Solid-phase extraction of the alcohol abuse biomarker phosphatidylethanol using newly synthesized polymeric sorbent materials containing quaternary heterocyclic groups

Duarte, Mariana; Jagadeesan, Kishore; Billing, Johan; Yilmaz, Ecevit; Laurell, Thomas; Ekström, Simon

doi:10.1016/j.chroma.2017.08.051

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…In order to avoid the loss of target analyte during analysis, a suitable sample extraction method should be used for the quantification of biomarkers. 90,93,94 Serum and plasma are among the most widely used matrices as they contain the elements of all the proteins produced in the body. 95 Nevertheless, some proteins like serum immunoglobulin and albumin are so dominant and lead to mask the other low abundant proteins.…”

Section: •3 Solid-phase Extractionmentioning

confidence: 99%

“…A newly synthesized polymeric sorbent material containing quaternary heterocyclic groups (quaternized 1-vinyl imidazole) with a backbone poly-trimethylolpropane trimethacrylate was found more appropriate for extraction of PEth in spiked blood reflecting the maximum analyte recovery. 104 Some other publications have extensively reviewed the strategies used for serum/plasma fractionation in biomarker discovery in various diseases. [105][106][107] Bioanalysis of different drugs reported using SPE as the sample preparation technique has been summarized in Table 3.…”

Section: •3 Solid-phase Extractionmentioning

confidence: 99%

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Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Sharma

Dhakne

et al. 2019

ANAL. SCI.

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Sample preparation is a highly important and integral part of bioanalysis for cleaning up the complex biological matrices and thereby minimizing matrix effect. Matrix effect can jeopardize the precise quantification and adversely affect the reliability of liquid chromatography-mass spectrometry-based analytical results by alteration of analyte ionization. Matrix components result in suppression or enhancement of the intensity of analyte response. In spite of the high specificity and selectivity of tandem mass spectrometry, a relatively higher concentration of coeluted matrix elements present in biofluids may alter the efficiency of quantification of a bioanalytical method. Numerous literature reports different types of sample preparation techniques employed in bioanalysis. In this review, the strategies for selection of the appropriate sample clean-up technique in bioanalysis are discussed extensively. A paradigm shift in the arena of sample preparation and bioanalytical approaches involving the liquid chromatography-mass spectroscopic technique has been scrutinized. Current trends and possible future advancements in the field of biological sample extraction methods, including instrumental techniques are analyzed in detail.

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Section: •3 Solid-phase Extractionmentioning

confidence: 99%

Section: •3 Solid-phase Extractionmentioning

confidence: 99%

Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Sharma

Dhakne

et al. 2019

ANAL. SCI.

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“…Coupling of different biopolymers has been achieved physically or chemically by crosslinking [46][47][48][49][50][51]. Several functional groups have been grafted for this purpose, such as amidoxime groups [52], dithiooxamide [22], quaternary ammonium derivatives [53], sulfonic moieties [54], amino acid derivatives [55,56], amine and thion [57], amino sulfonic acid [58], phosphorus groups [59,60] heterocyclic groups [61][62][63], and the green synthesized materials [64].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Sulfur-Grafted Chitosan Biopolymers and Improvement to Their Sorption of Silver Ions from Different Aqueous Solutions

Hamza,

El-Habibi,

Abdel-Rahman

et al. 2024

Sustainability

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A functionalized chitosan thiourea composite (CH-TU) was successfully synthesized using formaldehyde as a crosslinking agent for enhancing silver recovery from different aqueous solutions. Comparison sorption studies with a non-functionalized composite (CH-F) as a reference material were conducted. Grafting led to an improvement in the sorption performances, i.e., 0.763 mmol Ag g−1 for CH-F vs. 2.125 mmol Ag g−1 for CH-TU. The pseudo-first-order rate equation (PFORE) was fitted to the sorption kinetics at saturation times of 40 and 30 min for CH-F and CH-TU, respectively, while the sorption isotherms were fitted with Langmuir and Sips equations for both sorbents. Fourier transform infrared (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), nitrogen sorption–desorption isotherms (BET-surface area), elemental analysis, thermogravimetric analysis (TGA) and pH of the zero charge (pHpzc) were used to characterize and investigate the sorption mechanism. Sorption was performed three times to check the reproducibility, while the sorption performances were stable over 20 cycles, with a limited decrease in performance (5 and 3% for CH-F and CH-TU, respectively). Nitric acid solution (0.3 M) was efficient for desorbing the adsorbed metal ions. The grafted sorbent with thiourea is considered as a promising tool for recovering Ag(I) from acidic waste leachate derived from waste spent films.

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“…Aradottir and Olsson reported PEth recovery to be 25% higher when 2‐propanol was added before hexane compared to when a mixture of the two compounds was added, probably due to the phospholipids from the cell membranes becoming more available after the lipid‐protein linkages are broken by adding 2‐propanol. Protein precipitation (PPT) and solid phase extraction (SPE) have also been used for sample preparation of PEths from biological samples . Recently, Andreassen et al described a high throughput UHPLC‐MS/MS method for determination of PEth 16:0/18:1 in whole blood using 96‐well PPT with 2‐propanol as organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS

Berg

Eliassen

Jørgenrud

et al. 2018

Clinical Laboratory Analysis

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For the first time, 96-well SLE was used for preparation of a PEth homologue in biological samples. A mixture of tert-butyl methyl ether and 2-propanol (5:1, v:v) was chosen as organic eluent based on an evaluation of extraction recovery, purity of extracts, and evaporation time. The developed UHPLC-MS/MS method can be used for high throughput analyses and sensitive determinations of PEth 16:0/18:1 in whole blood.

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Solid-phase extraction of the alcohol abuse biomarker phosphatidylethanol using newly synthesized polymeric sorbent materials containing quaternary heterocyclic groups

Cited by 5 publications

References 24 publications

Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Paradigm Shift in the Arena of Sample Preparation and Bioanalytical Approaches Involving Liquid Chromatography Mass Spectroscopic Technique

Synthesis of Sulfur-Grafted Chitosan Biopolymers and Improvement to Their Sorption of Silver Ions from Different Aqueous Solutions

Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS

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