Solitary cavities of the lung: diagnostic implications of cavity wall thickness

Woodring, John H.; Fried, A M; Chuang, V P

doi:10.2214/ajr.135.6.1269

Cited by 182 publications

(84 citation statements)

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“…Malignant vs. benign character of the lesion is indicated by the wall thicknesswalls up to 4 mm are in 92% indicative of benign lesion, while walls thicker than 15 mm are in 95% suggestive of malignancy [35].…”

Section: Morphologymentioning

confidence: 99%

“…Solid lesions stable for 2 years are also considered benign (with volume doubling time being taken into consideration). However, one should keep in mind that this rule does not apply to non-solid lesions, which grow much slower with doubling time as long as 4 years [35]. An additional difficulty associated with the- se lesions is due to the problems with accurate and repeatable measurements of the solid and the ground glass opacity parts; therefore, computer assisted diagnosis (CAD) are used more and more commonly to achieve this end [36].…”

Section: Growth Ratementioning

confidence: 99%

See 1 more Smart Citation

Solitary Pulmonary Nodule—The Role of Imaging in the Diagnostic Process

Paśnik¹,

Bestry²,

Roszkowski‐Śliż³

2017

Advances in Respiratory Medicine

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A solitary pulmonary nodule is a round opacity less than 30 mm in diameter surrounded by normally aerated lung tissue. Determination of the character of the lesion following its detection (particularly when the identification was incidental) may require a complex diagnostic process. In most cases, nodules are benign in character; however, the probability of malignancy increases significantly for part-solid lesions. The main features that describe the solitary pulmonary nodule in computed tomography scans include their size, shape, density, presence of calcification and rate of growth. PET-CT examination provides additional information on the metabolic activity of the lesions, and MRI is helpful in assessment of local invasion of surrounding structures. Due to limited availability and highly specialized character, these examinations are not routinely used. Therefore, despite development of other imaging modalities, computed tomography remains the most important and crucial diagnostic tool. Clinical risk factors such as age or smoking status are very important for evaluation of the likelihood of malignancy of a nodular lesion. Due to the multidisciplinary nature of data required for complex assessment of a solitary nodular lesion, management routines are needed in the diagnostic process such as those proposed by the Fleischner Society.

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Section: Morphologymentioning

confidence: 99%

Section: Growth Ratementioning

confidence: 99%

Solitary Pulmonary Nodule—The Role of Imaging in the Diagnostic Process

Paśnik¹,

Bestry²,

Roszkowski‐Śliż³

2017

Advances in Respiratory Medicine

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“…Of course, measured wall thickness will depend on the imaging technique used (plain radiography or computed tomography). Two studies examined the predictive utility of cavity wall thickness in solitary lung cavities as measured by plain radiography (399,400). Those studies found that the measurement of the cavity wall thickness at its thickest section was most useful in predicting whether the cavity was of malignant versus nonmalignant etiology.…”

Section: Characteristics Of Cavities Used For Differential Diagnosismentioning

confidence: 99%

Cavitary Pulmonary Disease

2008

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SUMMARY A pulmonary cavity is a gas-filled area of the lung in the center of a nodule or area of consolidation and may be clinically observed by use of plain chest radiography or computed tomography. Cavities are present in a wide variety of infectious and noninfectious processes. This review discusses the differential diagnosis of pathological processes associated with lung cavities, focusing on infections associated with lung cavities. The goal is to provide the clinician and clinical microbiologist with an overview of the diseases most commonly associated with lung cavities, with attention to the epidemiology and clinical characteristics of the host.

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“…Of the non-small cell lung cancer subtypes, several studies have shown squamous cell carcinoma to be one of the more rapidly growing tumor subtypes. 7,8 Woodring et al 9,10 found the thickest section of a cavity wall to be the most useful factor in differentiating a malignant from a nonmalignant etiology of cavity and found that most cavities (Ͼ 90% cases) with a wall thickness of Ͼ 15 mm were malignant. Although chronic inflammation and scarring caused by the infection can lead to cancer, malignant tumors in turn can lead to immunosuppression and thereby promote opportunistic infections.…”

Section: Discussionmentioning

confidence: 99%