Solitary spinal cord metastasis of Wilms' tumor

Chang, W T; Chen, Hou-Chuan; Peng, Hai-Chyi; Yang, Dar-Yu; Chang, Cecil Guang-Shiung

doi:10.1016/0022-3468(90)90572-q

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…As described in these cases and other pediatric oncology patients with spinal canal involvement, back pain in general is the most common sign (go%), followed by motor weakness (67%), sphincter dysfunction (57%), and sensory abnormalities (14%) [1,6,7]. The median time from onset of symptoms to diagnosis of spinal canal involvement is reported to be 2 weeks [ 11, although this period can be as long as 8 months [3].…”

Section: Case Reportmentioning

confidence: 97%

“…Spinal cord metastasis is rarely reported in the literature [3,5-91. To date, 15 cases of Wilms' tumor with spinal canal involvement have been reported in the English language literature (Table I) [3,[5][6][7][8][9]11,13,14]. As described in these cases and other pediatric oncology patients with spinal canal involvement, back pain in general is the most common sign (go%), followed by motor weakness (67%), sphincter dysfunction (57%), and sensory abnormalities (14%) [1,6,7]. The median time from onset of symptoms to diagnosis of spinal canal involvement is reported to be 2 weeks [ 11, although this period can be as long as 8 months [3].…”

Section: Case Reportmentioning

confidence: 99%

“…Among the previously reported cases, only patients 7, 10, and 14 (Table I) had abnormal plain spine radiological findings. Several mechanisms have been suggested in the pathogenesis of spinal cord metastasis, including direct extension from a paravertebral tumor mass, hematogenous spreading through collateral circulation of the paravertebral venous plexus, lymphatic spreading through the intervertebral foramen, or spreading along the perineurium of the spinal nerves [6]. In adults, the metastasis most often invades the epidural space from a vertebral site, whereas in children the epidural space seems to be invaded most probably by direct…”

Section: Case Reportmentioning

confidence: 99%

“…Bever et a]. Considering the treatment of metastatic spinal canal Wilms' tumor, decompressive laminectomy, excision of tumor, adjuvant radiotherapy (2,0OO-3,000 rads over the involved spine for possible residual tumor cells in the tumor bed) and mostly the three drug regimen (Act-D, VCR, and ADM and/or cyclophosphamide [CP]) are recommended [5,6]. In most of the previously reported cases epidural metastases occurred while the patients were in remission.…”

Section: )mentioning

confidence: 99%

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Epidural metastasis in Wilms' tumor: A case report and review of the literature

Darendeliler

Ayan

Kebudi

et al. 1994

Med. Pediatr. Oncol.

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Spinal canal involvement is not a common pattern of metastasis in Wilms' tumor. Although early detection and treatment can achieve improvement of neurological deficit, mortality remains high. We present a 5-year-old girl who had an epidural metastasis while she was receiving chemotherapy for stage IV Wilms' tumor. Within 2 months following laminectomy, total removal of tumor, radiotherapy, and adjuvant chemotherapy some of the neurological signs improved.

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Section: Case Reportmentioning

confidence: 97%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

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Epidural metastasis in Wilms' tumor: A case report and review of the literature

Darendeliler

Ayan

Kebudi

et al. 1994

Med. Pediatr. Oncol.

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“…(3)(4)(5)(6)(7)(9)(10)(11)(12)(13)(14). Additionally, Arrotegui et al(15) reported a further case of Wilms' tumor associated with spinal cord involvement.…”

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confidence: 99%

A case of Wilms' tumor with spinal cord involvement

et al. 2015

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Intraspinal Wilms' tumor metastases

Cohn

Hamre

Kletzel

et al. 1994

Cancer

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Background. Intraspinal Wilms' tumor metastasis is rare, and is associated with a high mortality rate. Methods. The authors reviewed the clinical course of two patients with Wilms' tumor in whom extradural metastasis developed. In addition, a review of the literature and of patients entered in the National Wilms' Tumor Studies was performed to determine the clinical presentation, treatment, and outcome of other patients with Wilms' tumor with intraspinal metastases. Results. Both of the patients initially had abdominal pain without neurologic deficits. Despite therapy, paraplegia secondary to cord compression from recurrent epidural metastases developed in one patient, although a third remission has been achieved with further chemotherapy. The second patient remains in disease‐free remission 25+ months after surgical resection of the extradural spinal tumor, adjuvant chemotherapy and radiation therapy, and autologous bone marrow transplantation. Review of the literature and of the patients entered in the National Wilms' Tumor Studies revealed an additional 27 patients with Wilms' tumor with this pattern of metastasis. Only four were disease‐free at the time of this report. Conclusions. The authors' experience stresses the importance of early recognition and treatment of this complication of Wilms' tumor and demonstrates that intensive multimodality therapy can result in long‐term disease‐free remission.

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Solitary spinal cord metastasis of Wilms' tumor

Cited by 8 publications

References 8 publications

Epidural metastasis in Wilms' tumor: A case report and review of the literature

Epidural metastasis in Wilms' tumor: A case report and review of the literature

A case of Wilms' tumor with spinal cord involvement

Intraspinal Wilms' tumor metastases

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