Solitary mastocytoma with positive Darier′s sign

Nair, B. Y. L.; Sonthalia, Sidharth; Aggarwal, Ishad

doi:10.4103/2229-5178.178091

Cited by 6 publications

(4 citation statements)

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“…Неліковані вагініти спричинюють розвиток хронічних захворювань органів малого тазу (ендометрит, сальпінгіт та інше). Також вагініти підвищують ризик захворювання на інфекції, що передаються статевим шляхом (гонорея, хламідіоз, ВІЛ-інфекція та інше), та є ко-фактором виникнення передракових уражень шийки матки на фоні інфікування вірусом папіломи людини [4,5,6,7].…”

Section: вступunclassified

The effectiveness of complex therapy in the treatment of nonspecific vaginitis in women of reproductive age

Ryazanova

Резніченко

2022

Modern Medical Technology

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Objective. One of the most common gynecological pathologies among women of reproductive age is non-specific vaginitis. Bacterial vaginosis and aerobic vaginitis cause many obstetric and gynecological complications, and disease recurrence remains high. The aim of the study is to assess the effectiveness of complex therapy in the treatment of non-specific vaginitis in women of reproductive age. Materials and Methods. 160 women (100%) were examined, which were divided into 2 clinical groups with subgroups: the main group - 94 (58.8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41.2 %) patients with nonspecific vaginitis, who received treatment according to known protocols. Research methods: general (collection of complaints and anamnesis, gynecological examination, assessment of microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), laboratory (determination levels of follicle-stimulating, luteinizing hormones, prolactin, estradiol, adrenaline, noradrenaline, cortisol, magnesium in the blood), statistical. Results. Treatment of non-specific vaginitis according to complex schemes in the main group showed a significant decrease in the average follicle-stimulating hormone indicators – by 2.7 times, luteinizing hormone – by 2.6 times, prolactin – by 1.3 times (р<0,05) compares to the indicators before treatment. The estradiol level in the main group probably increased 1.3 times (р<0,05). The magnesium level also increased by an average of 1.4 times (р<0,05). Complex therapy in the main group significantly reduced the adrenaline levels by an average of 1.6 times, noradrenaline by 2.4 times, and cortisol by 1.8 times compared to the values before treatment (р<0,05). The proposed complex schemes are likely to improve the clinical effectiveness of drug treatment of non-specific vaginitis in the near and distant periods, which is accompanied by faster disappearance of complaints and normalization of the local condition during the gynecological examination (p<0,05), restoration of the vaginal microflora (p<0,05), a decrease frequency of recurrence in the main group of patients (c2=4,32; p<0,05). Conclusions. It is appropriate to use complex treatment of bacterial vaginosis and aerobic vaginitis in women of reproductive age.

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Section: вступunclassified

The effectiveness of complex therapy in the treatment of nonspecific vaginitis in women of reproductive age

Ryazanova

Резніченко

2022

Modern Medical Technology

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“…3 ) [8, 9, 13, 24-26]. The lesion often has a peau d'orange (pebbly, orange peel-like) appearance and a leathery or rubbery consistency [9, 12, 21, 26, 27]. The lesional margins can be indistinct or sharp [2].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Other differential diagnoses include juvenile xanthogranuloma, xanthoma, postinflammatory hyperpigmentation, epidermolysis bullosa simplex, allergic contact dermatitis, café-au-lait macule, bruise, melanocytic nevus, Spitz nevus, amelanotic melanoma, neurofibroma, granuloma annulare, granuloma faciale, hemangioma, nodular scabies, arthropod bite, drug-related eruption, histiocytosis, leukemia cutis, chronic urticaria, herpes simplex, bullous impetigo, hidrocystoma, and linear IgA bullous dermatosis [15, 21, 24-27].…”

Section: Differential Diagnosismentioning

confidence: 99%

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Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management

Leung

Lam

Leong

2019

CPR

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Background: The diagnosis of solitary cutaneous mastocytoma is mainly clinical, based on lesion morphology, the presence of a positive Darier sign, and the absence of systemic involve-ment. Knowledge of this condition is important so that an accurate diagnosis can be made.Objective: To familiarize physicians with the clinical manifestations, diagnosis, evaluation, and man-agement of a solitary cutaneous mastocytoma.Methods: A PubMed search was completed in Clinical Queries using the key term “solitary cutane-ous mastocytoma”. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Only papers published in English language were included. The information retrieved from the above search was used in the compilation of the present article.Results: Typically, a solitary cutaneous mastocytoma presents as an indurated, erythematous, yellow-brown or reddish-brown macule, papule, plaque or nodule, usually measuring up to 5 cm in diameter. The lesion often has a peau d'orange appearance and a leathery or rubbery consistency. A solitary cu-taneous mastocytoma may urticate spontaneously or when stroked or rubbed (Darier sign). Organo-megaly and lymphadenopathy are characteristically absent. The majority of patients with skin lesions that erupt within the first two years of life have spontaneous resolution of the lesions before puberty. Treatment is mainly symptomatic. Reassurance and avoidance of triggering factors suffice in most cases.Conclusion: The diagnosis is mainly clinical, based on the morphology of the lesion, the presence of a positive Darier sign, and the absence of systemic involvement. A skin biopsy is usually not neces-sary unless the diagnosis is in doubt.

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Solitary Cutaneous Mastocytoma in an Adult Diagnosed on Cytology: A Rare Case Report

Suneja,

Nambiar,

Tanveer

et al. 2024

Diagnostic Cytopathology

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Mastocytosis is characterized by the proliferation of neoplastic mast cells in various organs, which can have either cutaneous or systemic presentation. Solitary cutaneous mastocytomas are most commonly seen in the pediatric age group but rarely present in adults. Histopathology of cutaneous mastocytoma is well described in the literature but only a few studies are available describing the cytomorphological features. We present a case of a 19‐year‐old female who presented with a 6‐month history of a right supraclavicular single, 0.5 × 0.5 cm, well‐defined, reddish‐brown round nodule. The fine needle aspiration cytology (FNAC) smears were highly cellular showing monomorphic cells, predominantly dispersed singly and occasionally in small clusters. The cells were round to oval, with moderate cytoplasm containing coarse metachromatic granules. Toluidine blue stain and CD117 immunocytochemical stain confirmed the presence of mast cell granules. Based on the cytomorphology, staining, clinical history, and examination, a diagnosis of solitary cutaneous mastocytoma was rendered. FNAC plays a pivotal role in diagnosing mast cell tumors and even obviates the need for tissue biopsy in selected cases.

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Solitary mastocytoma with positive Darier′s sign

Cited by 6 publications

References 4 publications

The effectiveness of complex therapy in the treatment of nonspecific vaginitis in women of reproductive age

The effectiveness of complex therapy in the treatment of nonspecific vaginitis in women of reproductive age

Childhood Solitary Cutaneous Mastocytoma: Clinical Manifestations, Diagnosis, Evaluation, and Management

Solitary Cutaneous Mastocytoma in an Adult Diagnosed on Cytology: A Rare Case Report

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