1994
DOI: 10.1007/s001050050093
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Solit�res Basaliom eines 10j�hrigen Jungen

Abstract: It is rare for solitary basal cell cancer not to be associated with the naevoid basal cell carcinoma syndrome (NBCCS), xeroderma pigmentosum, an organoid nevus or X-ray therapy in children (to date 86 cases have been documented in the literature. Aetiologically, the tumours might be a forme fruste of the NBCCS or they might follow a somatic point mutation of keratinocytes. Up to now, data on the repair mechanism following UV-induced DNA damage are not available in these patients. We report on a 10-year-old boy… Show more

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“…Besides, exposure to arsenic, tar and X-rays are known to be predisposing factors for the development of BCC's. Sporadic BCC's in children and adolescents under 20 years of age are rare [Baum and Hog, 1994]. If they are observed, hereditary predisposing factors (for which a tendency to develop multiple BCC's at an early age is characteristic) like decreased DNA repair (xeroderma pigmentosum), familial BCC's [Guarneri et al, 2000] or the basal cell naevus syndrome (Gorlin's syndrome) must be excluded.…”
Section: Discussionmentioning
confidence: 99%
“…Besides, exposure to arsenic, tar and X-rays are known to be predisposing factors for the development of BCC's. Sporadic BCC's in children and adolescents under 20 years of age are rare [Baum and Hog, 1994]. If they are observed, hereditary predisposing factors (for which a tendency to develop multiple BCC's at an early age is characteristic) like decreased DNA repair (xeroderma pigmentosum), familial BCC's [Guarneri et al, 2000] or the basal cell naevus syndrome (Gorlin's syndrome) must be excluded.…”
Section: Discussionmentioning
confidence: 99%