Solubility of meloxicam in (Carbitol® + water) mixtures: Determination, correlation, dissolution thermodynamics and preferential solvation

Tinjacá, Darío A.; Martínez, Fleming; Almanza, Ovidio; Jouyban, Abolghasem; Acree, William E.

doi:10.1016/j.molliq.2020.114671

Cited by 11 publications

(27 citation statements)

References 59 publications

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“…As observed, all the solubility curves exhibit maximum meloxicam solubility in neat methanol. Because the solutes reach their maximum solubilities in solvent systems exhibiting the same polarity [31], it is expected that the meloxicam δ 3 value would be 29.6 MPa 1/2 as the methanol value is at 298.15 K. Nevertheless, this value is lower compared with the one reported (δ 3 = 32.1 MPa 1/2 ) [6][7][8], which was calculated by means of the Fedors' method [32]. As indicated earlier, these discrepancies could be attributed to a specific drug solvation processes by methanol or water, which are not considered in Fedors' calculations [19].…”

Section: Experimental Mole Fraction and Molarity Solubilitymentioning

confidence: 99%

“…The apparent standard Gibbs energies of dissolution of meloxicam in these aqueous mixtures are positive in every case as also are the respective enthalpies of dissolution. Otherwise, the apparent dissolution entropies are negative from neat water to (7) ln X m,T = x 1 1.499 − 3407.179 T + x 2 −10.582 − 924.993 T…”

Section: Apparent Thermodynamic Functions Of Dissolutionmentioning

confidence: 99%

“…Because V 3 values are not available for meloxicam in {methanol (1) + water (2)} mixtures, this property was considered as the same of the pure drug as calculated based on the Fedors' method, i.e. 183.3 cm 3 •mol −1 [6][7][8]. G 1,3 and G 2,3 values shown in Table 8 are negative in all cases, indicating that meloxicam exhibits affinity for bpth methanol and water.…”

Section: Preferential Solvation Analysismentioning

confidence: 99%

“…Moreover, its low aqueous solubility makes difficult the design of liquid medicines of this drug. For these reasons, several investigations have been performed in order to increase its aqueous equilibrium solubility, mainly based in the use of different cosolvents, as has recently been summarized [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

et al. 2021

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Solubility of meloxicam in {methanol + water} mixtures from 293.15 to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. A non-linear enthalpy-entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative but variable slopes in the composition region 0.00 < x 1 < 0.60 and variable negative and positive slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich mixtures but preferentially solvated by methanol molecules in mixtures 0.31 < x 1 < 1.00.

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Section: Experimental Mole Fraction and Molarity Solubilitymentioning

confidence: 99%

Section: Apparent Thermodynamic Functions Of Dissolutionmentioning

confidence: 99%

Section: Preferential Solvation Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

et al. 2021

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“…Las funciones termodinámicas de mezcla se calcularon de acuerdo con las ecuaciones (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), (1-15) y (1-22), a partir de los valores de entalpía y entropía de solución para el proceso ideal, a la temperatura armónica media.…”

Section: Funciones Termodinámicas De Mezcla De MLX En Mezclas Meoh+w Ipoh+w Y Carb+wunclassified

Measurement and modelling of the solubility for ketoconazole in {acetonitrile + water} mixtures at T = (293.2 to 313.2) K

Barzegar-Jalali

Agha

Mirheydari

et al. 2019

Physics and Chemistry of Liquids

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El meloxicam, fármaco semipolar del grupo de los analgésicos no-esteroideos, farmacológicamente posee menos efectos adversos que otros de su grupo, es prácticamente insoluble en agua, limitando su uso en algunas formas farmacéuticas. Como alternativa, la cosolvencia es uno de los medios más poderosos de disolución de solutos no-polares en medio acuoso. Se estudió la solubilidad en nueve sistemas binarios cosolvente-agua en el rango de temperatura entre 293,15 K y 313,15 K, mediante el método de agitación de frasco, para calcular las funciones termodinámicas de disolución, los parámetros de solvatación preferencial a través del método de integrales inversas de Kirkwood-Buff (IKBI), y desafiar ocho modelos matemáticos de cosolvencia. La solubilidad de meloxicam aumenta de manera logarítmica con el aumento de cosolvente en la mezcla, la magnitud de este aumento depende de la naturaleza estructural del cosolvente. Las cantidades termodinámicas obtenidas permiten inferir que los cosolventes trabajan reduciendo las interacciones cohesivas del agua. Las relaciones de compensación entálpica-entrópica en cada sistema fueron no lineales demostrando dos mecanismos de disolución, uno entálpico y el otro entrópico. Las funciones termodinámicas de transferencia de meloxicam desde el agua hasta el cosolvente mostraron que hay diferencias en los mecanismos de disolución de cada sistema. El análisis de solvatación preferencial por medio del método IKBI, demuestra que las mezclas binarias ricas en agua muestran hidratación preferencial, que aumenta con el aumento de la temperatura, mientras que en mezclas intermedias y en mezclas ricas en cosolvente, se evidencia solvatación preferencial por parte del cosolvente. Los perfiles de solvatación preferencial difieren de cosolvente a cosolvente.

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Further calculations on the solubility of trans-resveratrol in (Transcutol® + water) mixtures

Romdhani

Osorio

Martínez

et al. 2021

Journal of Molecular Liquids

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Solubility of meloxicam in (Carbitol® + water) mixtures: Determination, correlation, dissolution thermodynamics and preferential solvation

Cited by 11 publications

References 59 publications

Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

Measurement and modelling of the solubility for ketoconazole in {acetonitrile + water} mixtures at T = (293.2 to 313.2) K

Further calculations on the solubility of trans-resveratrol in (Transcutol® + water) mixtures

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Solubility of meloxicam in (Carbitol® + water) mixtures: Determination, correlation, dissolution thermodynamics and preferential solvation

Cited by 11 publications

References 59 publications

Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

Solubility, Dissolution Thermodynamics and Preferential Solvation of Meloxicam in (Methanol + Water) Mixtures

Measurement and modelling of the solubility for ketoconazole in {acetonitrile + water} mixtures at T = (293.2 to 313.2) K

Further calculations on the solubility of trans-resveratrol in (Transcutol® + water) mixtures

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Product

Resources

About

Solubility of meloxicam in (Carbitol® + water) mixtures: Determination, correlation, dissolution thermodynamics and preferential solvation

Measurement and modelling of the solubility for ketoconazole in {acetonitrile + water} mixtures at T = (293.2 to 313.2) K