Solubility Behavior of Phenolic Compounds in Hexane—ethyl Acetate, Hexane—ethyl Myristate, and Hexane-Ethyl Pivalate Cosolvent Systems

Predictive Relationships for the Effects of Triglyceride Ester Concentration and Water Uptake on Solubility and Partitioning of Small Molecules into Lipid Vehicles

“…The length of side chains determine not only the overall hydrophobicity of the triglyceride but also its molecular weight and volume, and therefore the molar concentration of ester moiety and the overall hydrogen bond accepting propensity of the vehicle. Previous work conducted in this laboratory20 and elsewhere21 as well as existing LFERs suggest that the solvent characteristics of triglycerides vary somewhat systematically with structural features such as degree of unsaturation, chain length, and ester concentration.…”

Quantitative Solubility Relationships and the Effect of Water Uptake in Triglyceride/Monoglyceride Microemulsions

“…Previous work in this laboratory (37,38) and elsewhere (39) suggests that solvent characteristics change systematically with solvent features such as the concentrations of polar fragments. Cao et al (37) applied the linear free energy approach developed by Abraham to obtain solvent coefficients for solvation in tricaprylin/squalane mixtures.…”