Solitary neurofibroma in the male breast

Abstract

To our knowledge this is only the second case of a neurofibroma in a male breast in the English literature and the first report to include the mammographic findings.

Solitary neurofibroma of the breast

“…They are relatively common in both sexes and can occur at any age (2). They are slow-growing, and the majority are painless.…”

“…Most neurofibromas occur as solitary lesions in the dermis or subcutis, are distributed evenly over the body surface, and occur very rarely in breast tissue (3, 4). Only a few cases of breast neurofibromas have been reported, both in men and women—excluding neurofibromas in the presence of neurofibromatosis (von Recklinghausen’s disease), which is considered a separate disease process (1, 2, 7, 8, 9). …”

“…Grossly, neurofibromas are white-gray, soft, and well circumscribed but not encapsulated (2, 5). They vary in shape and in size, most measuring between 1 cm and 2 cm (6).…”

“…Microscopically, neurofibromas are formed by a combined proliferation of all the elements of a peripheral nerve, Schwann cells being the most predominant (5). Most contain interlacing bundles of cells with elongated, wavy, and dark-staining nuclei with pointed ends and slender cytoplasmic processes (2, 3, 5). These cells are arranged closely and separated by mucoid material.…”

Manifestations cutanées du cancer du sein chez l’homme

“…Toute pathologie cutanée pourrait se localiser sur la peau couvrant la glande mammaire. Des affections dermatologiques peuvent simuler un cancer du sein posant ainsi un problème de diagnostic différentiel : pilomatricome, fibrome cutané, neurofibrome, kyste épidermoïde, lipome, hémangiome souscutané, tumeur annexielle bénigne ou maligne, myélome multiple, plasmocytome, léiomyome, métastase mammaire de cancer de prostate [19][20][21][22][23][24][25][26][27][28]. Des cas de panniculite lupique ou tuberculeuse et de mastite granulomateuse avec ou sans modification cutanée, peuvent aussi simuler un cancer du sein d'autant plus qu'elles peuvent s'accompagner d'une rétraction du mamelon et d'adénopathies axillaires [28][29][30][31].…”