Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts

Jadhav, Namdeo; Irny, Preeti; Patil, Udaykumar

doi:10.1016/j.jddst.2017.01.009

Cited by 34 publications

(14 citation statements)

References 23 publications

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“…Progesterone as a model drug was successfully formulated using Neusilin® US2 as carrier and showed improved dissolution as compared to conventional forms of the same. 46 Same was confirmed by Hentzschel et al for Griseofluvin. 24 In one of its kind, a different perspective upon the Liquisolid systems was perceived by Lu M. et al where they employed Raman Spectroscopy in screening of Tadalafil Liquisolid systems which indicated loss in crystallinity demonstrated by alteration of intensity as compared to pure drug.…”

Section: Literature Review 61 In Dissolution Enhancementmentioning

confidence: 58%

“…Carrier-Porous materials having high specific surface area & liquid absorption capacity can be employed as carriers which can absorb the resulting Drug Solution to convert it into a dry looking free flowing powder. Some examples are Microcrystalline Cellulose ( Avicel PH 101, 102, 200) [8][9][10][11][12][13][19][20][21][22][23]27,[30][31][32][33] , Amorphous Cellulose, Ethyl Cellulose 28 , Dibasic Calcium Phosphate, Fujicalin ® (Synthetic Dibasic Calcium Phosphate Anhydrous) 21 , Neusilin ® US2 (Synthetic Amorphous Aluminometasilicate) 21,46,56 , Eudragit ® (RL, RS) 14,28,31,33 , HPMC K4M (Hydroxy propyl ethyl cellulose) 33 , Starch 26 , Lactose 12,27,34 , Mannitol 34 and Florite ® (Calcium Silicate) 21 .…”

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confidence: 99%

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Liquisolid Technology: Preparation, Characterization and Applications

Gorle

Chopade

2020

J. Drug Delivery Ther.

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With the advent of high throughput screening, drugs are emerging to be more lipophilic and less hydrophilic. Liquisolid Technology aims at solubility enhancement of such entities via cosolvency concept in a relatively minimalistic setup where there is no need of sophisticated machinery and is cost effective. It involves constituting a drug into molecular dispersion via a non-volatile solvent and then transforming it into a dry looking, free flowing compressible powder. This article aims at mapping Liquisolid Technology where its preparation techniques and potential applications are reviewed. An overview of the performance of Liquisolid in areas of dissolution enhancement, zero order release, photostability enhancement, liquipellets and its role in natural product formulations is recorded for a number of drugs. Keywords: Liquisolid, Dissolution Enhancement, Flowability, Compressibility, Cosolvency

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Section: Literature Review 61 In Dissolution Enhancementmentioning

confidence: 58%

mentioning

confidence: 99%

Liquisolid Technology: Preparation, Characterization and Applications

Gorle

Chopade

2020

J. Drug Delivery Ther.

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“…Due to their high specific surface area and biocompatibility, silica materials are usually the material of choice for inorganic-based controlled drug delivery systems [ 38 , 40 , 41 ]. The use of porous silicas as materials for drug delivery ranges from amorphous solid dispersions and liquid–solid drug delivery systems to mesoporous silica nanoparticles [ 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

2021

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The objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil—drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated.

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“…Liquisolid compacts are prepared by using the below method to produce tablets or capsules, whereas the liquisolid Microsystems are based on a new concept which employs similar methodology combined with the inclusion of an additive, e.g., polyvinylpyrrolidone (PVP) in the liquid medication which is incorporated into the carrier and coating materials to produce an acceptably flowing admixture for encapsulation 11 . The technique of liquisolid compaction has been used successfully to improve the invitro release of poorly soluble drugs such as piroxicam 12 , progesterone 13 , repaglinide 14 , furesomide 15 .…”

Section: Liquisolid Systemmentioning

confidence: 99%

A Promising Technique to Improve the Solubility by Liquisolid Compaction Technology

Naik¹,

Sunder

Manchikanti

2018

J. Drug Delivery Ther.

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About 60-70% of the drugs synthesized are poorly soluble and comes under BCS Class-II&IV. Now it is a challenging situation during the development of different dosage forms for pharmaceutical industries because solubility of the drug is the rate limiting step. Based on the solubility, the dissolution, bioavailability & therapeutic effect is dependent. To overcome this consequence a novel technique -Liquisolid compact is used by dissolving the poorly soluble drug in a non-volatile solvent that improves wettability & decreases the surface tension and ensures drug molecular dispersion in the formulation to increase the solubility of the drug. This admixture of drug loaded solution is blended with carrier adsorption & coating material (adsorption) that has free flowing and compressible powder properties.

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Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts

Cited by 34 publications

References 23 publications

Liquisolid Technology: Preparation, Characterization and Applications

Liquisolid Technology: Preparation, Characterization and Applications

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

A Promising Technique to Improve the Solubility by Liquisolid Compaction Technology

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