Solitary spinal metastasis of Hürthle cell thyroid carcinoma

Sciubba, Daniel M.; Petteys, Rory J.; Kang, Seung-Min; Than, Khoi D.; Gokaslan, Ziya L.; Gallia, Gary L.; Wolinsky, Jean Paul

doi:10.1016/j.jocn.2009.09.039

Cited by 8 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They derive from follicular cells. Medullary carcinoma, in contrast, constitutes 5–10% of thyroid cancers [5,11,12]. …”

Section: Introductionmentioning

confidence: 99%

“…It is too, characterised by indolence and localised spread, as well as metastasis to different sites. It has a poor prognosis but can be treated if found before distant spread [3,5,12,13]. …”

Section: Introductionmentioning

confidence: 99%

“…Males are more likely to be afflicted; this is thought to be reflective of the higher prevalence of lung cancer in this group [12] and the higher prevalence of prostate cancer relative to breast cancer in females [25]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spinal metastasis in thyroid cancer

et al. 2012

View full text Add to dashboard Cite

BackgroundThyroid carcinoma generally responds well to treatment and spinal metastasis is an uncommon feature. Many studies have looked at the management of spinal metastasis and proposed treatments, plans and algorithms. These range from well-established methods to potentially novel alternatives including bisphosphonates and vascular endothelial growth factor (VEGF) therapy, amongst others.The purposes of this systematic review of the literature are twofold. Firstly we sought to analyse the proposed management options in the literature. Then, secondly, we endeavoured to make recommendations that might improve the prognosis of patients with spinal metastasis from thyroid carcinomas.MethodsWe conducted an extensive electronic literature review regarding the management of spinal metastasis of thyroid cancer.ResultsWe found that there is a tangible lack of studies specifically analysing the management of spinal metastasis in thyroid cancer. Our results show that there are palliative and curative options in the management of spinal metastasis, in the forms of radioiodine ablation, surgery, selective embolisation, bisphosphonates and more recently the VEGF receptor targets.ConclusionsThe management of spinal metastasis from thyroid cancer should be multi-disciplinary. There is an absence; it seems, of a definitive protocol for treatment. Research shows increased survival with 131I avidity and complete bone metastasis resection. Early detection and treatment therefore are crucial. Studies suggest in those patients below the age of 45 years that treatment should be aggressive, and aim for cure. In those patients in whom curative treatment is not an option, palliative treatments are available.

show abstract

“…They derive from follicular cells. Medullary carcinoma, in contrast, constitutes 5–10% of thyroid cancers [5,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spinal metastasis in thyroid cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

“…2 Hürthle cell carcinoma is a rare variant of differentiated thyroid cancer characterized by solid tumor nests and microfollicle formation, sometimes with abundant colloid production and strong immunocytochemical reactivity for thyroglobulin. 3,4 Even in the presence of metastases, patients with Hürthle cell carcinoma usually have a relatively good prognosis, being considered the most favorable histologic subtype for survival. 3 Few other reports disclosed Hürthle cell carcinoma as spinal metastasis, and none with sacral involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Hürthle cell carcinoma is a rare variant of differentiated thyroid cancer and occasionally generates distant metastases. [2][3][4] There are few reports of Hürthle cell carcinoma metastases to the vertebral column and none with sacral involvement. [2][3][4] We report a unique case of Hürthle cell carcinoma metastasis to sacral spine presenting with low back pain.…”

Section: Introductionmentioning

confidence: 99%

Low Back Pain as the First Presentation of Hürthle Cell Carcinoma of Thyroid

et al. 2015

View full text Add to dashboard Cite

H?rthle cell carcinoma is a rare variant of differentiated thyroid cancer and occasionally generates distant metastases. There are few reports of H?rthle cell carcinoma metastases to the vertebral column and none with sacral involvement. Here, we report a 48-year-old woman with a 2-year history of moderate low back pain, alleviated with analgesic medication. Her previous medical files were unremarkable. She performed medical evaluation, and a magnetic resonance of lumbar spine revealed a solitary hypointense T2 lesion on the left lamina of S1. The patient was submitted to percutaneous biopsy that displayed carcinomatous pattern compatible with H?rthle cell carcinoma of thyroid. After that, she was submitted to thyroid ultrasound that showed a nodule. Even in the presence of metastases, patients with H?rthle cell carcinoma usually have a relatively good prognosis. We discuss aspects of the diagnosis, management, and surgical treatment of metastatic H?rthle cell carcinoma in reference to the literature.

show abstract