Solubility of sulfadiazine in (ethylene glycol + water) mixtures: Measurement, correlation, thermodynamics and preferential solvation

Cruz-González, Ana María; Vargas-Santana, Martha Sofía; Ortíz, Claudia Patricia; Cerquera, Néstor Enrique; Delgado, Daniel Ricardo; Martínez, Fleming; Jouyban, Abolghasem; Acree, William E.

doi:10.1016/j.molliq.2020.115058

Cited by 13 publications

(1 citation statement)

References 55 publications

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“…It is then understandable that many experiments are carried out in order to quantify this solubility in different solvents. Such efforts are undertaken also in the field of sulfonamides and one can include here the works of Delgado et al [5][6][7][8][9], Cruz et al [10], Kodide et al [11], Martínez et al [12,13], Romdhani et al [14], and Blanco et al [15][16][17]. Alongside the experimental measurements, many theoretical solubility models have been developed for accurate prediction of solubility and for better understanding of the interactions occurring in solute-solvent systems [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Prediction of sulfamerazine and sulfamethazine solubility in some cosolvent mixtures using non-ideal solution models

Tinoco

Galindres

Osorio

et al. 2021

Rev. Colomb. Cienc. Quím. Farm.

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Introduction: Experimental Solubilities of sulfamerazine (SMR) and sulfamethazine (SMT) in some (methanol + water), (ethanol + water) and (1-propanol + water) cosolvent mixtures were collected from the literature at five temperatures from 293.15 to 313.15 K. Methodology: The results were analyzed with the van’t Hoff, Apelblat modified, Buchowski-Ksiazaczak λh, van’t Hoff-Yaws model, twoparameter Weibull function model. It was determined that the models that best describe the solubility of these sulfonamides in (alcohol + water) mixtures were thevan’t Hoff and Apelblat models, obtaining correlation indices greater than 0.99 in all cases. Results: The results obtained with the Modified Apelblat equation presents ahigh correlation index for the solubility of SMR and SMT in cosolvent mixtures, followed by the van’t Hoff-Yaws model that presents a high fit of the estimated data with respect to the theoretical ones. According to the two parameter Weibull function model, the solubility of SMR and SMT in the co-solvent mixtures shows important deviations from ideality, which is consistent with the literature. The results are discussed in terms of the solute-solvent interactions that occur in this system.

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