Solitary fibrous tumor of the pancreas

Baxter, Andrew; Newman, Elliot; Hajdu, Cristina

doi:10.1093/jscr/rjv144

Cited by 21 publications

(12 citation statements)

References 8 publications

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“…In our case, the patient presented with abdominal pain and jaundice. The patients' age ranges from 24-78 years at diagnosis [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Although extrapleural SFT has no gender bias reported, the current pancreatic cases have female to male ratio of 12 : 3.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemically SFT expresses CD34 and vimentin in 80-90% of cases and CD99 and bcl-2 in 70% of cases. They are usually negative for c-kit (CD117), smooth muscle actin, desmin, S-100 protein and cytokeratins which are markers of GIST, leiomyosarcoma, schwannoma, and fibromyxoid sarcoma, respectively [4,9]. Diffusely positive staining for CD34, vimentin and CD99, focally positive for bcl-2, nuclear beta-catenin and actin and negative for CD117, EMA, Caldesmon, Desmin, S100 and Cytokeratins has been obtained in our case.…”

Section: Discussionmentioning

confidence: 99%

“…Pancreas is an extremely rare abdominal localization of the solitary fibrous tumor (SFT) with only 16 cases reported to date [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. It usually grows asymptomatically for a long time before a diagnosis can be made on the basis of symptoms and/or mechanical complications.…”

Section: Introductionmentioning

confidence: 99%

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Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

Spasevska¹,

Janevska²,

Janevski

et al. 2016

Prilozi

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Pancreas is an extremely rare abdominal localization of the solitary fibrous tumor (SFT). It usually grows asymptomatically for a long time before a diagnosis can be made on the basis of symptoms and/or mechanical complications. Due to the rarity and nonspecific clinical presentation, this entity is diagnostically challenging. We present a 47-year-old man with a history of progressive epigastric pain for the last two weeks, and jaundice, who was admitted to hospital for further investigation. Cystadenocarcinoma was suspected based on the radiologic findings, and a pancreatoduodenectomy was performed. The removed portion of the pancreas contained a 3.5 × 2 × 1.8 cm well-circumscribed, but not encapsulated white tumor mass with smooth cut surface, cystic component and duct dilatation within the tumor and within the adjacent pancreatic tissue. Based on the histology and immunostaining profile, a diagnosis of the solitary fibrous tumor was made. One week post-operatively, the patient died due to surgical complications. Microscopic and immunohistochemical examinations are necessary for accurate diagnosis of cystic SFT of the pancreas. Because there is limited data regarding the biological behavior of SFT with extra-pleural localization the authors recommend clinical follow-up for SFT treatment if the criteria of malignancy are not met.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

Spasevska¹,

Janevska²,

Janevski

et al. 2016

Prilozi

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“… ACC acinar cell carcinoma, CNS central nervous system, CP central pancreatectomy, DP distal pancreatectomy, EN enucleation, EUS endoscopic ultrasonography, FNA fine-needle aspiration, GIST gastrointestinal stromal tumor, MCN mucinous cystic neoplasm, MP middle pancreatectomy, N.A not available, NEN neuroendocrine neoplasm, Panc pancreas, PD pancreaticoduodenectomy, SFT solitary fibrous tumor, SPDP spleen-preserving distal pancreatectomy, SPN solid pseudopapillary neoplasm a Malignant findings of SFT according to the World Health Organization classification [29] b Information in the postoperative course was retrieved from the report by Baxter et al [14] c The patient had a chest discomfort, which was considered irrelevant to the pancreatic disease…”

Section: Discussionmentioning

confidence: 99%

A rare case of metastatic solitary fibrous tumor of the pancreas manifesting as a cystic neoplasm: a case report

et al. 2019

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Background Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that typically arises from the pleura. Although it may appear in other organs, it rarely develops in the pancreas. We report herein a rare case of metastatic SFT of the pancreas originating from an intracranial tumor and subsequently identified as a cystic neoplasm of the pancreas. Case presentation A 58-year-old woman with a past medical history of brain tumor visited the hospital for further investigation of a cystic tumor in the pancreas tail. Abdominal imaging showed a heterogeneously enhancing mass that was initially suspected as a neuroendocrine neoplasm, solid pseudopapillary neoplasm, or mucinous cystic neoplasm of the pancreas. Distal pancreatectomy was performed without any intraoperative and postoperative complications. Pathological findings confirmed a diagnosis of malignant SFT of the pancreas with hyperproliferative potential. A histopathological review of her brain tumor revealed that the pancreatic tumor was derived from her brain lesion. The patient developed recurrent brain disease 4 years after the pancreatectomy, but no recurrence has been observed in the abdominal cavity. Conclusions SFT should be considered in the differential diagnosis of untypical hypervascular pancreatic mass, particularly in patients with a history of an intrathoracic or intracranial mesenchymal tumor. Immunohistochemical analysis is crucial in detecting this tumor entity. Hyperproliferative status indicates a malignant disease and requires careful postoperative observation.

