Solitary fibrous tumor of the vagina

Abstract

The solitary fibrous tumor (SFT) is a rare tumor that most commonly arises in the pleura. Recent evidence has indicated that this tumor originates from mesenchymal, probably fibroblastic, cells and is not restricted to the pleura. However, its occurrence in the female genital tract is extremely rare. We report a case of primary SFT that originated from the vagina in a 34-year-old female. It was a pedunculated polypoid tumor and occurred at the site of scar tissue, caused by laceration during her last labor 7 years previously. Histologically, the tumor was predominantly composed of a random proliferation of spindle cells, intimately admixed with collagen. Immunohistochemically, the cells were strongly positive for CD34, vimentin and bcl-2, but were negative for S-100 protein, neuron-specific enolase, smooth muscle actin, desmin, CD68, cytokeratins and epithelial membrane antigen. To the best of our knowledge, this is the first reported case of a primary vaginal SFT in the English literature. Our report suggests to include SFT in the differential diagnosis of a spindle cell neoplasm originating from the vagina.

Vaginal Solitary Fibrous Tumor

“…The sites reported thus far include paraovarian [5], uterine cervix [6], paravaginal [7], and vulva [9,10]. To the best of our knowledge, there have only been 2 case reports of primary vaginal SFT in the English literature [2,3].…”

“…The first case, reported by Akiyama et al [2], was a 34-year-old Japanese woman with a spindle cell tumor of the vagina that occurred at the site of scar tissueVthe patient had sustained a lacerated wound during her last labor. An immunohistochemical panel was performed because the differential diagnosis of spindle cell lesions of the vagina is quite extensive ( Table 1).…”

“…To the best of our knowledge, there have been only 2 previous case reports of a primary vaginal SFT [2,3] in the recent English literature. We report a third case.…”

Solitary fibrous tumor of the vagina with potentially malignant features: a case report and review of the literature

“…To the best of our knowledge, there have been only 4 previous case reports of a primary vaginal SFT in the English literature (3)(4)(5)(6). In this article we describe a fifth case that recurred 4 years after the first excision.…”

Solitary fibrous tumor in the thigh: review of the literature

“…Despite they are seldom located in extrapleural soft tissue this tumor has been reported in a variety of extraserosal sites (Ramdial and Madaree 2001). By reviewing the literature following locations are described: lumbar extradural (Donnellan et al 2000), intrameningeal (Nawashiro et al 2000;Kawamura et al 2004), in cervical spine (Obara et al 2003;Bohinski et al 2004), in the deep soft tissue of the neck (Goh et al 2002;Bachmeyer et al 2004), in orbital space (Ahn et al 2001;O'Donovan et al 2002;Schellini et al 2003), in pelvic space (Ishikawa et al 2004), retroperitoneal (Nagasako et al 2004), vaginal (Akiyama et al 2000), in the thyroid gland (Parwani et al 2003;Babouk 2004), in mammary gland (Falconieri et al 2004), in prostate (Ishii et al 2004), in nasal mucosa (Munks 2003), in the liver (Neeff et al 2004), in renal pelvis (Yazaki et al 2001;Magro et al 2002), and in extremities (Akisue et al 2003). All of these tumors are diagnosed and categorized by histology and immunohistochemical patterns.…”