Solubility of Ibuprofen, Phytosterol, Salicylic Acid, and Naproxen in Aqueous Solutions

Bolten, Dennis; Lietzow, R.; Türk, Michael

doi:10.1002/ceat.201200510

Cited by 20 publications

(16 citation statements)

References 27 publications

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“…Various techniques for IBP solubilization in solid oral formulations have been described in the literature: lipid based drug delivery system (8), solid lipid nanoparticles or spray drying of amorphous IBP nanoparticles for the production of granules with enhanced drug release (9,10), solubilization by surfactants (7,11), solid dispersion techniques (12,13), fusion method with Poloxamer 407 (14) and also freeze drying to form IBP crystals (15) or for orodispersible tablet (ODT) formulation (16). The approaches described for liquid formulations are mainly focused on solubility enhancement by cyclodextrin complexation (17,18), addition of hydrotropic agents (19), pH modification (7), surfactant and cosolvent addition (20)(21)(22) and salt formation (23,24).…”

Section: Mirjana Gašperlinmentioning

confidence: 99%

Solubilization of ibuprofen for freeze dried parenteral dosage forms

et al. 2018

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Ibuprofen, a weakly acidic non-steroidal anti-inflammatory drug having poor aqueous solubility, is a challenging drug for the development of pharmaceutical formulations, resulting in numerous research attempts focusing on improvement of its solubility and consequently bioavailability. Most studies have been done for solid dosage forms, with very little attention paid to parenterals. Hence, the main purpose of the present study was to enhance ibuprofen solubility as a result of formulation composition and the freeze drying process. Moreover, the purpose was to prepare a freeze dried dosage form with improved ibuprofen solubility that could, after simple reconstitution with water for injection, result in an isotonic parenteral solution. Solubility of ibuprofen was modified by various excipients suitable for parenteral application. Drug interactions with selected excipients in the final product/lyophilisate were studied by a combined use of XRPD, DSC, Raman and ss-NMR. Analyses of lyophilized samples showed solubility enhancement of ibuprofen and in situ formation of an ibuprofen salt with the alkaline excipients used.

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Section: Mirjana Gašperlinmentioning

confidence: 99%

Solubilization of ibuprofen for freeze dried parenteral dosage forms

et al. 2018

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“…The solubility of ASA and SAA/4,4′‐bipy cocrystals was investigated in order to assess stability regions of SAA/4,4′‐bipy cocrystals in aqueous solutions 20. The solubilities of pure substances, physical mixture, and cocrystals in ethanol at various temperatures are depicted in Fig.…”

Section: Resultsmentioning

confidence: 99%

Formation of Salicylic Acid/4,4′‐Dipyridyl Cocrystals Based on the Ternary Phase Diagram

2015

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The solubility behavior of salicylic acid (SAA)/4,4 -dipyridyl (4,4 -dipy) cocrystals is investigated in an ethanol solvent. The phase solubility diagram (PSD) of SAA/4,4 -dipy cocrystals is determined which are formed in a 2:1 stoichiometric ratio in ethanol. The objective is to improve the fundamentals of the formation mechanisms, solution behavior, and solid-state properties of SAA/4,4 -dipy cocrystals. The solubility behavior and solution chemistry of cocrystals are studied. It was found that the thermodynamic stability regions of the cocrystals and its components are defined by the phase solubility diagram. Besides the kinetic also the thermodynamic factor turned out to be important for the crystallization of cocrystals.

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“…SA (Carl Roth, ≥ 99 %) has a low water solubility of about 2.2 g dm −3 12 which allows for application of these crystals, e.g., to encapsulate agents for water‐based cosmetics. The crystallization process was based on an antisolvent method from methanolic solution (methanol from Overlack, ≥ 99 %) with deionized water as antisolvent.…”

Section: Experimental Methodsmentioning

confidence: 99%

Generation of Crystalline Microcontainers of Salicylic Acid

Seidel

Ulrich

2015

Chem Eng & Technol

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The formation of liquid inclusions is frequently observed to be disrupting in crystallization processes. But such crystals containing liquid inclusions might offer the possibility to be used as container systems by encapsulating other substances inside the inclusions. Experimental parameters to generate such microcontainer systems, i.e., crystals including liquid inclusions, of salicylic acid by means of antisolvent crystallization were investigated. It was shown that concentration, addition rate of the antisolvent, and gas content of the liquids related to the temperature have a distinct influence on the size of the formed inclusions.

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Solubility of Ibuprofen, Phytosterol, Salicylic Acid, and Naproxen in Aqueous Solutions

Cited by 20 publications

References 27 publications

Solubilization of ibuprofen for freeze dried parenteral dosage forms

Solubilization of ibuprofen for freeze dried parenteral dosage forms

Formation of Salicylic Acid/4,4′‐Dipyridyl Cocrystals Based on the Ternary Phase Diagram

Generation of Crystalline Microcontainers of Salicylic Acid

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