Solid lipid nanoparticles Production, characterization and applications

Mehnert, W.; Mäder, Karsten

doi:10.1016/s0169-409x(01)00105-3

Cited by 2,615 publications

(1,890 citation statements)

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“…SLNs introduced in 1991 [22], have emerged as an alternative colloidal carriers due to advantages such as improved physical stability, good tolerability, efficient incorporation of lipophilic drugs in the lipid core of the SLNs and ease of scale up and manufacturing [23].…”

Section: Introductionmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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(2016) The design of naproxen solid lipid nanoparticles to target skin layers. Colloids and Surfaces B: Biointerfaces, This version is available from Sussex Research Online: http://sro.sussex.ac.uk/67745/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical Abstract Highlights  Naproxen solid lipid nanoparticles (Nap-SLN) can successfully be prepared by ultrasonication  Properties of these nanoparticles can be optimized by lipid concentrations  HLB of the surfactants played a crucial effect on properties of solid lipid nanoparticles  Nap-SLN increased the drug concentration in skin layer rather than systemic absorption Accepted Manuscript AbstractThe aim of the current investigation was to produce naproxen solid lipid nanoparticles (Nap-SLNs) by the ultrasonication method to improve its skin permeation and also to investigate the influence of Hydrophilic-lipophilic balance (HLB) changes on nanoparticles properties. The properties of obtained SLNs loaded with naproxen were characterized by photon correlation spectroscopy (PCS), transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). FT-IR was also used to investigate any interaction between naproxen and the excipients used at the molecular level during the preparation of the SLNs. The performance of the formulations was investigated in terms of skin permeation and also the retention of the drug by the skin. It was found that generally, with increasing the lipid concentration, the average particle size and polydispersity index (PDI) ...

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Section: Introductionmentioning

confidence: 99%

The design of naproxen solid lipid nanoparticles to target skin layers

Âkbari

Saeedi

Morteza‐Semnani

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…The later consist of a solid lipid matrix with a high content of liquid lipid (Radke, 2003). Both SLN and NLC possess a number of features advantageous for the topical route of application (Müller et al, 1995(Müller et al, , 2000d(Müller et al, , 2002Mehnert and Mäder, 2001). These carriers are composed of physiological and biodegradable lipids of low systemic toxicity and also low cytotoxicity (Müller et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

Souto

Wissing

Barbosa

et al. 2004

International Journal of Pharmaceutics

588

206

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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40 • C. For all tested formulations the entrapment efficiency was higher than 50%.The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.

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“…1,2 The versatility of nanosystems allows tuneable surface modification and loading with different chemicals (drugs, imaging agents, targeting vectors) with the aim of fine-optimizing the biological properties of the nanocarriers, while simultaneously enabling them to perform diagnostically and/or therapeutically important functions. 3,4 Lipid-containing nanoparticles (LNPs), 5 like micelles, liposomes, and solid lipid nanoparticles, or other similar nanosystems (such as the recently developed dendrimersomes) [6][7][8] are based on supramolecular aggregates obtained by spontaneous assembling in aqueous solution of phospholipids alone or in mixture with other amphiphilic molecules. Such objects have been frequently used as nanocarriers for drug delivery and imaging applications due to their great chemical versatility that allows the loading of hydrophobic, amphiphilic, and hydrophilic substances, and surface decoration with targeting vectors, blood lifetime modulators, and diagnostic agents.…”

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confidence: 99%