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Solubility of meloxicam in {methanol + water} mixtures from 293.15 to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. A non-linear enthalpy-entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative but variable slopes in the composition region 0.00 < x 1 < 0.60 and variable negative and positive slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by methanol molecules in mixtures 0.31 < x 1 < 1.00.

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