Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery

Nasirizadeh, Samira; Malaekeh‐Nikouei, Bizhan

doi:10.1016/j.jddst.2019.101458

Cited by 88 publications

(36 citation statements)

References 97 publications

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“…SLNs NPs having a solid lipid core, because they are composed of lipids, which are in the solid state at room temperature. [27][28][29] Their surface is stabilized by nonionic or ionic surfactants. Although the solid core renders SLNs relatively stable, the fabrication of dye-loaded SLNs is challenging, because the solidified lipid can form orientated crystalline domains that gradually expel encapsulated materials to the particle surface.…”

Section: Introductionmentioning

confidence: 99%

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Klymchenko

Liu

Collot

et al. 2020

Adv Healthcare Materials

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Lipid nanoemulsions (NEs), owing to their controllable size (20 to 500 nm), stability and biocompatibility, are now frequently used in various fields, such as food, cosmetics, pharmaceuticals, drug delivery, and even as nanoreactors for chemical synthesis. Moreover, being composed of components generally recognized as safe (GRAS), they can be considered as “green” nanoparticles that mimic closely lipoproteins and intracellular lipid droplets. Therefore, they attracted attention as carriers of drugs and fluorescent dyes for both bioimaging and studying the fate of nanoemulsions in cells and small animals. In this review, the composition of dye‐loaded NEs, methods for their preparation, and emerging biological applications are described. The design of bright fluorescent NEs with high dye loading and minimal aggregation‐caused quenching (ACQ) is focused on. Common issues including dye leakage and NEs stability are discussed, highlighting advanced techniques for their characterization, such as Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS). Attempts to functionalize NEs surface are also discussed. Thereafter, biological applications for bioimaging and single‐particle tracking in cells and small animals as well as biomedical applications for photodynamic therapy are described. Finally, challenges and future perspectives of fluorescent NEs are discussed.

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Section: Introductionmentioning

confidence: 99%

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Klymchenko

Liu

Collot

et al. 2020

Adv Healthcare Materials

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show abstract

“…These particles are therefore considered an effective carrier for a wide spectrum of drugs, with sufficient protection, sustainable drug release, and improved bioavailability. [27,33] Biocompatible and biodegradable ingredients, high cell uptake, good protection of drugs in acidic pH, long shelf life, ease of drug entrapment [32] Gelling tendency [29] Nanostructured lipid carriers (NLCs)…”

Section: Overview Of Lipid-based Nanoparticlesmentioning

confidence: 99%

“…Solid and liquid lipids (fats and oils), surfactants [32] All SLN's advantages but higher drug encapsulation, more sustainable drug release, better diuretic activity and fewer drug lost within storage time [32] Optimization required of the ratio of solid/liquid lipids The drawbacks related to their limited stability, toxicity, low loading capacity, and convoluted manufacturing has sparked the interest of researchers to develop a new class of particles became [25,29], mainly aiming at improving the encapsulation efficiency [12]. Solid lipid nanoparticles (SLNs, Figure 2) are made of solid fats and surfactants to form a spherical nanoparticle with a solid lipid core and a monolayer shell [33,34].…”

Section: Overview Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

et al. 2021

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COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology. Lipid-based nanoparticles have played a pivotal role in the successes of COVID-19 vaccines and many other nanomedicines, such as Doxil® and Onpattro®, and have therefore been considered as the frontrunner in nanoscale drug delivery systems. In this review, we aim to highlight the progress in the development of these lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines. The lipid-based nanoparticles discussed in this review are liposomes, niosomes, transfersomes, solid lipid nanoparticles, and nanostructured lipid carriers. We particularly focus on the innovations that have obtained regulatory approval or that are in clinical trials. We also discuss the physicochemical properties required for specific applications, highlight the differences in requirements for the delivery of different cargos, and introduce current challenges that need further development. This review serves as a useful guideline for designing new lipid nanoparticles for both preventative and therapeutic vaccines including immunotherapies.

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“…Solid lipid nanoparticles (SLNs) can be defined as colloidal dispersions composed of lipids that are solid at room and body temperature ( Figure 3 ). SLNs were developed as alternative carriers to liposomes and polymeric nanoparticles in order to overcome the disadvantages, such as polymer degradation, cytotoxicity, large-scale manufacturing problems, drug leakage, and instability [ 86 , 87 ]. The solid lipid core of SLNs forms a matrix that can encapsulate both hydrophobic and lipophilic drugs.…”

Section: Nddss In the Delivery Of Nrf2 Modulators For Cancer Therapymentioning

confidence: 99%

Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy

et al. 2021

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The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery of new therapeutic agents and potential drug delivery systems. In particular, the introduction of nano-sized drug delivery systems (NDDSs) has opened new horizons for effective cancer treatment. These are considered potential systems that provide deep tissue penetration and specific drug targeting. On the other hand, nuclear factor erythroid 2-related factor 2 (NRF2)-based anticancer treatment approaches have attracted tremendous attention and produced encouraging results. However, the lack of effective formulation strategies is one of the factors that hinder the clinical application of NRF2 modulators. In this review, we initially focus on the critical role of NRF2 in cancer cells and NRF2-based anticancer treatment. Subsequently, we review the preparation and characterization of NDDSs encapsulating NRF2 modulators and discuss their potential for cancer therapy.

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Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery

Cited by 88 publications

References 97 publications

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Dye‐Loaded Nanoemulsions: Biomimetic Fluorescent Nanocarriers for Bioimaging and Nanomedicine

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy

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