Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma

Dimopoulos, Meletios A.; Kiamouris, Christos; Moulopoulos, Lia A.

doi:10.1016/s0889-8588(05)70124-6

Cited by 197 publications

(156 citation statements)

References 51 publications

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“…Solitary plasmacytoma (SP), accounting for 5% to 10% of all plasma cell neoplasms (Dimopoulos et al, 2002;Ozsahin et al, 2006), is a rare malignancy defined as a proliferation of monoclonal plasma cells without any systematic involvement. Two subsets are categorized in terms of the location--solitary plasmacytoma of bone (SBP) and extramedullary plasmacytoma (EMP).…”

Section: Introductionmentioning

confidence: 99%

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Radiotherapy Alone is Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma

Li¹,

Niu²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP), but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities in the management of SP. Materials and Methods: Data from 38 consecutive patients with solitary plasmacytoma, including 16 with bone plasmacytoma and 22 with extramedullary plasmacytoma, were retrospectively reviewed. 15 patients received radiotherapy alone; 11 received surgery alone, and 12 received both. The median radiation dose was 50Gy. All operations were performed as radical resections. Local progression-free survival (LPFS), multiple myeloma-free survival (MMFS), progression-free survival (PFS) and overall survival (OS) were calculated and outcomes of different therapies were compared. Results: The median follow-up time was 55 months. 5-year LPFS, MMFS, PFS and OS were 87.0%, 80.9%, 69.8% and 87.4%, respectively. Univariate analysis revealed, compared with surgery alone, radiotherapy alone was associated with significantly higher 5-year LPFS (100% vs 69.3%, p=0.016), MMFS (100% vs 51.4%, p=0.006), PFS (100% vs 33.7%, p=0.0004) and OS (100% vs 70%, p=0.041). Conclusions: Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study.

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Section: Introductionmentioning

confidence: 99%

“…Two subsets are categorized in terms of the location--solitary plasmacytoma of bone (SBP) and extramedullary plasmacytoma (EMP). SBP usually locates in the axial skeleton while EMP occurs in soft tissues, mainly in the head and neck area (Dimopoulos et al, 2002). SP responds well to local treatment.…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy Alone is Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma

Li¹,

Niu²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Extramedullary plasmacytoma has more favorable prognosis compared to the plasmacytoma of the bone [13]. Treatment options include surgery and/or radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment options include surgery and/or radiation therapy. Extramedullary plasmacytoma respond well to radiation therapy [2,6,13]. Data from literature shows that around 60 % of patients with plasmacytoma of upper aerodigestive tract had no recurrence or progression to multiple myeloma whereas 22 % cases had recurrence and 16 % showed progression to multiple myeloma [2,3,14].…”

Section: Discussionmentioning

confidence: 99%

Extramedullary Plasmacytoma of the Trachea

Saxena

Nair

Jacob

et al. 2013

Head and Neck Pathol

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Extramedullary plasmacytomas are plasma cell tumors that occur outside the bone marrow. They constitute around 4 % of all plasma cell neoplasms. The most common site of extramedullary plasmacytoma is the upper aerodigestive tract-nasal cavity, paranasal sinuses and oronasopharynx. We are presenting a case of extramedullary plasmacytoma of the trachea. Trachea is an extremely rare site of plasmacytoma. When extraosseous plasmacytoma occur in uncommon sites, the distinction from B cell lymphomas showing extensive plasmacytic differentiation can be difficult and diagnostically challenging.

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“…An evaluation for multiple myeloma is needed to establish the diagnosis of an isolated EMP or SPB. 1,2,3 A plasmacytoma involving the skull base is unusual, and a limited number have been reported. We present the clinical history and radiographic findings of four patients with a plasma cell tumor of the skull base and review the rates of progression of skull base primary sites to multiple myeloma.…”

mentioning

confidence: 99%