Solitary dorsal intramedullary schwannoma

Herregodts, Patrick; Vloeberghs, Michel; Schmedding, Eric; Goossens, A.; Stadnik, Tadeusz; D’Haens, Jean

doi:10.3171/jns.1991.74.5.0816

Cited by 61 publications

(45 citation statements)

References 25 publications

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“…5,7,8,14,18,22) based on their cellular pleomorphism, anaplasia, increased mitoses, and local invasion. Malignant forms of schwannoma were poorly circumscribed and infiltrative.…”

Section: Resultsmentioning

confidence: 99%

“…8,10,19 In humans, schwannoma accounts for an estimated 8% of intracranial 3 and 29% of primary spinal tumors. 8,25 In humans, clinical and morphopathologic distinctions are recognized between schwannoma (World Health Organization [WHO] grade I), neurofibroma (WHO grade I), and malignant peripheral nerve sheath tumor (MPNST) WHO grade III and IV classification. Schwannoma in humans is considered a benign slowly growing neoplasm located anywhere in the PNS, but its most frequent intracranial site is the vestibular segment of the eighth cranial nerve.…”

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confidence: 99%

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Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath Tumors

2001

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Abstract. Thirty-four peripheral nerve sheath tumors of four domesticated animal species were characterized and assayed for point mutation of the neu oncogene. Based on their morphoimmunophenotype, 32 tumors were classified as schwannomas. Schwannoma morphology was characterized by the presence of Antoni type A and B pattern and immunoreactivity for S-100 protein and vimentin. Two anaplastic and metastatic tumors originating from spinal cord root, immunonegative for S-100 protein and positive for vimentin, were classified as malignant peripheral nerve sheath tumors (MPNSTs). Four malignant schwannomas and two MPNSTs expressed a point mutation of the neu oncogene by the polymerase chain reaction-restriction fragment length polymorphism method. The finding of neu oncogene mutation could be a useful diagnostic genetic marker in the malignant form of peripheral nerve sheath tumors in animals.

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“…5,7,8,14,18,22) based on their cellular pleomorphism, anaplasia, increased mitoses, and local invasion. Malignant forms of schwannoma were poorly circumscribed and infiltrative.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath Tumors

2001

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“…The pathogenesis of intramedullary schwannoma is still not clear, and various hypotheses have been proposed. The postulated pathogeneses of these tumors' origin include Schwann cells along the intramedullary perivascular nervous plexus 7,14,16) , focal intramedullary proliferation of Schwann cells in reaction to chronic disease or trauma 1,11) , ectopic Schwann cells originating from migrating neural crest cells 8,12,17,18) , and Schwann cells related to aberrant intramedullary myelin fibers 11) . Also, Schwann cells in the posterior nerve root at the root entry zone are assumed to be one of pathogeneses of intramedullary tumors 13,19) .…”

Section: Discussionmentioning

confidence: 99%

Thoracic Intramedullary Schwannoma Accompanying by Extramedullary Beads-Like Daughter Schwanommas

Ryu

Lee

et al. 2011

J Korean Neurosurg Soc

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Thoracic intramedullary schwannomas are rare spinal cord tumors. Most of these tumors have been reported as a single lesion in the spinal cord. The authors report the first case of intramedullary schwannoma accompanying by extramedullary beads-like daughter masses of the thoracic spine. A 68-year-old male presented with walking disturbance and decreased sensation below T10 dermatome. Imaging workup revealed an intramedullary mass at T6 and T7. T6 and T7 laminectomy and mass removal were performed. Intraoperatively, extramedullary beads-like daughter masses along the nerve roots adjacent to intramedullary mass were identified. Total removal of intramedullary lesion and partial resection of extramedullary masses were done. Histological analysis confirmed the diagnosis of schwannoma. The patient could ambulate independently at postoperative 1 month without any neurological sequelae. The authors experienced a surgical case of intramedullary schwannoma accompanying by extramedullary beads-like same pathologies in the thoracic spine.

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“…Apesar da localização posterior predominar, alteração de sensibilidade profunda é menos freqüentemente encontrada que fraqueza motora e dor. Na história há freqüentemente menção de deficiência motora unilateral ou predominantemente unilateral, com períodos alternados de remissão e agravamento, por vezes acompanhados de amiotrofia 11,16 . Relatos mais recentes reforçam a impossibilidade de localização das lesões baseada apenas em dados da avaliação clínica" 15 .…”

Section: Discussionunclassified

Scwannoma intramedular: relato de caso

Botelho

Kalil

Masini

1996

Arq. Neuro-Psiquiatr.

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RESUMO -A localização intramedular de schwannoma é rara, correspondendo a 0,3% dos tumores nesta topografia. Os autores relatam o caso de uma paciente leucoderma de 52 anos, que apresentou sintomas de compressão devido à presença de schwannoma intramedular localizado em nível de C4 a C6. Não foram encontrados sinais de neurofibromatose, enfermidade que tem sido associada ao desenvolvimento da lesão. Os exames de ressonância magnética nuclear e a biópsia transoperatórIa foram fatores decisivos no planejamento e na execução do tratamento, ao estabelecer as características, localização e diagnóstico da lesão. Sua boa delimitação e sua localização posterior facilitaram a exérese total. O exame histopatológico transoperatórIo permitiu a instituição de procedimento cirúrgico adequado. A célula de Schwann não é normalmente encontrada no sistema nervoso central e sua presença neste local tem sido objeto de várias teorias expostas no texto deste trabalho, que aborda também revisão de aspectos clínicos, diagnóstico por imagem, patologia, diagnóstico diferencial e tratamento dos schwannomas. E provável que, com os métodos propedêuticos atualmente disponíveis, venha a ser encontrado maior número destas lesões no futuro. PALAVRAS-CHAVE: schwannoma, medula espinhal, abordagem diagnostica e terapêutica. Intramedullary schwannoma: case reportABSTRACT -The intramedullary localization of schwannomas is rare, corresponding to 0.3% of all intraspinal tumors. The authors report the case of a 52 year-old white female patient that presented with symptoms of spinal compression by the presence of an intramedullary schwannoma at the level C4-C6. There were no symptoms of neurofibromatosis, entity frequently related to the lesion. The magnetic resonance imaging examination and the per-operatory biopsy were decisive factors in planning and executing the treatment , by establishing the characteristics, location and diagnosis of the lesion. Its delimitation and posterior location have facilitated total surgical exeresis. The transoperatively histopathologic examination allowed adequate surgical procedure. The Schwann cell is not found normally in the central nervous system and its presence in this site has been subject of many theories exposed in this paper, which proposes comprehensive review of the clinical aspects, imaging diagnosis, pathology, differential diagnosis and treatment of schwannomas. It is probable that, with the advances verified in the available diagnostic methods, a greater number of these lesions may be diagnosed in the future. KEY WORDS: schwannoma, spinal cord, diagnostic and therapeutic approaches.Os schwannomas (neurilemomas ou neurinomas) são neoplasias benignas derivadas das células de Schwann do sistema nervoso periférico. Estas células são responsáveis pela formação da bainha de mielina -sendo análogas em função aos oligodendrócitos do sistema nervoso central (SNC) -e podem estar excepcionalmente localizadas no parênquima encefálico ou medular. Ao contrário de

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Solitary dorsal intramedullary schwannoma

Cited by 61 publications

References 25 publications

Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath Tumors

Point Mutation of neu Oncogene in Animal Peripheral Nerve Sheath Tumors

Thoracic Intramedullary Schwannoma Accompanying by Extramedullary Beads-Like Daughter Schwanommas

Scwannoma intramedular: relato de caso

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