Solid-phase extraction of nonsteroidal anti-inflammatory drugs in urine and water samples using acidic calix[4]arene intercalated in LDH followed by quantification via HPLC-UV

Shafiei-Navid, Saied; Hosseinzadeh, Rahman; Ghani, Milad

doi:10.1016/j.microc.2022.107985

Cited by 10 publications

(2 citation statements)

References 73 publications

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“…Finally, the developed method was compared with other methods reported for the extraction of NSAIDs from aqueous samples in terms of the extraction technique, extraction time, sample volume, instrument used for analysis, LOQ, and RSD (Table S4). Many of these methods rely on solid-phase extraction (SPE) [14], molecularly imprinted solidphase extraction (MISPE) [15,16], and magnetic solid-phase extraction (MSPE) [17,18]. However, these techniques require a large sample volume and a long time for analyte extraction (10-160 min) and desorption.…”

Section: Analytical Performance and Recovery From Tap Water Samplesmentioning

confidence: 99%

A Cyanoalkyl Silicone GC Stationary-Phase Polymer as an Extractant for Dispersive Liquid–Liquid Microextraction

Abdelaziz,

Danielson

2024

Separations

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In this work, three cyanoalkyl silicone GC stationary-phase polymers, namely OV-105, OV-225, and OV-275, were investigated as potential extractants for dispersive liquid–liquid microextraction (DLLME). The OV-225 polymer (cyanopropylmethyl-phenylmethylsilicone) exhibited the cleanest chromatographic background and was extensively studied. The proposed polymer was tested through the DLLME of four non-steroidal anti-inflammatory drugs from aqueous samples, followed by HPLC separation with UV detection at 230 nm. To achieve the maximum enrichment, the experimental conditions that influence the DLLME process were optimized using one-factor-at-a-time and design-of-experiment (DoE) approaches. The extraction variables (polymer mass, dispersive solvent volume, buffer pH, and mixing time) were screened by implementing a two-level full factorial design (FFD). Significant variables were fine-tuned using response surface methodology based on a face-centered central composite design (CCD). The optimum conditions were 10 mg of polymer (extraction medium); 50 µL of tetrahydrofuran (dispersive solvent); 100 µL of phosphate buffer pH 2.75 ([PO43−] = 100 mM); and 3 min of vortex mixing. The addition of salt had a minimal effect on the enrichment factors. In the optimum conditions, enrichment factors up to 46 were achieved using 1.5 mL samples. Calibration curves exhibited correlation coefficients > 0.999 using 4-pentylbenzoic acid as an internal standard. The limits of quantitation were 5 ng/mL for naproxen, 10 ng/mL for diflunisal, 25 ng/mL for indomethacin, and 75 ng/mL for ibuprofen. The analysis of spiked tap water samples showed adequate relative recoveries and precision. In conclusion, the proposed polymer (OV-225) is a potential greener alternative to traditional organic extractants used in DLLME.

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Section: Analytical Performance and Recovery From Tap Water Samplesmentioning

confidence: 99%

A Cyanoalkyl Silicone GC Stationary-Phase Polymer as an Extractant for Dispersive Liquid–Liquid Microextraction

Abdelaziz,

Danielson

2024

Separations

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“…Prior to instrumental analysis, pretreatment is necessary, which involves selecting a suitable method for extracting specific NSAIDs from complex biological matrices. Classical sample preparation techniques such as liquid-liquid extraction (LLE) [ 24 , 25 ], solid phase extraction (SPE) [ 26 , 27 ], solid phase microextraction (SPME) [ 28 ], dispersive solid phase extraction (d-SPE) [ 29 , 30 ], and QuEChERS have been successfully used for the extraction of NSAIDs from biological matrices [ 31 ]. It is critical to appropriately prepare samples for analytical methods to ensure suitable selectivity and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of NSAIDs in Rat Plasma Using 3D-Printed Sorbents by LC-MS/MS: An Approach to Pre-Clinical Pharmacokinetic Studies

et al. 2023

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Analytical sample preparation techniques are essential for assessing chemicals in various biological matrices. The development of extraction techniques is a modern trend in the bioanalytical sciences. We fabricated customized filaments using hot-melt extrusion techniques followed by fused filament fabrication-mediated 3D printing technology to rapidly prototype sorbents that extract non-steroidal anti-inflammatory drugs from rat plasma for determining pharmacokinetic profiles. The filament was prototyped as a 3D-printed sorbent for extracting small molecules using AffinisolTM, polyvinyl alcohol, and triethyl citrate. The optimized extraction procedure and parameters influencing the sorbent extraction were systematically investigated by the validated LC-MS/MS method. Furthermore, a bioanalytical method was successfully implemented after oral administration to determine the pharmacokinetic profiles of indomethacin and acetaminophen in rat plasma. The Cmax was found to be 0.33 ± 0.04 µg/mL and 27.27 ± 9.9 µg/mL for indomethacin and acetaminophen, respectively, at the maximum time (Tmax) (h) of 0.5–1 h. The mean area under the curve (AUC0–t) for indomethacin was 0.93 ± 0.17 µg h/mL, and for acetaminophen was 32.33± 10.8 µg h/mL. Owing to their newly customizable size and shape, 3D-printed sorbents have opened new opportunities for extracting small molecules from biological matrices in preclinical studies.

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Fast and efficient extraction and determination of nonsteroidal anti‐inflammatory drugs using poly(8‐hydroxyquinoline)‐coated magnetic graphene oxide nanocomposite prior to capillary electrophoresis analysis in wastewater, breast milk, and urine samples

Shahsavani,

Fakhari

2024

Electrophoresis

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In this study, magnetic graphene oxide coated with poly(8‐hydroxyquinoline) was successfully synthesized, characterized, and utilized as a novel sorbent for the ultrasonic‐assisted dispersive magnetic solid‐phase extraction of naproxen and ibuprofen. These analytes served as representative analytes for two nonsteroidal anti‐inflammatory drugs in various real samples. Characterization techniques, such as IR, X‐ray powder diffraction, field emission scanning electron microscopy, energy‐dispersive X‐ray‐mapping, and Brunauer‐Emmett‐Teller (BET), were used to confirm the correctness synthesis and preparation of the nanocomposites. Effective parameters on the extraction efficiency were investigated to maximize the analytical performance of the developed method. The dynamic range (1–1000 µg L−1), coefficients of determination (R2 ≥ 0.997), the limits of detection (0.3–1.0 µg L−1), and limit of quantification (1.0–3.0 µg L−1), intra‐day and inter‐day precisions (3.5%–7.2%) were achieved. The method validation results showed extraction recovery ranging from 80.4% to 96.0% and preconcentration factors ranging from 137 to 140.

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Solid-phase extraction of nonsteroidal anti-inflammatory drugs in urine and water samples using acidic calix[4]arene intercalated in LDH followed by quantification via HPLC-UV

Cited by 10 publications

References 73 publications

A Cyanoalkyl Silicone GC Stationary-Phase Polymer as an Extractant for Dispersive Liquid–Liquid Microextraction

A Cyanoalkyl Silicone GC Stationary-Phase Polymer as an Extractant for Dispersive Liquid–Liquid Microextraction

Analysis of NSAIDs in Rat Plasma Using 3D-Printed Sorbents by LC-MS/MS: An Approach to Pre-Clinical Pharmacokinetic Studies

Fast and efficient extraction and determination of nonsteroidal anti‐inflammatory drugs using poly(8‐hydroxyquinoline)‐coated magnetic graphene oxide nanocomposite prior to capillary electrophoresis analysis in wastewater, breast milk, and urine samples

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