Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

Souto, Eliana B.; Wissing, S. A.; Barbosa, C. M. B. M.; Müller, Rainer H.

doi:10.1016/j.ijpharm.2004.02.032

Cited by 589 publications

(234 citation statements)

References 12 publications

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“…The size of both systems remained stable during 90 days of storage. 22 Interestingly, the same research group published converse results, reporting that NLC was unstable over 90 days at room temperature and even at 4°C, while drug-loaded SLN was stable under both conditions. This might be attributed to the effect of the solid and liquid lipid types which were different from those in a previous study in which Compritol® 888 ATO and α-tocopherol were administered in preparing NLC instead of Dynasan® 116 and Miglyol® 812, respectively.…”

Section: Introductionmentioning

confidence: 94%

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The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

180

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Section: Introductionmentioning

confidence: 94%

“…21 They are prepared from one or blends of two or more solid lipids. 22 SLNs merge the superiorities of emulsions, liposomes, and polymeric nanoparticles. The solid matrix can preserve encapsulated drugs against chemical instability and provide controlled drug release patterns (compared to nanoemulsions).…”

Section: Introductionmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

180

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“…It is known that the structure of SLNs protects labile drugs from degradation or oxidation by encapsulation (8)(9)(10)(11)17). TEAC experiments showed that the encapsulation in SLNs was successful in protecting Q10 from oxidation.…”

Section: Resultsmentioning

confidence: 99%

“…SLNs have many advantages, especially for dermal applications such as occlusion, modulation of drug release and penetration into the skin (9). Since they are made from solid lipids, chemically unstable lipid soluble compounds that are sensitive to oxidation can be successfully encapsulated in the SLNs (8,10).…”

mentioning

confidence: 99%

Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

Korkm¹,

Gökçe²,

Özer³

2013

Acta Pharmaceutica

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Skin is the protective organ of the body with an area around 2 m 2 . The hazardous potential of toxins, pathogens and UV radiation are avoided by the protection that skin supplies (1). UV radiation is the main source of energy that initiates reactive oxygen species (ROS). Formation of ROS leads to oxidative damage in DNA, proteins and lipids. The skin has an enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic (antioxidant) protection mechanism against these damages; however, excess ROS production overcomes this protection and causes several diseases such as cancer (2, 3). Hence, effective delivery of an antioxidant into skin in required levels is an important challenge. There are two main steps limiting the effective delivery antioxidants, oxidation of the active substance and carrying the active substance to the viable epidermis.Antioxidants are defined as substances that, when present in a low concentration compared to that of oxidizable substrates, significantly delay or inhibit oxidation of that substance (4). In general, antioxidants act by the chain breaking reaction, by reducing the concentration of reactive oxygen species, by scavenging initiating radicals and by chelating transition metal catalysts (5). Coenzyme Q10 (Q10) is the only lipid soluble endogenous antioxidant. It supports ATP generation during aerobic cellular respiration in the electron transport chain in the mitochondria and inhibits cell membrane peroxidation in reduced form (6, 7). However, it is very difficult to prepare a formulation that helps Q10 delivery to deeper layers of the skin due to the low aqueous solubility of Q10 (log P >10) and due to the barrier function of stratum corneum (8).In the second half of the nineties there was an increasing interest in investigating solid lipid nanoparticles (SLNs) for dermal application. SLNs have many advantages, especially for dermal applications such as occlusion, modulation of drug release and penetration into the skin (9). Since they are made from solid lipids, chemically unstable lipid soluble compounds that are sensitive to oxidation can be successfully encapsulated in the SLNs (8, 10). Several molecules were incorporated into lipid nanoparticles, e.g., ascorbyl palmitate, resveratrol, retinol and retinyl palmitate, vitamin E and vitamin E acetate (8,(11)(12)(13)(14). It has been shown that systemic uptake of active substances (e.g., isotretinoin) through skins could be avoided and SLN could increase the accumulative uptake of the active material in the skin (15). SLNs are produced as liquid dispersions and their incorporation into hydrogels or emulsions helps enhance the retention time in the applied area and patient compliance (16,17).Hydrogels are generally formed from carbomers that have the ability to absorb water, get hydrated and swell by neutralization with a base. Carbomers have been mainly used in liquid or semi-solid pharmaceutical formulations in order to modify their flow characteristics (17,18).The aim of this work was to carry an effic...

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“…27,28 SLNs give stable nanosuspension for an extended period of time in comparison with liposomes. 29,30 Furthermore, the SLNs are made of physiologically well-tolerated and generally recognized as safe (GRAS) excipients which reduce the cytotoxicity, leading to their wide variety of applications including dermal, oral, pulmonary, and intravenous use compared with polymeric nanoparticles. 26,31 The greatest benefit of SLNs is the possibility of their industrial scale production.…”

Section: -Azacytidine Was First Synthesized In 1963mentioning

confidence: 99%

Enhanced in Vitro Anti-Tumor Activity of 5-Azacytidine by Entrapment into Solid Lipid Nanoparticles

Jahanfar¹,

Hasani²,

Shanebandi³

et al. 2016

Adv Pharm Bull

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Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

Cited by 589 publications

References 12 publications

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

Enhanced in Vitro Anti-Tumor Activity of 5-Azacytidine by Entrapment into Solid Lipid Nanoparticles

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