Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines

Abstract

We present green, highly atom economic, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by...

Hydrogen bonding-promoted tunable approach for access to aza-bicyclo-[3.3.0]octanes and cyclopenta[b] pyrroles

“…The poor nucleophilicity of aniline nitrogen generally hinders its addition onto carbon-based π-systems and this is often circumvented under high pressure/temperature. 18 This current development, however, needs no such requirement. Furthermore, the addition of aniline to the electron-poor alkyne solely occurs through the N-centre in the present reaction and does not involve the para -position of the phenyl ring.…”