Solubility of 6-Chloropyridazin-3-amine in Different Solvents

Cao, Xingjian; Liu, Jinqiang; Lv, Teng-Teng; Yao, Jing-Cai

doi:10.1021/je3001188

Cited by 17 publications

(20 citation statements)

References 13 publications

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“…A laser monitoring observation technique was applied to measure the solubility of the fenofibrate. − The apparatus is the same as that described in a previous study . Predetermined excess amounts of fenofibrate and the solvent of known mass, weighed by an analytical balance (Mettler Toledo AB204-N, Switzerland) with an uncertainty of ±0.0001 g, were placed in a 100 mL jacketed vessel.…”

Section: Methodsmentioning

confidence: 99%

Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Sun

Liu

et al. 2016

J. Chem. Eng. Data

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Solubility of fenofibrate in ethanol−water and acetone−water mixtures was investigated using dynamic laser monitoring at atmospheric pressure and temperatures between 278.15 and 308.15 K. Solubility increased as temperature and the fraction of organics increased. The solubility data was correlated with the modified Apelblat, NRTL, combined nearly ideal binary solvent/Redlich−Kister (CNIBS/R−K), and Jouyban−Acree (J−A) models. Solvent composition and temperature correlations were conducted, and the apparent dissolution enthalpy, entropy, and Gibbs free energy change of the fenofibrate were calculated using the modified Apelblat model and the van't Hoff equation. The results shoLw that the dissolution of fenofibrate is endothermic and nonspontaneous, and that the main contributor in the binary solvents studied is enthalpy.

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Section: Methodsmentioning

confidence: 99%

Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Sun

Liu

et al. 2016

J. Chem. Eng. Data

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“…6 The experimental devices are the same as those described in the previous study. 7 The solubility determination was performed on an 80 mL jacketed vessel with magnetic agitation. The experiments were maintained at a constant temperature by a thermostat (Julabo CF41, Germany).…”

Section: Methodsmentioning

confidence: 99%

Thermodynamic Properties of Form A and Form B of Florfenicol

Sun

Hao

Xie

et al. 2014

Ind. Eng. Chem. Res.

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In this research, a new polymorph of florfenicol (form B) was discovered and successfully prepared. The new polymorph was characterized and identified by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) techniques. It was found that form A has lower melting temperature while higher fusion enthalpy. The solubility of both florfenicol polymorphs in methanol, 2-propanol, acetone, acetonitrile, ethanol, and ethyl acetate were experimentally determined from 278.15 to 318.15 K with a dynamic method. For all tested solvents, the solubility data of florfenicol form B are higher than those of form A. The modified Apelblat model, the NRTL model, and the λh model were adopted to calculate the solubility of florfenicol two forms with satisfactory correlation results. In addition, the dissolution thermodynamic properties of florfenicol form A and form B, including dissolution enthalpy, dissolution entropy, and Gibb's dissolution energy in all tested solvents, were obtained. Combining the results of DCS determination, the solubility, and all the dissolution thermodynamic data, it was confirmed that florfenicol polymorph A and polymorph B belong to the enantiotropic polymorph system.

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“…The mole fraction solubilities ( x ) of DMPO in selected solvents were summarized in Table and plotted as ln x vs temperature in Figure . The temperature dependence of the solubility of DMPO in seven monosolvents is represented by the modified Apelblat equation: − with , where x denotes the mole fraction solubility of DMPO and T (K) is the absolute temperature. Δ fus H 1 (J·mol –1 ) denotes the enthalpy change upon the melting of the solute at its triple-point temperature T t1 (K), Δ fus C p1 (J·K –1 ·mol –1 ) is the difference between the heat capacities of the solute in the liquid and solid phases.…”

Section: Resultsmentioning

confidence: 99%

Solubilities of 1,3,2-Dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide in Selected Solvents between 278.15 K and 343.15 K

et al. 2015

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The mole fraction solubilities of 1,3,2-dioxaphosphorinane-2methanol-α,5,5-trimethyl-α-phenyl-2-oxide in different organic solvents including acetonitrile, acetone, ethyl acetate, 1,2-dichloroethane, methanol, ethanol, and chloroform were measured at a designated temperature range of (278.15 to 343.15) K and at atmospheric pressure by the gravimetrical method. The compound's structure and thermal stability were characterized by infrared spectroscopy, nuclear magnetic resonance ( 1 H NMR and 31 P NMR), mass spectroscopy, elemental analysis, and thermogravimetric analysis. The mole fraction solubilities of 1,3,2-dioxaphosphorinane-2-methanol-α,5,5-trimethyl-αphenyl-2-oxide in the above-mentioned organic solvents were correlated as the Apelblat equation, and the calculated values with equations showed good consistency with the experimental values. The root-mean-square deviation was less than 0.010 % and the average relative error was less than 0.11 % in all the experiments.

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Solubility of 6-Chloropyridazin-3-amine in Different Solvents

Cited by 17 publications

References 13 publications

Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Thermodynamic Properties of Form A and Form B of Florfenicol

Solubilities of 1,3,2-Dioxaphosphorinane-2-methanol-α,5,5-trimethyl-α-phenyl-2-oxide in Selected Solvents between 278.15 K and 343.15 K

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