Solitary Fibrous Tumor of the Liver: Retrospective Study of Reported Cases

Abstract

A solitary fibrous liver tumor is a rare disease that is difficult to diagnose. Radiological findings are not specific and cannot confirm benignity or malignancy. Immunohistologically, CD 34, Vimentin, and Desmin should be used as markers to precisely diagnose solitary fibrous tumors. In most cases, there is low cellularity with no cellular atypia or necrosis, making this a benign lesion. Occasionally, a large size, high mitotic rate, cellular pleomorphism and atypia, and necrosis are interpreted as features suggestive of an increase malignant potential. The outcome of solitary fibrous tumor mostly is related to resectability, although correlated with neither pathological grade nor tumor size. Thus, total surgical resection of the neoplasm is most commonly proposed. Physicians should be alerted that solitary fibrous tumor of the liver can be malignant and can metastasize.

Malignant metastasizing solitary fibrous tumors of the liver: a report of three cases

“…Only 42 cases of primitive liver SFT have been described, and only 4 of those were classified as malignant [1]. Although there are no close correlations between morphology and malignant behavior, large size (more than 5 or 10 cm), sessile lesions, infiltrative margins, hypercellularity, nuclear pleomorphism, cytologic atypia, necrosis or hemorrhage and an increased mitotic index (more than 4 mitoses in 10 HPFs) have been described in malignant SFTs [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

“…[28] The liver is a rare primary site for SFTs with less than 50 cases reported in the English literature. [7][8][9][10][11][12][13][14][15][16][17][18][19] Patient characteristics associated with hepatic SFTs include a mean age of 55 years at presentation, female sex predilection (2:1), and an average tumor size of 17 cm. [7] Although the vast majority of hepatic SFTs behave in a benign fashion, their unpredictable behavior must be emphasized.…”

“…[2][3][4][5][6] The liver is a rare primary site for SFTs with less than 50 cases reported in the English literature. [7][8][9][10][11][12][13][14][15][16][17] Although most cases of SFTs are benign, there have been cases of SFTs with malignant features and metastasis. [18,19] Both clinical and radiographic features are not entirely specific and cannot exclude malignancy.…”

Tumor fibroso solitario de la pleura

“…El tumor fibroso solitario se ha informado en múltiples localizaciones de la economía corporal [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] . Estas lesiones tienen las mismas características citogenéticas, morfológicas e inmunohistoquímicas de las observadas en esta neoplasia en la pleura, por lo cual se ha establecido que se trata de la misma lesión 7 .…”

“…Se he reportado en membranas serosas como el peritoneo 40 , ya sea parietal, visceral, retroperitoneo, mesenterio, omento, pared abdominal y sacos herniarios 41 ; también se ha informado en el pericardio, en el cual existen a la fecha 5 casos reportados 42,43 . Otras localizaciones incluyen: meninges, con aproximadamente 30 casos reportados 44 ; cordón espinal, con 12 casos; cavidad oral, con 50 casos 45 ; glándula mamaria, con 50 casos 46 ; tracto gastrointestinal, en el cual se debe hacer su distinción con el tumor estromal gastrointestinal, mediante inmunohistoquímica 47 ; piel, con 10 casos reportados 48 ; riñón, con 20 casos reportados 49 ; tracto genital femenino 50 , y otras 32 localizaciones como órbi-ta, cavidad nasal 51 , espacio pélvico, hígado 52 , mediastino, próstata, glándulas salivales 53 , vías respiratorias superiores, páncreas 54 , corazón, conjuntiva, tiroides 55 , vejiga, amígdalas, vaina carotídea, testículo, entre otros.…”