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“…A solitary fibrous tumour (SFT) is a rare, slow-growing, mesenchymal neoplasm arising from the pleura, which is unrelated to asbestos exposure or cigarette smoking ( 1 ) and was initially described in 1931 ( 2 ). Over the past 80 years, SFTs have been identified in numerous extrapleural locations, including the nasal cavity ( 3 ), breast ( 4 ), stomach ( 5 ), bronchus ( 6 ), head and neck ( 7 ), liver ( 8 ), oesophagus ( 9 ), pelvic ( 10 ), pancreas ( 11 ), prostate ( 12 ), orbit ( 13 ), central nervous system ( 14 ), parotid gland ( 15 ), kidney ( 16 ), lung ( 17 ), sella turcica ( 18 ), heart ( 19 ), conus medullaris ( 20 ), omentum ( 21 ), infratemporal fossa ( 22 ), bladder ( 23 ), soft tissues of the extremities ( 24 ), palatine tonsil ( 25 ), diaphragm ( 26 ), mesentery ( 27 ), lumbar spine ( 28 ), thymus ( 29 ), oral cavity ( 30 ), spermatic cord ( 31 ), thyroid ( 32 ), rectum ( 33 ), salivary glands ( 34 ), retroperitoneum ( 35 ), larynx ( 36 ), trachea ( 37 ), adrenal gland ( 38 ), female genital tract ( 39 ), periosteum of bone ( 40 ), mediastinum ( 41 ) and hypopharynx ( 42 ).…”

Section: Introductionmentioning

confidence: 99%

Primary intrapulmonary solitary fibrous tumours

et al. 2018

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Due to the extreme rarity of primary intrapulmonary solitary fibrous tumours (SFTs), their clinical course, imaging characteristics, diagnosis, treatment and prognosis are poorly understood. The present study therefore assessed the diagnosis and management of primary intrapulmonary SFTs and systematically reviewed previously reported cases in the literature. A total of 5 patients who underwent resection for primary intrapulmonary SFTs were enrolled in the present study and their clinical course, tumour characteristics, management and survival were assessed in this retrospective study. Relevant studies regarding primary intrapulmonary SFTs were searched using PubMed and tumour characteristics, clinicopathologic features, therapeutic strategy and survival outcomes were reviewed. Of the 5 cases, all were males, with a mean age of 57.6 years (range, 37–68 years). All patients were asymptomatic and were identified incidentally on routine computed tomography examination. A total of 3 patients underwent thoracotomy and 2 patients underwent video-assisted thoracoscopic surgery. All tumours were completely resected. Postoperative haemorrhage occurred in 1 patient and he received surgical intervention for haemostasis. The average hospital stay was 15 (4–22) days, and no mortality occurred. The mean length of the postoperative follow-up was 37.6 (1–67) months. One patient was lost to follow-up, and 4 patients were asymptomatic. A total of 19 studies were identified from database searches. They included a total of 45 patients: Twenty-three males and 22 females (mean age, 59.4 years; range, 7–81 years). A total of 12 patients were asymptomatic, and pain and coughing were the major symptoms. Five, one, two, four, and 17 tumours occurred in the right upper lobe, right middle lobe, right lower lobe, left upper lobe and left lower lobe, respectively. A total of 39 patients underwent surgery, 1 patient underwent radiotherapy, and 1 patient underwent radiofrequency ablation. A total of 22 patients were followed up and the mean length of the postoperative follow-up was 48 (1–168) months. One patient was diagnosed with chest wall metastases, and 5 patients succumbed to mortality. To conclude, primary intrapulmonary SFTs are extremely rare and typically identified incidentally. The present findings indicated that the left lower lobe was the most common site location and complete surgical resection is a safe and effective treatment.

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Solitary fibrous tumor of the pancreas

Cited by 21 publications

References 8 publications

Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

A rare case of metastatic solitary fibrous tumor of the pancreas manifesting as a cystic neoplasm: a case report

Primary intrapulmonary solitary fibrous tumours

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