Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents

Abstract

Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents (N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water.

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…There have been four publications 65,88,154,155 reporting the solubility of mefenamic acid in organic solvents. Lee et al 88 measured the mole fraction solubility of mefenamic acid in cyclohexane, methylbenzene, and ethanol at 298 K. The measurements were performed as part of a larger study that examined the effect that a cosolute had on the solubility of the main solute.…”

“…Mudalip et al 155 measured the solubility of mefenamic acid in three hydrocarbons (hexane, heptane, and cyclohexane), in one alkyl alkanoate (ethyl ethanoate), in two alcohols (ethanol and 2-propanol), and in two miscellaneous organic solvents (N,N-dimethylformamide and N,N-dimethylacetamide) at six different temperatures from 298 to 323 K. The internal consistency of the eight datasets was assessed by curve-fitting the measured mole fraction solubility data to Eq. (8).…”

Characterization and Optimization of Capryol-90, Polysorbate-80, And Peg-400 Proportion in Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) With Simplex-Lattice-Design

“…Mefenamic acid as antiin ammatory non steroid (AINS) drug is used for analgesic to relief headache, toothache, dysmenorrhea, rheumatoid arthritis, osteoarthritis, muscle pain, traumatic and post operation (Mudalip et al, 2013). Mefenamic acid already known asthe most traded drug in middle-income countries and in high-income countries.…”

In vitro characterization and in vivo performance of mefenamic acid-sodium diethyldithiocarbamate based liposomes

“…Mefenamic acid (MFA) is a member of NSAIDs which poses anti-inflammatory, anti-nociceptive, and antipyretic properties (Cimolai, 2013). According to the biopharmaceutical classification system, this drug belongs to class II drugs which are characterized by poor water solubility and low dissolution rate (Abdul Mudalip et al, 2013). The insufficient solubility of MFA usually results in poor bioavailability and gives suboptimaltherapeutic responses.…”

“…The insufficient solubility of MFA usually results in poor bioavailability and gives suboptimaltherapeutic responses. Considerable efforts have been given to enhance MFA water solubility as a key element in improving its bioavailability with little progress (Abdul Mudalip et al, 2013;Imai et al, 1991). L i p o s o m e s a r e d r u g n a n o c a r r i e r s w h i c h basically consist of phospholipids bilayer (s) and pose amphiphilic nature that allows entrapping both hydrophilic and hydrophobic drugs and exhibits multiple biopharmaceutical functions (Bozzuto, Molinari, 2015).…”