Solitary Neurofibroma of the Zygoma: Three-Dimensional Virtual Resection and Patient-Specific Polyetheretherketone Implant Reconstruction

Shi, Huan; Yin, Xuelai; Hu, Yongjie

doi:10.1097/scs.0000000000008526

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…We identified 32 articles reporting data on the use of PEEK PSIs for reconstruction or aesthetic augmentation of the facial skeleton in 194 patients (Table 1, Supplementary Figure S1) (13-23, [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][41][42][43][44].…”

Section: Resultsmentioning

confidence: 99%

Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?

Kauke-Navarro,

Knoedler,

Knoedler

et al. 2024

Front. Surg.

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Facial implantology, a crucial facet of plastic and reconstructive surgery, focuses on optimizing implant materials for facial augmentation and reconstruction. This manuscript explores the use of Polyetheretherketone (PEEK) implants in craniofacial surgery, highlighting the challenges and advancements in this field. While PEEK offers mechanical resilience, durability, and compatibility with imaging modalities, its biologically inert nature hinders integration with the host tissue, which may lead to complications. In this systematic review, our aim was to assess the current state of knowledge regarding the clinical evaluation of Polyetheretherketone (PEEK) implants in facial implantology, with a focus on craniofacial augmentation and reconstruction in human studies. Additionally, we explore and discuss surface and structural modifications that may enhance bioreactivity and reduce complications in PEEK implants. A systematic review identified 32 articles detailing the use of PEEK Patient-Specific Implants (PSIs) in 194 patients for both reconstructive and aesthetic purposes. Complications, including infections and implant failures, were reported in 18% of cases, suggesting the need for improved implant materials. The discussion delves into the limitations of PEEK, prompting the exploration of surface and structural modifications to enhance its bioreactivity. Strategies, such as hydroxyapatite coating, titanium coating, and porous structures show promise in improving osseointegration and reducing complications. However, the literature review did not reveal reports of coated or modified PEEK in facial reconstructive or aesthetic surgery. In conclusion, although PEEK implants have been successfully used in craniofacial reconstruction, their biological inertness poses challenges. Surface modifications, particularly hydroxyapatite coatings, provide opportunities to promote osseointegration. Future research should focus on prospective long-term studies, especially in craniofacial surgery, to investigate the stability of uncoated PEEK implants and the potential benefits of surface modifications in clinical applications. Patient-specific PEEK implants hold promise for achieving durable craniofacial reconstruction and augmentation.

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Section: Resultsmentioning

confidence: 99%

Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?

Kauke-Navarro,

Knoedler,

Knoedler

et al. 2024

Front. Surg.

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“…The maxilla is an unusual site for these neoplasms. Since Toth et al first described solitary intraosseous neurofibromas of the maxilla in 1975, only a few cases have been reported in English literature [2][3][4][5][6][7][8]. Herein, we report a rare case of an isolated intraosseous neurofibroma of the hard palate in the absence of syndromic neurofibromatosis, which was fortuitously discovered during systematic clinical examination.…”

Section: Introductionmentioning

confidence: 81%

“…Neurofibromas most commonly occur on the skin, and the frequency of all neurofibromas occurring in the head and neck region are reported to be approximately 25%. Solitary presentation in the oral cavity or as part of a systemic syndrome was detected in 6.5% of cases [ 2 , 5 ]. Intraoral isolated neurofibromas are uncommon; they can be intraosseous, although most are extraosseous.…”

Section: Introductionmentioning

confidence: 99%

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

Guo,

Wu,

Liang

et al. 2024

BMC Oral Health

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Background Neurofibroma is a common benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Nine months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare locations of neurofibromas, such as solitary intraosseous neurofibromas in the maxilla, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

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“…The clinical behavior of neuro bromas is characterized by a benign course with a low frequency of recurrence after surgical excision, primarily because of the absence of a complete capsule [2,[4][5][6]. The local recurrence rate of this condition may be lower due to the appearance of a complete capsule.…”

Section: Discussionmentioning

confidence: 99%

“…Neuro bromas most commonly occur on the skin, and the frequency of all neuro bromas occurring in the head and neck region was reported to be approximately 25%. Solitary presentation in the oral cavity or as part of a systemic syndrome was detected in 6.5% of cases [2,5]. Intraoral isolated neuro bromas are uncommon; they can be intraosseous, whole most are extraosseous.…”

Section: Introductionmentioning

confidence: 99%

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

Guo,

Wu,

Liang

et al. 2024

Preprint

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Background Neurofibroma is a benign tumor of neuronal origin that can occur as a solitary tumor or as a component of the generalized syndrome of neurofibromatosis. Neurofibromas are primarily located in the subcutaneous soft tissues and commonly involve extra-oral sites. Solitary intraosseous neurofibromas of the oral cavity are infrequent, with occurrences in the maxilla being exceedingly rare. Case presentation: A 22-year-old male patient presented with an asymptomatic mass in the maxilla. Cone-beam computed tomography revealed a round, well-outlined, radiolucent lesion with expansive growth. The neoplasm with the complete capsule was completely removed and confirmed as a neurofibroma based on histopathological and immunohistochemical findings. The reported cases of solitary intraosseous neurofibromas located in the maxilla published in the English literature were compiled to assist in the diagnosis of solitary intraosseous neurofibromas of the maxilla. Four months after the surgery, there were no signs of tumor recurrence or malignant transformation. Conclusions This report emphasizes that rare neoplasms, such as solitary intraosseous neurofibromas, typically demonstrate nonspecific clinical and radiological features. Clinicians should consider solitary intraosseous neurofibromas as possible differential diagnoses and recognize the histopathological and immunohistochemical features to confirm the correct diagnosis. A longer follow-up period is required because of the potential for local recurrence and malignant transformation of these tumors.

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Solitary Neurofibroma of the Zygoma: Three-Dimensional Virtual Resection and Patient-Specific Polyetheretherketone Implant Reconstruction

Cited by 6 publications

References 10 publications

Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?

Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?

Solitary intraosseous neurofibroma of the oral cavity: rare localization in the maxilla

Solitary Intraosseous Neurofibroma of the Hard Palate: A Case Report and Literature Review

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