Solubility of I-653, Sevoflurane, Isoflurane, and Halothane in Human Tissues

Yasuda, Nobuhiko; Targ, Alexander G.; Eger, Edmond I.

doi:10.1213/00000539-198909000-00016

Cited by 217 publications

(103 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite those times having presented statistically significant differences, the values observed are within those mentioned by other studies [10][11][12] .…”

Section: Discussionsupporting

confidence: 88%

Estudo comparativo duplamente encoberto entre Sevoflurano Genérico e Sevorane®

Portella¹,

Laurencel²,

Rosa³

et al. 2010

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

Summary: Portella AAV, Laurencel SM, Rosa DM, Rivera MIM, Quintero SO -A Double-Blind Comparative Study between Generic Sevoflurane and Sevorane TM . Background and objectives:Sevoflurane is presented in three types of vials. The differences in physical-chemical properties of those products are due to different manufacturing processes, although they are essentially identical regarding chemical comparison tests. It has been hypothesized that the Sevoflurane molecule could present chemical instability due to the formation of Lewis acids as a consequence of the materials used in the fabrication of the vials and the water content. The objective of this study was to analyze the clinical efficacy of Sevoflurane conditioned in different vials.

show abstract

“…Despite those times having presented statistically significant differences, the values observed are within those mentioned by other studies [10][11][12] .…”

Section: Discussionsupporting

confidence: 88%

Estudo comparativo duplamente encoberto entre Sevoflurano Genérico e Sevorane®

Portella¹,

Laurencel²,

Rosa³

et al. 2010

Rev. Bras. Anestesiol.

View full text Add to dashboard Cite

show abstract

“…3 The volatile anesthetics, desflurane and sevoflurane, have significantly lower blood/gas partition coefficients (0.45 and 0.65, respectively) compared with isoflurane (1.4) or halothane (2.4), predicting greater intraoperative control and more rapid recovery from anesthesia. 4,5 More rapid recovery might be associated with earlier maintenance of patent airways, more effective protection against aspiration, and greater oxygenation. 6 Studies of healthy volunteers have indicated that recovery from anesthesia with desflurane is faster than that with sevoflurane.…”

Section: Résumémentioning

confidence: 99%

Postoperative recovery after anesthesia in morbidly obese patients: a systematic review and meta-analysis of randomized controlled trials

Liu

Cherng

Chen

et al. 2015

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

Purpose Obese patients present a challenge to safe general anesthesia because of impaired cardiopulmonary physiology and increased risks of aspiration and acute upper airway obstruction. Since studies are lacking regarding the postoperative effects on recovery from general anesthesia in morbidly obese patients, we conducted a systematic review and meta-analysis of recovery outcomes in morbidly obese patients who had undergone general anesthesia.Source We systematically searched the PubMed, EMBASE TM , Cochrane, and Scopus TM databases for randomized controlled trials that evaluated the outcome of anesthesia with desflurane, sevoflurane, isoflurane, or propofol in morbidly obese patients. Using a random effects model, we conducted meta-analyses to assess recovery times (eye opening, hand squeezing, tracheal extubation, and stating name or birth date), time to discharge from the postanesthesia care unit (PACU), and the incidence and severity of postoperative nausea and vomiting (PONV). Principal findings We reviewed results for 11 trials and found that patients given desflurane took less time: to respond to commands to open their eyes (weighted mean difference [WMD] -3.10 min; 95% confidence interval (CI): -5.13 to -1.08), to squeeze the investigator's hand (WMD -7.83 min; 95% CI: -8.81 to -6.84), to be prepared for tracheal extubation (WMD -3.88 min; 95%

show abstract

“…2 Additionally, sevoflurane provides smooth volatile induction due to its lack of airway irritation, and it is often used as an induction agent. [3][4][5] Desflurane has the lowest solubility of currently available volatile anesthetics, 6 which may allow for more rapid emergence and recovery than sevoflurane. 7 Additionally, the use of desflurane is associated with more predictable emergence and recovery than sevoflurane.…”

Section: Résumémentioning

confidence: 99%