Solubility of naproxen in ternary mixtures of {ethanol + propylene glycol + water} at various temperatures: Data correlation and thermodynamic analysis

Asghar, Samira Zadali; Jouyban, Abolghasem; Martínez, Fleming; Rahimpour, Elaheh

doi:10.1016/j.molliq.2018.07.082

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…Moreover, positive

indicated that molecular interaction between the drug and solvents was stronger and required higher energies for breaking solute–solute and solvent–solvent intermolecular interaction [ 12 ]. Similarly, the decreased value of

indicates that the dissolution process is more favorable in the solvents with high solubility [ 25 ]. It was found that the

values were the highest in water and the lowest in THP, owing to the highest solubility of the drug in THP and the lowest solubility in water among the solvents.…”

Section: Resultsmentioning

confidence: 99%

“…Co-solvency or solvent mixing helps in estimating the preferential solvation of solute by the solvent compounds in mixtures [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Various co-solvents such as methanol, ethanol, polyethylene glycol (PEG) 400, acetone, ethyl acetate, dimethyl acetamide (DMA), dimethyl formamide (DMF), N -methyl-2-pyrrolidone (NMP), and dimethyl sulfoxide (DMSO) have been used to enhance the solubility of drugs [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Methanol, acetonitrile, DMA, DMF, and NMP fall under class 2 solvents while ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, and ethyl acetate fall under class 3 solvents [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

et al. 2021

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The solubility and dissolution thermodynamics of new c-Met inhibitor, ABN401, were determined in eleven solvents and Transcutol® HP–water mixture (TWM) from 298.15 to 318.15 K. The experimental solubilities were validated using five mathematical models, namely modified Apelblat, van’t Hoff, Buchowski–Ksiazaczak λh, Yalkowsky, and Jouyban–Acree van’t Hoff models. The experimental results were correlated and utilized further to investigate the feasibility of nanosuspension formation using liquid anti-solvent precipitation. Thermodynamic solubility of ABN401 increased significantly with the increase in temperature and maximum solubility was obtained with Transcutol® HP while low solubility in was obtained water. An activity coefficient study indicated that high molecular interaction was observed in ABN401–Transcutol® HP (THP). The solubility increased proportionately as the mole fraction of Transcutol® HP increased in TWM, which was also supported by a solvent effect study. The result suggested endothermic and entropy-driven dissolution. Based on the solubility, nanosuspension was designed with Transcutol® HP as solvent, and water as anti-solvent. The mean particle size of nanosuspension decreased to 43.05 nm when the mole fraction of ABN401 in THP, and mole fraction of ABN401 in TWM mixture were decreased to 0.04 and 0.1. The ultrasonicated nanosuspension appeared to give comparatively higher dissolution than micronized nanosuspension and provide a candidate formulation for in vivo purposes.

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“…Moreover, positive

indicates that the dissolution process is more favorable in the solvents with high solubility [ 25 ]. It was found that the

values were the highest in water and the lowest in THP, owing to the highest solubility of the drug in THP and the lowest solubility in water among the solvents.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

et al. 2021

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“…Moreover, positive ∆H • sol indicated that the molecular interactions between GLN and the solvents was stronger and required higher energies for breaking solute-solute and solvent-solvent intermolecular interactions [35]. Similarly, the decreased value of ∆G • sol indicates that the dissolution process is more favorable in the solvents with high solubility [16]. It was found that the ∆G 9) [21].…”

