nanoparticlesmentioning

confidence: 87%

“…Recently, α-mangostin and xanthones were encapsulated in polyvinylpyrrolidone micelles and polyethylene glycolb-poly(N-(2-hydroxypropyl)methacrylamide-dilactate) micelles, respectively, and showed effective antitumor activity. 18,19 Cellulose derivatives, such as ethyl cellulose (EC) and methyl cellulose (MC), are among the most commonly used polymers in the pharmaceutical industry, because they are biocompatible, safe, and inexpensive. 20 For example, EC is a hydrophobic polymer that can encapsulate a number of hydrophobic drugs and natural substances.…”

Section: Introductionmentioning

confidence: 99%

Cellular trafficking and anticancer activity of Garcinia mangostana extract-encapsulated polymeric nanoparticles

Pan-In¹,

Wanichwecharungruang²,

Kim³

2014

IJN

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Garcinia mangostana Linn extract (GME) is a natural product that has received considerable attention in cancer therapy, and has the potential to reduce side effects of chemotherapeutics and improve efficacy. We formulated GME-encapsulated ethyl cellulose (GME-EC) and a polymer blend of ethyl cellulose and methyl cellulose (GME-EC/MC) nanoparticles. We achieved high drug-loading and encapsulation efficiency using a solvent-displacement method with particle sizes around 250 nm. Cellular uptake and accumulation of GME was higher for GME-encapsulated nanoparticles compared to free GME. In vitro cytotoxicity analysis showed effective anticancer activity of GME-EC and GME-EC/MC nanoparticles in HeLa cells in a dose-dependent manner. GME-EC/MC nanoparticles showed approximately twofold-higher anticancer activity compared to GME-EC nanoparticles, likely due to their enhanced bioavailability. GME-encapsulated nanoparticles primarily entered HeLa cells by clathrin-mediated endocytosis and trafficked through the endolysosomal pathway. As far as we know, this is the first report on the cellular uptake and intracellular trafficking mechanism of drug-loaded cellulose-based nanoparticles. In summary, encapsulation of GME using cellulose-derivative nanoparticles – GME-EC and GME-EC/MC nanoparticles – successfully improved the bioavailability of GME in aqueous solution, enhanced cellular uptake, and displayed effective anticancer activity.

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“…At the time this study was being carried out, another study on solid dispersions of ␣-mangostin (Fig. 1) in polyvinylpyrrolidone (PVP) revealed the enhancement of ␣-mangostin solubility and intracellular delivery, although, no enhancement of ␣-mangostin cytotoxic effect was observed with this formulation (Aisha et al, 2012). Herein, this study furnished a formulation of the hit compound with a three-fold improvement in the GI 50 values in MCF-7 cell line.…”

Section: Discussionmentioning

confidence: 83%

Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53–MDM2 interaction

Paiva

Pinto

Teixeira

et al. 2013

International Journal of Pharmaceutics

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a b s t r a c tOne possible approach to overcome solubility complications and enhance the biological activity of drugs is their incorporation into drug delivery systems. Within this scope, several nanosphere and nanocapsule formulations of a new inhibitor of p53-MDM2 interaction (xanthone 1) were developed and their physicochemical properties analyzed. Through the investigation of the effect of several empty nanoparticles on the growth of MCF-7 cells, it was possible to observe that four out of five formulations were cytotoxic and that some correlations between the toxic potential of these polymeric nanoparticles and their properties/composition could be extrapolated. One empty formulation of nanocapsules developed by emulsification/solvent evaporation and containing PLGA, PVA and Mygliol ® 812 was found to be noncytotoxic to this cell line. The corresponding compound 1-loaded nanocapsules showed an incorporation efficiency of 77% and revealed to be more potent than the free drug against cell growth inhibition, which may be related to the enhancement in its intracellular delivery. In an integrative study, the intracellular uptake of nanocapsules was confirmed using fluorescent 6-coumarin and well as compound 1 release from nanocapsules. Overall, it was possible to enhance the effect of the hit inhibitor of p53-MDM2 interaction through the development of suitable noncytotoxic polymeric nanoparticles.

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Solid Dispersions of α-Mangostin Improve Its Aqueous Solubility through Self-Assembly of Nanomicelles

Cited by 90 publications

References 30 publications

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

Cellular trafficking and anticancer activity of Garcinia mangostana extract-encapsulated polymeric nanoparticles

Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53–MDM2 interaction

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