Solitary neurofibroma of the breast

Thompson, Sherry; Kaplan, Steven N.; Poppiti, Robert; Collado-Mesa, Fernando; Rabinovich, Katrina

doi:10.2484/rcr.v7i4.462

Cited by 16 publications

(15 citation statements)

References 5 publications

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“…As the growth of neuro broma is slow, and can occur at any age, has no sexual preference, and usually has no pain, numbness or other discomfort symptoms (15), its diagnosis is mainly depending on the result of imaging and microscopy. The differential diagnosis includes nodular fasciitis, myxoma, neuro brosarcoma and adult rhabdomyoma, especially schwannoma (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the MRI, which is the most sensitive imaging method for soft tissue, manifests neuro broma may similar to those of schwannoma. They usually show low or equal signal compared with muscle on T 1 -weighted image(T1WI), high signal on T 2 -weighted image(T2WI), and can change with the enhancement of contrast agent, especially when the tumor has mucoid mechanism, it can show no or slight enhancement (8,15). It is worth noting that compared with schwannoma, neuro broma often lacks complete capsule, which may help us to distinguish common cases by MRI images (6).…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, neuro broma is rich in mucoid tissue (Antoni B area), while schwannoma has a compact stroma (Antoni A area) (8). In addition, although both of them are composed of fusiform nerve sheath cells, the nuclei of neuro broma are slender and wavy, while the nuclei of schwannoma are oblong and arranged closely and parallel to each other in palisade or incomplete voracies (Verocay bodies) (4,15). Immunohistochemical results also provide the basis for differentiation, which is re ected in the uneven staining of S-100 protein, only local immune response to epithelial membrane antigen (EMA), and strong CD34 positive in neuro broma, while schwannoma cells showed more intense and uniform staining of S-100 protein, and the capsule stained EMA (2,4).…”

Section: Discussionmentioning

confidence: 99%

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A Solitary Giant Neurofibroma of Inguinal Region—A Case Report

Zhou

Lü²

2020

Preprint

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Abstract Background:Neurofibroma is a rare nerve sheath tumorofneuroectodermal origin, especially the huge and isolated neurofibroma located in the inguinal region. To our knowledge, no such case has previously been reported.Case presentation:We report a case of 34-year-old male patient with a 4-year history of progressive enlargement of the medial root mass in his left thigh with sitting and standing disorders along with pain. The tumor was completely removed by operation, and pathological diagnosisshowed neurofibroma. There was no obvious neurologic defect after surgery, and no recurrence tendency was found in the follow-up of 2years.Conclusions:For a large solitary mass with slow growth and no malignant clinical manifestations for a long time, clinicians can not rule out the hypothetical diagnosis of neurofibroma, even though its growth site is very rare, such as this case of a huge tumor located in the groin. For neurogenic tumors, early operation should be performed, and the prognosis of patients after tumor resection isexcellent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Solitary Giant Neurofibroma of Inguinal Region—A Case Report

Zhou

Lü²

2020

Preprint

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“…Neurofibroma soliter dapat tidak berkaitan dengan neurofibroma pada neurofibromatosis tipe 1 (penyakit von Recklinghausen). 2,3,4 Neurofibroma dan schwannomas dilaporkan mewakili sekitar 10% sampai 12% dari semua neoplasma jinak jaringan lunak. 5 Belum ada laporan perubahan cutaneus neurofibroma menjadi lesi yang ganas.…”

Section: Pendahuluanunclassified

Terapi Eksisi Pada Neurofibroma

Yulian

Widiatmoko

Retnani

2018

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Neurofibroma dapat tampak sebagai nodul soliter atau dapat merupakan bagian dari neurofibromatosis atau penyakit Von Recklinghausen. Neurofibroma sering dikeluhkan karena alasan kosmetik atau adanya rasa nyeri terbakar dan gatal. Seorang laki-laki 56 tahun mengeluh benjolan di dada sebelah kiri sejak 43 tahun yang lalu. Benjolan awalnya muncul seperti jerawat yang bertambah besar secara lambat dan kadang terasa nyeri jika tersenggol baju sejak beberapa bulan terakhir. Riwayat keluarga ibu dan anak pasien terdapat benjolan yang sama. Pasien memiiki riwayat penyakit epilepsi. Pada pemeriksaan dermatologis didapatkan nodul sewarna kulit, bentuk bulat, batas tegas, diameter 3 mm-7,5 mm pada perabaan didapatkan konsistensi kenyal, mudah bergerak dan tidak terfiksasi dengan jaringan dibawahnya. Tidak didapatkan nodul lisch, freckles pada ketiak maupun tanda cafe-au lait. Pada pasien dilakukan tindakan bedah eksisi atas indikasi rasa tidak nyaman pada pasien. Pemeriksaan histopatologi jaringan hasil eksisi dengan pewarnaan HE dan imunohistokimia S100 menunjukkan gambaran sesuai dengan suatu neurofibroma. Neurofibroma dapat tumbuh secara invasif. Pada lesi yang mengganggu secara kosmetik sering dilakukan terapi pembedahan. Modalitas terapi pembedahan untuk menghilangkan neurofibroma bergantung pada tipe, lokasi, ukuran tumor. Modalitas terapi dapat dipilih bedah eksisi, bedah listrik maupun reseksi. Pada kasus ini dipilih modalitas terapi bedah eksisi pada neurofibroma. Hasil terapi setelah satu bulan menunjukkan hasil yang baik. Tidak tampak adanya gambaran skar hipertrofik Kata kunci: eksisi, neurofibroma, imunohistokimia s100.

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“…Intramammary peripheral nerve sheath tumorsincluding NF and schwannomas-are uncommon. 1,2 Intramammary NF typically occur as an asymptomatic and solitary lesion, 3 although multiple mainly cutaneous-based ones can ensue in neurofibromatosis type 1. 4 The macroscopic and microscopic appearances of NF are largely similar in all locations, although its myxoid variant has been described in the breast as elsewhere.…”

mentioning

confidence: 99%