Solid‐Supported Synthesis of Isoxazole‐Substituted 1,4‐Dihydropyridines by Modified Hantzsch Method and Their Aromatization

Synthesis, structural and conformational properties, and gas phase reactivity of 1,4-dihydropyridine ester and ketone derivatives

“…7, 8 The use of this class of molecules as a scaffold to develop novel antitumor therapies has been recently proposed. 9 For example, the dihydropyridine DP7 (Scheme 1) has been shown to be a potent inhibitor of P-gb and therefore has potential to become a good candidate in novel treatments for cancers that have developed multi drug resistance (MDR). Considering the promising activity of DP7, we have embarked on a research program aimed at introducing additional diversity in the 1,4-dihydropyridine moiety with the obvious tasks of (i) obtaining more powerful P-gp inhibitors; (ii) gaining an insight on the tridimensional properties of these products, as their chemical properties are linked to the observed biological activity.…”

An efficient and modified biginelli one‐pot synthesis of new isoxazole substitted 3,4‐dihydropyrimidin‐2(1H)‐ones and thiones catalyzed by VCl3

“…of benzaldehyde with 1 equiv. of N-(5-methyl-3-isoxazolyl)-3-oxobutanamide [21,22] and 1 equiv. of urea/thiourea in presence of VCl 3 in acetonitrile has been performed under refluxing conditions for 2-4 hr.…”

Applications of bismuth(iii) compounds in organic synthesis

“…321 Rajanarendar and co-workers have reported the aromatization of isoxazole-substituted 1,4-dihydropyridines using BiONO 3 adsorbed on acidic alumina (Scheme 204). 322 Azarifar and Maleki have reported that Bi(NO 3 ) 3 Á5H 2 O is an effective oxidizing agent for the aromatization of 1,3,5-trisubstituted 2-pyrazolines to pyrazoles in CH 3 COOH under microwave irradiation (Scheme 205). 323 Sato and co-workers have reported a Bi(OTf) 3 -catalyzed conversion of acetophenones to 1,3-5-triarylbenzenes (Scheme 206).…”