2015
DOI: 10.1016/j.jpba.2015.02.047
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Solid state compatibility study and characterization of a novel degradation product of tacrolimus in formulation

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Cited by 14 publications
(11 citation statements)
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“…Figure 6 depicts the 1 H NMR spectra for TAC-NMF in CDCL 3, TAC-NMF and blank-NMF in D 2 O and TAC in CDCL 3 . The spectra for TAC in CDCL 3 are in accordance with previously published results [45]. A sharp peak for oxyethylene group -CH 2 -CH 2 -O (δ = 3.8 ppm), hydroxyl protons (PEG) (δ = 4.5 ppm), and moderate signals for methylene =CH 2 (δ = 1.3 ppm) and methyl -CH 3 (δ = 0.7 ppm) groups of HCO-40 amphiphilic surfactant polymer were recorded.…”
Section: Nanomicellar Dilution Studysupporting
confidence: 91%
“…Figure 6 depicts the 1 H NMR spectra for TAC-NMF in CDCL 3, TAC-NMF and blank-NMF in D 2 O and TAC in CDCL 3 . The spectra for TAC in CDCL 3 are in accordance with previously published results [45]. A sharp peak for oxyethylene group -CH 2 -CH 2 -O (δ = 3.8 ppm), hydroxyl protons (PEG) (δ = 4.5 ppm), and moderate signals for methylene =CH 2 (δ = 1.3 ppm) and methyl -CH 3 (δ = 0.7 ppm) groups of HCO-40 amphiphilic surfactant polymer were recorded.…”
Section: Nanomicellar Dilution Studysupporting
confidence: 91%
“…Sometimes chemical moieties of the drug can transform into degradants in presence of Magnesium stearate. There were several literature exists for the degradants formed in presence of magnesium stearate [41]- [45].…”
Section: Magnesium Stearatementioning
confidence: 99%
“…Tacrolimus is macrolide drug that is widely used as a potent immune suppressant. Tenja Rozman Peterka et al [41] reported the formation of alpha-hydroxy acid from the parent tacrolimus through Benzilic acid type rearrangement reaction in the presence of magnesium stearate (Figure 27). This reaction occurred in the presence of divalent metallic cations at higher pH values.…”
Section: Benzilic Acid Rearrangement Of Tacrolimus Due To Magnesium Smentioning
confidence: 99%
“…Therefore, different degradation pathways such as dehydration, isomerization of double bonds, hydrolysis, rearrangement, and epimerization can be done on it. 17 Rotation of amide bond consequences an equilibrium between trans and cis rotamers of tacrolimus in the pipecolic acid moiety. 18 Pipecolic acid moiety is often considered a vital factor for the biological activities of some natural pharmaceutical products from microbial sources.…”
Section: Introductionmentioning
confidence: 99%