Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man

Matsuda, Ikuo; Hao, Hiroyuki; Zozumi, Masataka; Koishi, Kenji; Matsumoto, Tomohiro; Kaibe, Nobuaki; Fujiwara, Yoshinori; Sasako, Mitsuru; Hirota, Seiichi

doi:10.1016/j.prp.2009.07.014

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…Interestingly, a few cases of extensively calcified pancreatic solid pseudopapillary neoplasm have been recently reported in the literature (7,8); the imaging findings presented in these reports were very similar in appearance to those shown in our cases. Due to the similarity of these radiological findings, we suggest that GIST should therefore be included in the differential diagnosis of calcified intraabdominal masses located near the stomach or pancreas.…”

Section: Discussionsupporting

confidence: 87%

Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

et al. 2012

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Gastrointestinal stromal tumors (GISTs) can present with focal calcification. However, the presence of extensive calcification that constitutes the major portion of a GIST is extremely rare and can be associated with diagnostic pitfalls. We herein present the first two cases of rare gastric GIST with predominantly calcified components that mimicked pancreatic solid and pseudopapillary neoplasms with extensive calcification. In patients presenting with hyper-dense, heavily calcified masses in the abdominal cavity, the possibility of GIST should be considered in the differential diagnosis. A careful search for cellular areas and the judicious application of immunostaining will thus make it possible to make a correct diagnosis.

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Section: Discussionsupporting

confidence: 87%

Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

et al. 2012

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“…Mutations of CTNBB1 in SPN were first demonstrated in 2001 (7). We reviewed and analyzed the mutations of CTNBB1 in 123 pancreatic SPN cases that retrieved from PubMed search encompassing the years 2001 through 2012 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Of these 123 cases, 111 (90.2%) of the patients with pancreatic SPN demonstrated mutations in CTNNB1 exon 3 (Fig.…”

Section: Discussionmentioning

confidence: 99%

Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

et al. 2013

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Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was specifically observed in the tumor cells. Further, the tumor cells were shown to harbor a missense mutation in exon 3 of CTNNB1. We also present a review of the literature describing the clustering of CTNNB1 mutations in patients with SPN.

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“…In a previous study of SPTs by Machado et al, 6 in which there were seven male patients, the mean age was higher among male patients (37 years vs 25 years). Matsuda et al 13 reported a case of SPT of the pancreas in a 76-year-old male and Tanino et al 14 reported a case of a 58-year-old male with SPT. However, Takahashi et al 7 reported that the mean age of the seven male patients with SPT in their group was 45.0 years and that of the seven female patients in the group was 45.5 years.…”

Section: Discussionmentioning

confidence: 99%

Multidetector CT imaging features of solid pseudopapillary tumours of the pancreas in male patients: distinctive imaging features with female patients

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et al. 2014

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Objective: To describe multidetector CT imaging features of solid pseudopapillary tumours (SPTs) in male patients and to compare these imaging features with those found in female patients. Methods: The institutional review board approved this retrospective study. We included the CT images of 72 patients (M:F 5 12:60; mean age, 35.0 years) diagnosed with SPT by histology. CT images were reviewed on the following: location of the tumour, maximal diameter, shape, margin and the fraction of the tumour composition. Statistical differences in CT imaging features were analysed.

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Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man

Cited by 9 publications

References 11 publications

Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

Gastrointestinal Stromal Tumors of the Stomach with Extensive Calcification: Report of Two Cases

Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

Multidetector CT imaging features of solid pseudopapillary tumours of the pancreas in male patients: distinctive imaging features with female patients

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