Solitary Fibrous Tumor of the Pancreas: A Case Report and Review of the Literature

Abstract

Pancreas is an extremely rare abdominal localization of the solitary fibrous tumor (SFT). It usually grows asymptomatically for a long time before a diagnosis can be made on the basis of symptoms and/or mechanical complications. Due to the rarity and nonspecific clinical presentation, this entity is diagnostically challenging. We present a 47-year-old man with a history of progressive epigastric pain for the last two weeks, and jaundice, who was admitted to hospital for further investigation. Cystadenocarcinoma was suspected based on the radiologic findings, and a pancreatoduodenectomy was performed. The removed portion of the pancreas contained a 3.5 × 2 × 1.8 cm well-circumscribed, but not encapsulated white tumor mass with smooth cut surface, cystic component and duct dilatation within the tumor and within the adjacent pancreatic tissue. Based on the histology and immunostaining profile, a diagnosis of the solitary fibrous tumor was made. One week post-operatively, the patient died due to surgical complications. Microscopic and immunohistochemical examinations are necessary for accurate diagnosis of cystic SFT of the pancreas. Because there is limited data regarding the biological behavior of SFT with extra-pleural localization the authors recommend clinical follow-up for SFT treatment if the criteria of malignancy are not met.

A rare case of metastatic solitary fibrous tumor of the pancreas manifesting as a cystic neoplasm: a case report

“…According to previous reports, some pancreatic SFTs show heterogenous enhancement similar to the current case [6, 13, 18, 21], presumably depending on the volume of collagen within the tumors [18]. Furthermore, non-enhancing portions can be sometimes found, which mostly derived from cystic degeneration [4, 7, 11, 12, 15] and rarely from tumor necrosis [13] or retention cyst [17]. These findings are, however, not characteristic of SFTs and thus cannot be regarded as distinct imaging features.…”

Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene

“…Although most tumour lesions in the pancreas are epithelial tumours, non‐epithelial, mesenchymal tumours develop in rare cases and there are reports of solitary fibrous tumours (SFTs) 19–34 . An SFT is a fibroblastic tumour characterised by the prominent, branching, thin‐walled, dilated (staghorn) vasculature and NAB2::STAT6 gene rearrangement 35,36 .…”

Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease

“…Usually being a visceral or pleural-based tumor, the solitary fibrous tumor has been reported in the pancreas [9]. The majority of cases in the literature were in females at a mean age of 53 (range: 24 to 77) who were asymptomatic or presented with non-specific abdominal symptoms [12]. These tumors, however, do not usually show calcification [13].…”