Solid free-form fabrication of drug delivery devices

Wu, Benjamin M.; Borland, Scott W.; Giordano, Russell; Cima, Linda G.; Sachs, Emanuel M.; Cima, Michael J.

doi:10.1016/0168-3659(95)00173-5

Cited by 324 publications

(163 citation statements)

References 12 publications

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“…Additive manufacturing (commonly referred to as 3D printing) of pharmaceuticals with inkjet printing is focused entirely on powder-bed technologies (Wu et al 1996, Ursan et al 2013, Khaled et al 2014. A combination of a powder and a binder 'ink' is used to construct solid macroscopic structures in a layer-by-layer process.…”

Section: D Printing (3dp)mentioning

confidence: 99%

“…A typical powderbed system builds up a structure in a layer-by-layer approach. Early work (Wu et al 1996) showed that standard 3D printing of PCL and PEO, bioresorbable polymers, is feasible to a high resolution by inkjet printing of a binder. However, chloroform and DCM solvents were used in that work and are not appropriate for medical use due to their toxicity and the difficulty of ensuring removal of trace quantities.…”

Section: D Printing (3dp)mentioning

confidence: 99%

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Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

274

185

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Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

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Section: D Printing (3dp)mentioning

confidence: 99%

Section: D Printing (3dp)mentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

274

185

View full text Add to dashboard Cite

show abstract

“…Fabrication of such a device can be achieved through LCC. Wu et al 9 demonstrated this capability with the controlled release from a device fabricated through 3D Printing by selectively depositing droplets of drug int o a p o wder bed of the pill's matrix. As with the previous example, the binder and drug would be delivered in a liquid vehicle, resulting in a less than fully dense part represented by v oids after the liquid evaporates.…”

Section: Representation Visualization and Design Of Fgm Modelsmentioning

confidence: 99%

Modeling and designing functionally graded material components for fabrication with local composition control

et al. 1999

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Solid Freeform Fabrication SFF processes have demonstrated the ability to produce parts with locally controlled composition. In the limit, processes such as 3D Printing can create parts with composition control on a length scale of 100 m. To exploit this potential, new methods to model, exchange, and process parts with local composition control need to be developed. An approach to modeling a part's geometry, topology, and composition is presented. This approach is based on subdividing the solid model into sub-regions and associating analytic composition blending functions with each region. These blending functions de ne the composition throughout the model as mixtures of the primary materials available to the SFF machine. Design tools based u p on distance functions are also introduced, such as the speci cation of composition as a function of the distance from the surface of a part. Finally, the role of design rules restricting maximum and minimum concentrations is discussed.

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“…Common bitmap data lossless compression methods are mainly for ordinary gray scale and color bitmap image data, and they may have low compression ratio, and they are not suitable for the bitmap data compression in the weak light curing 3-D printing system. This paper combines the needs of bitmap data characteristics and the forming process in the light curing three-dimensional rapid printing system, and designs a new bitmap data compression method based on byte which can be used in the light curing three dimensional printing systems [7][8][9]. data.…”

Section: Introductionmentioning

confidence: 99%

Compression Research of Bitmap Data in Three-Dimensional Printing

Xu¹,

Gao²,

Zhang³

2015

TOMEJ

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Abstract:In the paper, it makes 3-D (three dimensional) printing rapid prototyping bitmap data compression research based on bytes has been conducted, in the 3-D printing rapid prototyping system, where the bitmap data format is adopted, and related data storage space is very large. It firstly analyzes the bitmap data characteristics in 3-D printing rapid prototyping system and the commonly methods used in nondestructive bitmap compression, and it designs the bitmap data compression coding method based on bytes. The compression method has the characteristics such as high compression ratio, fast speed of compression and decompression, less time consuming, etc. Therefore, it can meet the increasing demand of data compression in the 3-D printing rapid prototyping system.

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Solid free-form fabrication of drug delivery devices

Cited by 324 publications

References 12 publications

Inkjet printing for pharmaceutics – A review of research and manufacturing

Inkjet printing for pharmaceutics – A review of research and manufacturing

Modeling and designing functionally graded material components for fabrication with local composition control

Compression Research of Bitmap Data in Three-Dimensional Printing

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