Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis

Sonawane, Ravindra S.; Harde, Harshad; Katariya, Mahesh; Agrawal, Satyam Kumar; Jain, Sanyog

doi:10.1517/17425247.2014.938634

Cited by 100 publications

(40 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conclusion, sustained release of CPT appears to be beneficial in the treatment of psoriasis as it leads to its adequate absorption, which helps to reduce drug toxicity [20]. In similar studies, Kaur [4] prepared a clobitasol propionate and CPT nanoemulsion that completely released CPT at 10 h. Also, the cumulative release of CPT from betamethasone dipropionate and CPT loaded solid lipid nanoparticles (CT-BD-SLNs) was only 31.0% at 48 h [21].…”

Section: Discussionmentioning

confidence: 89%

“…In order to further study the permeability and pharmacokinetics of CPT in isolated skin, a thicker, less permeable pig ear skin was used in this study, instead of thickened psoriasis skin. The formation of scaly plaques in the psoriasis area and the thickening of the stratum corneum cause the epidermis to become rough and become a major obstacle to the transdermal absorption of topical drugs [21]. The ability of free CPT to pass through psoriasis skin is primarily affected by the difference in drug concentration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Song

Cheng

et al. 2019

IJMS

View full text Add to dashboard Cite

An exopolysaccharides/calcipotriol (EPS/CPT) emulsion was prepared using bacterial EPS as emulsifier, sunflower oil as an oil phase and CPT as the loaded drug, and the effect of this emulsion on psoriasis vulgaris treatment was evaluated. An EPS composed of mannose (70.56%) and glucose (29.44%) was obtained from the marine mangrove bacteria Bacillus amyloliquefaciens ZWJ (Zhu Wenjing) strain. The EPS has significant emulsifying activity at the concentration of 1.5%. The prepared EPS/CPT emulsion has small and stable particle size, with a drug content of 0.00492%, and good spreading properties. The in vitro drug release results revealed that the emulsion showed a certain sustained release effect. In vitro and in vivo animal experiments show that the EPS/CPT emulsion can effectively treat psoriasis vulgaris by increasing the accumulation of CPT in psoriatic skin lesions and reducing the levels of inflammatory cells and inflammatory factors (TNF and IL6). Additionally, it has a certain effect on reducing the side effects associated with CPT. This study lays a foundation for the research of EPS in the topical application of medical materials and treatment of psoriasis.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Song

Cheng

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Although combination therapy has shown promising outcomes yet, unifying the pharmacokinetics of individual drugs, on-target accumulation, and intracellular uptake of various drug molecules are the major concerns which need to be addressed to get the control over dosage for maximal therapeutic effect. To circumvent these problems, variety of formulation approaches has been reported for the co-administration of drug molecules (Jain et al, 2014a;Sonawane et al, 2014;Swarnakar et al, 2014;Tan et al, 2017a;Tan et al, 2017b;Yao et al, 2014). Co-encapsulation of gambogic acid and sulforaphane in combination with DTX in PLGA based nanoparticles were reported which demonstrated significantly higher pharmacodynamic efficacy as compared to free drug combination (Huang et al, 2016;.…”

Section: Introductionmentioning

confidence: 99%

Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate

Kushwah

Katiyar

Agrawal

et al. 2018

International Journal of Pharmaceutics

Self Cite

View full text Add to dashboard Cite

The present study investigates effect of linkers [zero length (without linker), short length linker (glycine and lysine) and long length linker (PEG1000, PEG2000 and PEG3500)] on pharmacokinetics and toxicity of docetaxel (DTX) and gemcitabine (GEM) bio-conjugates. Conjugates were synthesized via carbodiimide chemistry and characterized by H NMR and FTIR. Conjugation of DTX and GEM via linkers showed diverse physiochemical and plasma stability profile. Cellular uptake mechanism in MCF-7 and MDA-MB-231 cell lines revealed clathrin mediated internalization of bio-conjugates developed by using long length linkers, leading to higher cytotoxicity compared with free drug congeners. DTX-PEG3500-GEM and DTX-PEG2000-GEM demonstrated 4.21 and 3.81-fold higher AUC of GEM in comparison with GEM alone. DTX-PEG2000-GEM and DTX-PEG3500-GEM exhibited reduced hepato-, nephro- and haemolytic toxicity as evident via histopathology, biochemical markers and SEM analysis of RBCs. Conclusively, PEG2000 and PEG3500 significantly improved pharmacokinetics without any sign of toxicity and hence can be explored further for the development of dual-drug conjugates for better therapeutic efficacy.

show abstract

“…They conducted in vitro and in vivo studies in which in vitro (HaCaT cell line) study demonstrated that SLNs delayed the abrupt growth of keratinocytes, while in vivo mouse tail model showed that SLNs gel significantly decreased the epidermal thickness and increased melanocyte count in comparison to commercial ointment. [58] Findings of the studies suggest that there is significant improvement in therapeutic index in the treatment of psoriasis by SLN gel base developed in this investigation over plain drug gel currently available in the market.…”

Section: The Key Advantages Of Sln Are As Followsmentioning

confidence: 80%

Untitled

Aggarwal¹

2018

AJP

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory disease influencing 1-3% of the all-inclusive community with significant hindrance to personal quality of life. These conditions may adversely influence the patient's quality of life and prompt psychosocial stretch. Psoriasis can be arranged as mild, moderate, and severe conditions. Mild psoriasis prompts the formation of rashes, and when it ends up moderate, the skin transforms into scaly. It is important to control and limit the indications of psoriasis to give patient long-lasting protection since psoriasis is not presently curable yet it can go into reduction, creating a normal/ordinary skin surface. Customary conventional treatments for psoriasis are utilized for the treatment of incorporate topical, oral, or systemic formulation yet have a potential for long-term danger and may not generally give adequate change of the illness. Dermal treatment guaranteeing percutaneous penetration is presently very suggested in topical signs for psoriatic patients, which can be accomplished utilizing pharmaceutical nanotransporters nanovesicle and nanoparticle and so forth. The advancement of novel treatments focusing on the pathogenesis of psoriasis presently gives new and efficient treatment alternatives such as nanoparticulate/nanovesicular gels, which are more powerful in diminishment of purities, scaling, and hyperkeratosis of psoriasis plaque. Because of high drug loading, productivity, and stability, novel transporter diminishes the scaly patches and decreases of humoral immunity. Point of the survey is to center around the effect of nanotechnology construct drug delivery approaches in light of different anti-psoriasis drugs delivery for the fruitful treatment of psoriasis with negligible poisonous or toxic response.

show abstract

Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis

Abstract: The developed SLNs gel is expected to be potential strategies for treatment of psoriasis and other topical diseases.

Cited by 100 publications

References 48 publications

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Preparation of Calcipotriol Emulsion Using Bacterial Exopolysaccharides as Emulsifier for Percutaneous Treatment of Psoriasis Vulgaris

Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate

Untitled

Contact Info

Product

Resources

About