Section: Apparent Thermodynamic Analysismentioning

confidence: 99%

“…Generally, a solvent mixture could contribute to the preferential solvation of the solute [14,15]. Different solvent mixtures such as methanol, ethanol, polyethylene glycol (PEG) 400, acetone, DMF, ethyl acetate, DMA, NMP, and DMSO have all been used to enhance the drug solubility [16,17]. One of the studies reported GLN solubility in NMP + water, propylene glycol + water, and PEG 400 + water mixtures [18,19].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Solubility Thermodynamics of Glibenclamide with Recrystallization and In Vitro Release Profile

et al. 2022

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The solubility of glibenclamide was evaluated in DMSO, NMP, 1,4-dioxane, PEG 400, Transcutol® HP, water, and aqueous mixtures (T = 293.15~323.15 K). It was then recrystallized to solvate and compressed into tablets, of which 30-day stability and dissolution was studied. It had a higher solubility in 1,4-dioxane, DMSO, NMP (Xexp = 2.30 × 103, 3.08 × 104, 2.90 × 104) at 323.15 K, its mixture (Xexp = 1.93 × 103, 1.89 × 104, 1.58 × 104) at 298.15 K, and 1,4-dioxane (w) + water (1−w) mixture ratio of w = 0.8 (Xexp = 3.74 × 103) at 323.15 K. Modified Apelblat (RMSD ≤ 0.519) and CNIBS/R-K model (RMSD £ 0.358) suggested good comparability with the experimental solubility. The minimum value of ΔG˚ vs ΔH˚ at 0.70 < < 0.80 suggested higher solubility at that molar concentration. Based on the solubility, it was recrystallized into the solvate, which was granulated and compressed into tablets. Among the studied solvates, the tablets of glibenclamide dioxane solvate had a higher initial (95.51%) and 30-day (93.74%) dissolution compared to glibenclamide reference (28.93%). There was no stability issue even after granulation, drying, or at pH 7.4. Thus, glibenclamide dioxane solvate could be an alternative form to improve the molecule’s properties.

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“…Etanol, gliserin dan propilen glikol adalah pelarut yang umum digunakan dalam bidang farmasi [25] . Kosolvensi merupakan metode yang sangat sederhana dan efektif, banyak digunakan untuk meningkatkan kelarutan obat yang kurang larut [23,26] .…”

Section: Pendahuluanunclassified

Peningkatan Kelarutan Fisetin Dengan Teknik Kosolvensi

Dzakwan

Priyanto

2019

JIPP

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Fisetin adalah senyawa flavonoid yang memiliki beragam aktivitas, salah satunya adalah sebagai antioksidan. Fisetin memiliki kelarutan dan bioavailabilitas yang rendah sehingga penerapannya terbatas untuk oral dan dermal. Tujuan penelitian adalah meningkatkan kelarutan fisetin dengan metode kosolvensi menggunakan tiga pelarut berbeda, yaitu air, etanol dan propilen glikol dengan berbagai konsentrasi. Hasil penelitian menunjukkan kelarutan fisetin meningkat signifikan sebesar 206.002 ± 0,014 mg / mL dengan penambahan campuran pelarut air, etanol dan propilen glikol (60: 25: 15% v/v). Campuran pelarut yang kurang polar dapat meningkatkan kelarutan obat melalui mekanisme interaksi hidrofobik. Campuran pelarut air-etanol-propilen glikol (60: 25: 15% v / v) menunjukkan potensi pelarutan tertinggi

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Solubility of naproxen in ternary mixtures of {ethanol + propylene glycol + water} at various temperatures: Data correlation and thermodynamic analysis

Cited by 13 publications

References 21 publications

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Correlation of Solubility Thermodynamics of Glibenclamide with Recrystallization and In Vitro Release Profile

Peningkatan Kelarutan Fisetin Dengan Teknik Kosolvensi

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Solubility of naproxen in ternary mixtures of {ethanol + propylene glycol + water} at various temperatures: Data correlation and thermodynamic analysis

Cited by 13 publications

References 21 publications

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Solubility Determination of c-Met Inhibitor in Solvent Mixtures and Mathematical Modeling to Develop Nanosuspension Formulation

Correlation of Solubility Thermodynamics of Glibenclamide with Recrystallization and In Vitro Release Profile

Peningkatan Kelarutan Fisetin Dengan Teknik Kosolvensi

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Solubility of naproxen in ternary mixtures of {ethanol + propylene glycol + water} at various temperatures: Data correlation and thermodynamic analysis