Solubility of minoxidil in binary mixture of ethanol + water at various temperatures

Mirzaeei, Shahla; Pirhayati, Faezeh H.; Mohammadi, Ghobad; Rahimpour, Elaheh; Martínez, Fleming; Jouyban, Abolghasem

doi:10.1080/00319104.2018.1528596

Cited by 25 publications

(6 citation statements)

References 27 publications

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“…However, to ensure the accuracy of the fitted parameters and the reliability of esculetin solubility data, it is imperative to conduct further verification by assessing the RAD and RMSD between the actual solubility data ( x exp ) and the corresponding calculated data ( x cal ) . The calculation formulas for RAD and RMSD are expressed as eqs , – R A D = 1 N ∑ i = 1 N true| x exp .25em − .25em x normalc normala normall x exp true| R M S D = true[ 1 N ∑ i = 1 N false( x normalc normala normall − x exp false) 2 true] 1 / 2 …”

Section: Resultsmentioning

confidence: 99%

“…The analysis of esculetin solubility in pure solvents involved the application of the Modified Apelblat model and the λ h model for data fitting. Additionally, we explored esculetin solubility using three distinct thermodynamic models: the CNIBS/R-K model, the Jouyban–Acree–van’t Hoff model, and the SUN model. − Our objective was to examine the relationship between temperature and the molar composition of binary solvents. To assess the impact of solvent properties on solubility, we employed the KAT-LSER model.…”

Section: Thermodynamic Modelsmentioning

confidence: 99%

“…Temperature plays a pivotal role in shaping the solubility of substances, but the CNIBS/R-K model lacks precision in illustrating their interdependence. Employing the Jouyban–Acree–van’t Hoff model provides a more accurate portrayal of how temperature and solvent ratios impact solubility. − The model is characterized by – ln nobreak0em0.25em⁡ x = x A ln nobreak0em0.25em⁡ X A + x B ln nobreak0em0.25em⁡ X B + x A x B ∑ i = 0 N J i false( x A .25em − .25em x B false) i T …”

Section: Thermodynamic Modelsmentioning

confidence: 99%

“…My research focuses on the effects of quercetin solubility in different solvents, at different temperatures, and at different molar ratios. Furthermore, the research involved the examination of the experimental data using five commonly utilized thermodynamic models: the Modified Apelblat model, the λ h model, the CNIBS/R-K model, the Jouyban–Acree–van’t Hoff model, and the SUN model, and the KAT-LSER model was utilized to assess how the chemical properties of ten individual solvents affect the solubility of esculetin. − This was done to evaluate and compare the accuracy of the experimental data across these models.…”

Section: Introductionmentioning

confidence: 99%

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Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Yang,

Yan,

Huang

et al. 2024

J. Chem. Eng. Data

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Esculetin is derived from the leaves of lemons of Rutaceae and the bark of bittersweet ash, belladonna, mandala, and Rehmannia plants. In this research, the solubility of esculetin in ten solvents such as ethyl acetate, isobutyl alcohol, water, methanol, acetonitrile, n-propyl alcohol, isopropyl alcohol, n-butanol, ethanol, and acetone was determined by utilizing static equilibrium-high performance liquid chromatography (HPLC) under standard atmospheric pressure conditions and temperatures in the range of 273.15 to 318.15 K. Among the above ten pure solvents, water displayed the least solubility, while methanol exhibited the highest solubility. At the same temperature (T = 273.15 ∼ 318.15 K), the solubility of esculetin increased with the increase of the molar ratio of soluble solvents. Similarly, when the temperature increases (T = 273.15 ∼ 318.15 K), the solubility of the three binary solvents increases under the condition of a constant molar ratio. The above results suggest that the main factor affecting the solubility of esculetin in the solvent may be the polarization/bipolarity of the solvent. The experimental data was fitted by five thermodynamic models (the Buchowski−Ksiazaczak λh model, the Modified Apelblat model, the Jouyban−Acree model, the SUN model, and the CNIBS/R-K model), and the relative average deviation and root-mean-square deviation of the data were calculated, which proved that the correlation of the solubility data and the five models was relatively good. XRD and DSC were used to detect the crystal form and stability of esculetin during the experiment.

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Section: Resultsmentioning

confidence: 99%

Section: Thermodynamic Modelsmentioning

confidence: 99%

Section: Thermodynamic Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Yang,

Yan,

Huang

et al. 2024

J. Chem. Eng. Data

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“…In this work, we in-depth investigated the behavior of allopurinol in several solvent mixtures, in order to test the influence of medium and polarity of the co-solvents selected (solubility parameters δ 1 from 14.93 MPa 1/2 to 47.8 MPa 1/2 ). Data in solvent mixtures have served to test the prediction models for non-polar solutes in non-aqueous solvent mixtures [7][8][9][10][11]. Aqueous mixtures are of particular interest for pharmaceutical industry.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Analysis for the Solubility of Allopurinol in Aqueous and Non-aqueous Mixtures at Various Temperatures

et al. 2022

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The solubility of allopurinol was measured at several temperatures (15–35 ºC) in ethanol–water, ethanol–ethyl acetate, and ethyl acetate–hexane mixtures. The mole fraction solubility shows two solubility maxima against the co-solvent (ethanol) ratio (70 % ethanol–water and 100 % ethyl acetate) at each of the five temperatures studied. The authors correlated the solubility data in binary solvent mixtures at various temperatures using a modified version of the Jouyban–Acree model. The respective apparent thermodynamic functions Gibbs energy, enthalpy, and entropy of solution were obtained from the solubility data through the van’t Hoff equations. The apparent enthalpies of solution are endothermic and display a maximum at 20 % ethanol in water, as ethanol is added to water, the entropy of the system increases. In the non-aqueous mixture (ethanol–ethyl acetate), enthalpy is the driving force throughout the whole solvent composition. An enthalpy–entropy compensation analysis confirms a non-linear enthalpy–entropy relationship in plots of enthalpy vs. Gibbs energy of solution, i.e., two different mechanisms involved in the solubility enhancement. An inverse Kirkwood–Buff integral analysis of the preferential solvation indicated that in ethanol-rich mixtures, the drug is preferentially solvated by water, and it is acting mainly as a Lewis base in front to water.

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Effective Removal of Beryllium from Industrial Wastewater by Alkali-Leaching Activated Carbon

Zhao,

Zheng,

Xia

et al. 2023

Water Air Soil Pollut

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Solubility of minoxidil in binary mixture of ethanol + water at various temperatures

Cited by 25 publications

References 27 publications

Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Solubility Determination and Thermodynamic Model Analysis of Esculetin in Different Solvents from 273.15 to 318.15 K

Thermodynamic Analysis for the Solubility of Allopurinol in Aqueous and Non-aqueous Mixtures at Various Temperatures

Effective Removal of Beryllium from Industrial Wastewater by Alkali-Leaching Activated Carbon

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