Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

Abstract

Solubility of meloxicam in {methanol + water} mixtures from 293.15 to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. A non-linear enthalpy-entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative but variable slopes in the composition region 0.00 < x 1 < 0.60 and variable negative and positive slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by methanol molecules in mixtures 0.31 < x 1 < 1.00.

Solubility, correlation, dissolution thermodynamics and preferential solvation of meloxicam in aqueous mixtures of 2-propanol

“…56 When Eqs. ( 6) and (7) were trained using a minimum number of 7 data points, the MPDs for the predicted meloxicam solubility data points were obtained as 13.6 ± 11.1% and 13.5 ± 10.7 % (N=48), respectively.…”

“…6 Moreover, recently aqueous mixtures with some other cosolvents including choline-based deep eutectic solvents have also been studied. [7][8][9][10] Very good increasing in the meloxicam solubility has been reported reaching more than 1000-fold in some cases.…”

“…Therefore, this research is a continuation of some other similar ones reported earlier for meloxicam solubility in other aqueous cosolvent systems. [6][7][8][9]29 Materials and Methods Materials Meloxicam (Technodrugs & Intermediates PVT LTD, component 3, purity > 0.995 in mass fraction), 2-propanol (Merck, component 1, purity > 0.995 in mass fraction), and distilled water with conductivity < 2 μS•cm -1 (component 2), were used. The chemical suppliers, purities and some other select properties of the reagents are summarized in Table 1.…”

Measurement and modelling of the solubility for ketoconazole in {acetonitrile + water} mixtures at T = (293.2 to 313.2) K

“…Las funciones termodinámicas de mezcla se calcularon de acuerdo con las ecuaciones (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), (1-15) y (1-22), a partir de los valores de entalpía y entropía de solución para el proceso ideal, a la temperatura armónica media.…”

“…Densidad (g cm 0,0 0,9982 0,9970 0,9954 0,9941 0,9924 0,1 1,0304(0,0001) 1,0275(0,0002) 1,0242(0,0001) 1,0207(0,0001) 1,0175(0,0002) 0,2 1,0475(0,0001) 1,0434(0,0001) 1,0393(0,0001) 1,0351(0,0004) 1,0310(0,0001) 0, 3 1,0537(0,0001) 1,0493(0,0001) 1,0450(0,0001) 1,0406(0,0001) 1,0363(0,0001) 0, 4 1,0558(0,0001) 1,0516(0,0001) 1,0474(0,0001) 1,0433(0,0001) 1,0394(0,0002) 0,5 1,0575(0,0008) 1,0541(0,0001) 1,0502(0,0001) 1,0466(0,0001) 1,0430(0,0001) 0,6 1,0585(0,0002) 1,0570(0,0004) 1,0540(0,0001) 1,0513(0,0001) 1,0482(0,0001) 0,7 1,0593(0,0001) 1,0572(0,0002) 1,0556(0,0001) 1,0569(0,0001) 1,0545(0,0001) 0,8 1,0620(0,0002) 1,0606(0,0003) 1,0593(0,0004) 1,0618(0,0001) 1,061(0,0001) 0,9 1,0665(0,0014) 1,0656(0,0012) 1,0653(0,0013) 1,0694(0,0012) 1,0674(0,0013) 1,0 1,0727(0,0029) 1,0708(0,0008) 1,0716(0,0003) 1,0760(0,0003) 1,0735(0,0002) a x1 es la fracción molar de NMP en la mezcla cosolvente libre de soluto; los datos corresponden al valor promedio de tres determinaciones, el valor entre paréntesis corresponde a la desviación estándar.…”