Solitary Epibulbar Neurofibroma in Older Adult Patients

Tanaka, Thaís Shiota; Elner, Victor M.; Demirci, Hakan

doi:10.1097/ico.0000000000000370

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…As previously mentioned, a corneal nerve sheath neoplasm has been reported in the horse . Furthermore, there have been reports of epibulbar, limbal, and corneal neurofibromas in the human ophthalmologic literature.…”

Section: Discussionmentioning

confidence: 83%

Primary bilateral corneal nerve sheath neoplasm in a dog

Leis

Salpeter

Bauer

et al. 2016

Veterinary Ophthalmology

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A 15-year-old, neutered male, Shih Tzu cross developed progressive corneal stromal thickening and vascularization of the right eye, and 5 months later, of the left eye. Both eyes became blind due to extensive corneal opacification and were enucleated. Light microscopic examination revealed a diffuse corneal infiltrate of neoplastic mesenchymal cells, and immunohistochemistry revealed diffuse cytoplasmic vimentin immunoreactivity and variable cytoplasmic and nuclear immunoreactivity for S100 in the neoplastic cells. Transmission electron microscopy revealed desmosomes between contiguous cells, thread-like cytoplasmic processes coated with basement membrane, extracellular bundles of collagen, and axonal degeneration consistent with features of a nerve sheath neoplasm. This is the first report of primary, bilateral corneal nerve sheath sarcoma in a canine.

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Section: Discussionmentioning

confidence: 83%

Primary bilateral corneal nerve sheath neoplasm in a dog

Leis

Salpeter

Bauer

et al. 2016

Veterinary Ophthalmology

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“…49 Myxoid neurofibroma can resemble a myxoma and develop on the surface of the globe. 51 Both contain readily identified mast cells in the loose stroma. The former is somewhat more cellular and vascularized than the latter.…”

Section: Differential Diagnosis Of Primary Conjunctival Lesionsmentioning

confidence: 99%

Epibulbar Proliferative Fasciitis, a Variant of Nodular Fasciitis: A Differential Diagnosis of Conditions With Focal or Diffuse Myxoid Stromas

Barrantes

Mihm

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe the clinical and pathologic features of a case of epibulbar proliferative fasciitis and to compare it with other focal or diffuse myxoid lesions. Methods: A clinical, histopathologic, and immunohistochemical analysis was performed. The clinical history, photographic documentation, history, and referred slides were reanalyzed. Additional immunohistochemical stains were performed at our institution. Results: A 68-year-old woman developed over a week a brightly vascularized and focally hemorrhagic placoid lesion on the temporal side of the OS. She had had earlier augmentation breast surgery that had been mistakenly initially reported to us to be for breast carcinoma. Hematoxylin- and eosin-stained reactions revealed microscopically a spindle cell lesion with an intact nonkeratinizing epithelium and a background myxoid stroma with prominent capillaries and a light dispersion of small T-cell lymphocytes. Most striking among the spindle cells were some widely separated large atypical cells. The atypical cells were cytokeratin positive, but an expansive panel of immunohistochemical stains for breast carcinoma was negative. The lesion was diagnosed as proliferative fasciitis and has not recurred after 1-year follow up. Conclusion: A rapidly evolving conjunctival lesion is unlikely to be a primary or metastatic carcinoma. In the current case, the large ganglioform or rhabdomyoblast-like cells displayed diffuse cytokeratin positivity, still consistent with a mesenchymal or connective tissue cell lineage. Cytokeratin expression has been a finding previously reported in connective tissue tumors and in lymphoma cells. While the current lesion clinically resembles a conventional nodular fasciitis, the presence of the large atypical cells can lead to the misdiagnosis of a sarcoma, which typically displays a much higher Ki-67 proliferation index in comparison with nodular/proliferative fasciitis.

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“…1) биомикроскопия -субконъюнктивальное новообразование, беспигментное, полупрозрачное, желатинового цвета, окололимбально с носовой стороны [39].…”

Section: Ch I Ld Neurology R U S S I a N J O U R N A L O Funclassified

Modern Technologies in the Diagnosis of the Vision Organ Pathology in Patients With Neurofibromatosis Type I (Review of Literature)

Ольшанская¹,

Shnaider²,

Дмитренко³

et al. 2016

Rus. ž. det. nevrol.

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Solitary Epibulbar Neurofibroma in Older Adult Patients

Abstract: Solitary epibulbar neurofibroma in older adult patients without systemic neurofibromatosis is rare but should be considered in the differential diagnosis of epibulbar tumors.

Cited by 6 publications

References 9 publications

Primary bilateral corneal nerve sheath neoplasm in a dog

Primary bilateral corneal nerve sheath neoplasm in a dog

Epibulbar Proliferative Fasciitis, a Variant of Nodular Fasciitis: A Differential Diagnosis of Conditions With Focal or Diffuse Myxoid Stromas

Modern Technologies in the Diagnosis of the Vision Organ Pathology in Patients With Neurofibromatosis Type I (Review of Literature)

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