Solid lipid nanoparticles, an effective carrier for classical antifungal drugs

Almawash, Saud

doi:10.1016/j.jsps.2023.05.011

Cited by 14 publications

(6 citation statements)

References 102 publications

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“…The aqueous phase of SLNs is distributed with solid lipids such as triglycerides, fatty acids, partial glycerides, waxes, and steroids ranging from 0.1 to 30% (w/w), which are stabilized by surfactants such as phospholipids, poloxamers, sorbitan esters, etc. that are typically used in the concentration range of 0.5-5% (w/w) [66]. The typical SLN size is between 50 and 1000 nm [65].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Emergence of Advanced Antifungal-Delivery Approaches for the Treatment of Tinea Pedis

Abdalla,

El-Sawy,

Ramadan

2024

ERU Research Journal

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A common fungal infection of the feet known as tinea pedis, which is also known as athlete's foot, significantly lowers quality of life. Its occurrence is caused by dermatophytes, a form of fungus that grows on the dead skin of the feet. Itching, scaling, redness, and skin breaking are among the symptoms that can be brought on by tinea pedis. In extreme circumstances, it may also result in nail infections and painful blisters. Antifungal medications, either systemic or topical, are widely used to treat tinea pedis. In recent years, there has been a surge in interest in developing novel medication delivery systems/strategies for the treatment of tinea pedis. By improving the drug's penetration into the skin and lowering the chance of systemic side effects, these systems seek to increase the safety and efficacy of antifungal therapy. This review has covered the many effective ways to treat tinea pedis, including traditional and state-of-the-art sophisticated delivery techniques. Furthermore, prospective avenues for treatment optimization and recurrence prevention of these severe fungal infections have been emphasized.

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Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Emergence of Advanced Antifungal-Delivery Approaches for the Treatment of Tinea Pedis

Abdalla,

El-Sawy,

Ramadan

2024

ERU Research Journal

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“…However, the main objective of these reviews is to introduce different types of nanoparticles, and they do not provide an in-depth summary of the various polymer types used in antifungal nanosystems. While some researchers have provided overviews of nanosystems based on chitosan [ 36 , 37 ], liposomes [ 38 , 39 ], and magnetic [ 40 ] nanoparticles for antifungal drug delivery, there is currently no comprehensive review or detailed introduction specifically dedicated to the different polymer types used in constructing antifungal nanosystems.…”

Section: Introductionmentioning

confidence: 99%

Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

et al. 2023

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Nanosystems-based antifungal agents have emerged as an effective strategy to address issues related to drug resistance, drug release, and toxicity. Among the diverse materials employed for antifungal drug delivery, polymers, including polysaccharides, proteins, and polyesters, have gained significant attention due to their versatility. Considering the complex nature of fungal infections and their varying sites, it is crucial for researchers to carefully select appropriate polymers based on specific scenarios when designing antifungal agent delivery nanosystems. This review provides an overview of the various types of nanoparticles used in antifungal drug delivery systems, with a particular emphasis on the types of polymers used. The review focuses on the application of drug delivery systems and the release behavior of these systems. Furthermore, the review summarizes the critical physical properties and relevant information utilized in antifungal polymer nanomedicine delivery systems and briefly discusses the application prospects of these systems.

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“…The actual localization of the payload depends on the active molecule's nature. As solid lipid nanoparticles are able to encapsulate both hydrophobic and water-soluble compounds [21,22], three different models are proposed: a homogeneous distribution of drugs, a drug-enriched shell (for hydrophilic molecules), and a drug-enriched core for lipophilic compounds [23]. The transition of the crystalline lipidic phase to a lower energy state that consists of a more packed and ordered crystal lattice causes the release of active compounds from solid lipid nanoparticles [24,25], as well as precipitation and agglomeration of the nanoparticulate matter and the consequent progressive destruction of the system.…”

Section: Introduction Experimental Design Approaches On Lipid Nanocar...mentioning

confidence: 99%

Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide

Talarico,

Pepi,

Susino

et al. 2023

Molecules

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Principles of quality by design and design of experiments are acquiring more importance in the discovery and application of new drug carriers, such as solid lipid nanoparticles. In this work, an optimized synthesis of solid lipid nanoparticles loaded with Triamcinolone Acetonide is presented using an approach that involves Stearic Acid as a lipid, soy PC as an ionic surfactant, and Tween 80 as a nonionic surfactant. The constructed circumscribed Central Composite Design considers the lipid and nonionic surfactant quantities and the sonication amplitude in order to optimize particle size and Zeta potential, both measured by means of Dynamic Light Scattering, while the separation of unentrapped drug from the optimized Triamcinolone Acetonide-loaded solid lipid nanoparticles formulation is performed by Size Exclusion Chromatography and, subsequently, the encapsulation efficiency is determined by HPLC-DAD. The proposed optimized formulation—with the goal of maximizing Zeta potential and minimizing particle size—has shown good accordance with predicted values of Zeta potential and dimensions, as well as a high value of encapsulated Triamcinolone Acetonide. Experimental values obtained from the optimized synthesis reports a dimension of 683 ± 5 nm, which differs by 3% from the predicted value, and a Zeta potential of −38.0 ± 7.6 mV (12% difference from the predicted value).

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Solid lipid nanoparticles, an effective carrier for classical antifungal drugs

Cited by 14 publications

References 102 publications

Emergence of Advanced Antifungal-Delivery Approaches for the Treatment of Tinea Pedis

Emergence of Advanced Antifungal-Delivery Approaches for the Treatment of Tinea Pedis

Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

Design and Optimization of Solid Lipid Nanoparticles Loaded with Triamcinolone Acetonide

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