Solitary fibrous tumor: Histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites

An Aggressive Solitary Fibrous Tumor with Evidence of Malignancy: A Rare Case Report

“…Peripheral nerve sheath tumors may share some histologic similarities but unlike SFT they exhibit moderare to strong positivity for S-100 [5,16]. Thus, immunohistochemistry plays a pivotal role, in diagnosis, especially CD34 positively although not specific but along with compatible histopathological background is very helpful in differentiating SFT from other lesions [1,3,13,23].…”

“…It was once referred to as localized fibrous mesothelioma because it was thought to be of submesothelial origin [1]. Since then, numerous hypotheses have been laid down regarding their origin and are now believed to arise from dendritic mesenchymal cells [2].…”

A Rare Case of a Recurrent Giant Solitary Fibrous Tumor of the Ciliary Body of the Orbit

“…These tumors are categorized as tumors of 'intermediate malignancy' under the World Health Organization (WHO) classification of soft tissue tumors [3]. Although once thought to be mesothelial in origin, SFT is now considered a tumor of mesenchymal fibroblast-like cell origin [1].…”

“…Orbital SFTs were virtually non-existent or misdiagnosed until its characteristic histological features, including the strong and diffuse immunoreactivity to CD 34 was described [1,5]. SFTs can occasionally demonstrate great variability in its morphology and shares histologic features with other mesenchymal tumors, which may contribute to its misdiagnosis.…”

“…Solitary fibrous tumors (SFTs) are uncommon spindle-cell tumors of mesenchymal origin [1]. They are most commonly reported to arise from the pleura and also from various other extra-pleural sites, including the mediastinum, lung, liver, breast, retroperitoneum, spine, meninges and extra-cranial head and neck regions such as the orbit, sino-nasal cavity, salivary gland, thyroid gland and along the upper aero-digestive tract [2].…”