Solubility of chlorpheniramine maleate in supercritical carbon dioxide

Lashkarbolooki, Mostafa; Hezave, Ali Zeinolabedini; Rahnama, Yaghoub; Rajaei, Hamid; Esmaeilzadeh, Feridun

doi:10.1016/j.supflu.2013.09.007

Cited by 21 publications

(8 citation statements)

References 44 publications

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“…4 revealed that as the temperature increases, the used correlation especially KJ model are less able to predict the behavior of the measured solubility data at the elevated temperatures. This observed trend which was previously observed for other pharmaceuticals [40][41][42][43], was reported at first by Kurnik and Reid [44]. In detail, At the high pressures, the density of the of compressed carbon dioxide moves toward a value of 972.3 kg m À3 which is not so far away from water at ambient conditions can lead to a phenomenon called "squeezing out".…”

Section: Resultssupporting

confidence: 76%

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Khayyat

Kashkouli

Esmaeilzadeh

2015

Fluid Phase Equilibria

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Section: Resultssupporting

confidence: 76%

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Khayyat

Kashkouli

Esmaeilzadeh

2015

Fluid Phase Equilibria

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“…C' is the BET constant. The data found through the BET, BJH and the adsorption/desorption isotherm methods demonstrate the crosssectional area, total pore volumes, and dead volume calculated, respectively, as 0.162 nm 2 , 0.0439 cm 3 g À1 and 15.972 cm3 . Also, the mean pore diameter was calculated at 20.33 nm with BET isotherm data.TGA results of the Li/Al NPs functionalized with GOQDs are illustrated in Figure 7a.…”

mentioning

confidence: 75%

“…[1] CPAM is a homologous biological agent that is effective in local immune responses, regulates the physiological function of the intestine and acts as a neurotransmitter in the nervous system. [2,3] The most common problem when using CPAM is low solubility in aqueous medium and controlled release, [4,5] Scheme 1a shows all functional groups in chlorpheniramine maleate structures. In recent years, nanoparticles especially nanocarriers have developed the solubility of conventional drug delivery systems such as polymers, [6,7] liposomes, and emulsions nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Eco‐friendly synthesis of the Li/Al in nonionic surfactant‐based vesicles (niosomes) modified with graphene oxide quantum dot nanostructures for controlled released of chlorpheniramine maleate

2021

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The aim of the present work was the preparation of Li/Al nanoparticles (NPs) functionalized with graphene oxide quantum dots (GOQDs) for the controlled release of chlorpheniramine maleate (CPAM). The role of lemon and egg white extracts as oxidation agents were investigated for the morphology and particle size of the products. GOQDs were synthesized using green, environmentally friendly, and cost-effective precursors. This work demonstrates that Li/Al NPs functionalized with graphene oxide as a nanolayer structure can be used as efficient nanocarriers for loading and delivery of CPAM as water-insoluble aromatic drugs The final products were identified with X-ray diffraction, scanning electron microscopy, atomic force microscopy, ultraviolet-visible spectroscopy, dynamic light scattering, thermogravimetric analysis, and transmission electron microscopy nitrogen adsorption [i.e. Brunauer-Emmett-Teller (BET) surface area analysis] techniques. The calibration curve for Li/Al nanoparticles functionalized with GOQDs for controlled released of CPAM was calculated as y = 0.0137x + 0.0103 with R 2 = 0.9995. The data found through BET and Barrett-Joyner-Halenda analysis using the adsorption/ desorption isotherm method demonstrated by total pore volumes and dead volume were calculated respectively as 0.162 nm 2 , 0.0439 cm 3 g À1 . The mean pore diameter was calculated as 20.33 nm using BET isotherm data.

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“…Knowing the solubility of pharmaceuticals in SC carbon dioxide is highly required for industrializing the SC-CO 2 -based processes . Solubility data not only can help to optimize the process yield, rate, design, and cost but also, knowing the drug solubility, can help the researchers to pre-evaluate the important characteristics of the drug particles, including size, surface structure, and morphology of products. − In light of these facts and requirements, the solubility of different substances in SC-CO 2 has been measured under different pressures and temperatures during the past two decades. − …”

Section: Introductionmentioning

confidence: 99%

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

et al. 2020

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In the current investigation, the solubility of fenoprofen as a nonsteroidal anti-inflammatory drug in supercritical CO2 (SC-CO2) is measured by employing a motorized PVT (pressure–volume–temperature) equilibrium cell. The solubility measurements were carried out in temperatures between 308 and 338 K and pressures between 12 and 40 MPa. The measured data reveals that the solubility of fenoprofen (mole fraction) lies between 2.01 × 10–5 and 4.20 × 10–3, depending on the thermodynamic conditions. Besides the experimental measurement of fenoprofen solubility, thermodynamic modeling of solubility using five different density-based semi-empirical correlations was carried out. The models were considered with only three fitting parameters, namely, Mendez-Santiago and Teja (MST), Bartle et al., Kumar and Johnston (K–J), Chrastil, and Garlapati and Madras models. The results revealed that among the examined models, the Bartle et al. model was the most accurate one with the lowest average absolute relative deviation percent (AARD %) of 6.58% for the studied drug, while the K–J model leads to poor prediction with an AARD % of 9.60%.

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Solubility of chlorpheniramine maleate in supercritical carbon dioxide

Cited by 21 publications

References 44 publications

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Solubility of fluvoxamine maleate in supercritical carbon dioxide

Eco‐friendly synthesis of the Li/Al in nonionic surfactant‐based vesicles (niosomes) modified with graphene oxide quantum dot nanostructures for controlled released of chlorpheniramine maleate

Experimental Solubility Measurements of Fenoprofen in Supercritical Carbon Dioxide

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