Solubility evaluation and thermodynamic modeling of β-lapachone in water and ten organic solvents at different temperatures

Kim, Ki‐Hyun; Oh, Heung‐Bum; Heo, Bora; Kim, Nam Ah; Lim, Dae Gon; Jeong, Seong Hoon

doi:10.1016/j.fluid.2018.05.005

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…However, polarity and dielectric constant are not the only factors responsible for increasing the solubility. Dissolution is a complex phenomenon that can be influenced by other factors including temperature, molecular structure of the drug and solvent, molecular size, solvent–solvent interaction, solute–solvent interaction, co-solvent ratio, and ability to form hydrogen bonding [ 33 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

“…The six different polymers/stabilizers were studied to inhibit drug precipitation while the dissolved drug in THP (solvent) was mixed with water (anti-solvent). Based on the previous studies, polymer screening, polymer ratio, solvent/anti-solvent ratio, and nanosuspension methods were selected [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…The inhibitory effect of polymers on the precipitation of ABN401 was measured using the USP dissolution apparatus 2 (paddle) at 100 rpm using 500 mL of distilled water containing polymers at 0.5% w / v maintained at 37 ± 0.5 °C (Agilent Technologies, Santa Clara, CA, USA). Kollidon ® VA64, Kollidon ® K12, Lutrol ® F127, HPβCD, PEG 6000, and SLS were selected as polymers/stabilizers [ 29 , 33 , 53 ]. The experimental conditions were the same as is mentioned in Section 2.5 .…”

Section: Methodsmentioning

confidence: 99%

“…Recently, THP has been extensively investigated as a co-solvent to enhance solubility of drugs in water co-solvent mixtures [ 3 , 9 , 10 , 11 , 12 ]. THP is a commonly used co-surfactant in the lipid-based formulations, such as the self-microemulsifying drug delivery system (SMEDDS), self-nanoemulsifying drug delivery system (SNEDDS), and nanosuspension [ 29 , 30 , 31 , 32 , 33 ]. Because of its low toxicity, enhanced solubilizing capacity, physiological compatibility, and being listed as excipient in the United States pharmacopoeia national formulary (USP NF), its application in pharmaceutical, cosmeceutical, and nutraceutical field is expanding [ 32 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

et al. 2021

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The solubility and dissolution thermodynamics of new c-Met inhibitor, ABN401, were determined in eleven solvents and Transcutol® HP–water mixture (TWM) from 298.15 to 318.15 K. The experimental solubilities were validated using five mathematical models, namely modified Apelblat, van’t Hoff, Buchowski–Ksiazaczak λh, Yalkowsky, and Jouyban–Acree van’t Hoff models. The experimental results were correlated and utilized further to investigate the feasibility of nanosuspension formation using liquid anti-solvent precipitation. Thermodynamic solubility of ABN401 increased significantly with the increase in temperature and maximum solubility was obtained with Transcutol® HP while low solubility in was obtained water. An activity coefficient study indicated that high molecular interaction was observed in ABN401–Transcutol® HP (THP). The solubility increased proportionately as the mole fraction of Transcutol® HP increased in TWM, which was also supported by a solvent effect study. The result suggested endothermic and entropy-driven dissolution. Based on the solubility, nanosuspension was designed with Transcutol® HP as solvent, and water as anti-solvent. The mean particle size of nanosuspension decreased to 43.05 nm when the mole fraction of ABN401 in THP, and mole fraction of ABN401 in TWM mixture were decreased to 0.04 and 0.1. The ultrasonicated nanosuspension appeared to give comparatively higher dissolution than micronized nanosuspension and provide a candidate formulation for in vivo purposes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

et al. 2021

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“…The research results provide valuable scientific theoretical basis and reference for industrial application in photocatalysis. Kim et al [7] research believes that photocatalytic degradation technology provides a new and practical application value for organic wastewater treatment based on its broad-spectrum applicability and sensitivity to toxic organic compounds. Faleev et al [8] summarizes the pollution status and treatment techniques of persistent organic pollutants (POP) in China's waters, and compares several treatment methods for POP in water.…”

Section: State Of the Artmentioning

confidence: 99%

Thermodynamic analysis of pollution and treatment of organic matter in water

Yan

Guo

2019

THERM SCI

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The problem of environmental pollution is becoming more and more serious with the rapid development of industry and economy, especially the organic matter pollution in water. Thermodynamic analysis method is used based on this to analyze and study the pollution and treatment process of water organic matter in this paper. By proposing that the pollution essence is caused by the uneven distribution of sub-energy, the effect of organic pollutants treatment in four kinds of water bodies in Shenzhen City was analyzed by graphite material adsorption from the perspective of thermodynamic analysis. The experimental results show that the degree of organic pollution in the Jia reservoir of Shenzhen City is from high to low: Dasha River, campus pond, Jia reservoir, and B reservoir. When the ionic strength is 0.04 M, pH is 3.0, graphene loading is 2.5%, and reduced graphene oxide dosage is 200 mg/L, the degradation efficiency of organic pollutants in water is as high as 96.25%.

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Thermodynamic equilibrium of hexamethylenediammonium glutarate in mono-solvents and binary solvent systems

Lü

Chen

Huang

et al. 2019

Fluid Phase Equilibria

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Solubility evaluation and thermodynamic modeling of β-lapachone in water and ten organic solvents at different temperatures

Cited by 10 publications

References 22 publications

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Thermodynamic analysis of pollution and treatment of organic matter in water

Thermodynamic equilibrium of hexamethylenediammonium glutarate in mono-solvents and binary solvent systems

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