Solitary extramedullary plasmacytoma of the nasopharynx: The role of flow cytometry

Loucari, Constantinos; Foukas, Periklis; Spathis, Aris; Tsakiraki, Zoi; Apostolopoulou, Christina; Thomopoulos, Thomas; Bouchla, Anthi; Oikonomopoulos, Nikolaos; Maragkoudakis, Pavlos; Pappa, Vasiliki; Papageorgiou, Sotirios

doi:10.1016/j.oraloncology.2021.105351

Cited by 2 publications

(2 citation statements)

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“…It may be difficult to distinguish EMPs from a low‐grade BCL with significant plasma cell differentiation. Flow cytometry may be helpful in these cases, as EMPs rarely express CD45 and CD19 1880 …”

Section: Sinonasal Lymphomamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Section: Sinonasal Lymphomamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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“…В такой ситуации, возможно, необходимо дополнительно применять другие диагностические методы иммунофенотипи рования. Так, описан случай диагностики плазмокле точной опухоли головы и шеи с применением имму нофенотипирования опухолевой ткани методом проточной цитометрии [17]. Особенно полезным, по мнению авторов, этот дополнительный метод ди агностики будет в случае, когда ИГХданные не по зволяют однозначно дифференцировать плазмокле точную дискразию и Вклеточную неходжкинскую лимфому.…”

Section: диагностика и лечение множественной миеломыunclassified

Plasma cell tumors of the head and neck. Analysis of diagnostic difficulties based on literature and own data

et al. 2021

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Background. Extramedullary plasmacytoma (EP) of soft tissues, which in most cases affects the organs of the head and neck region, is a relatively rare malignant tumor. Until now, there are no consensus approaches to the diagnosis and treatment of EP. Differentiating EP from other types of non-Hodgkin’s lymphomas is difficult. There are difficulties in the differential diagnosis of EP and carcinomas in the head and neck region. Given the rare occurrence of this nosological form, the frequency of diagnostic errors is quite high, which dictates the need for a thorough description of each head and neck EP case.Objective of the study: analysis of possible difficulties and reasons for incorrect interpretation of diagnostic data, and treatment for head and neck EP.Materials and methods. Clinical and morphoimmunological data of 97 primary patients with B-cell non-Hodgkin’s lymphomas (B-NHLs) of the head-neck region were analyzed.Results. In our cohort we identified 2 tumor cases of a plasma cell nature, which amounted to 2 % among all B-NHLs. In one case, the process was located in the nasal cavity and clinically manifested itself with nosebleeds. The second case is a lesion of the mouth floor, primarily with the ulcer formation. In the first cases, at diagnosis, the immunohistochemistry (IHC) test was performed after patient’s chemotherapy and radiation treatment, which distorted the tumor immunophenotype. In the second cases with extensive process in maxillary sinuses, a complete and very detailed IHC test was carried out; however the data did not allow for a definitive diagnosis. Difficulties apparently arose in the interpretation of CD38 expression – main marker of plasmacytic line cells, as well as due to the unusual morphology.Conclusion. The described diagnostic situations dictate the need for a comprehensive algorithm in the diagnosis of head and neck tumors. It is advisable to perform an extended morpho-immunophenotypic study of the tumor (IHC, immunocytology, flow cytometry, etc.), if a tumor of a plasma cell nature is suspected, a morpho-immunological study of the bone marrow is indicated.

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Solitary extramedullary plasmacytoma of the nasopharynx: The role of flow cytometry

Cited by 2 publications

References 11 publications

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Plasma cell tumors of the head and neck. Analysis of diagnostic difficulties based on literature and own data

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