Solubility of β-Artemether in Methanol + Water and Ethanol + Water from (288.85 to 331.95) K

Abstract

The solubility of β-artemether in methanol + water and ethanol + water was measured over the temperature range from (288.85 to 331.95) K under atmospheric pressure using a gravimetric method. The experimental data were satisfactorily correlated with a modified empirical logarithmic equation. The experimental solubility data show good agreement with the calculated values. The relative average deviations (RADs) between the experimental and calculated values are less than 3 %.

Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of β-artemether in the mixture of ethanol and water

“…In this study, A sat was calculated from the literature (Zhang et al, 2009). MSZW of the ␤-artemether solution at different experimental conditions are given in Table 2.…”

“…For this important API, crystallization is often used as a key purification process for quality control (Zhang et al, 2009) in its production, but chemical engineering research and design x x x ( 2 0 1 4 ) xxx-xxx Greek symbols j jth moment of population balance function constant coefficient [Eqs. (1) and (20) (Barrett et al, 2010;Feng and Berglund, 2002;Lewiner et al, 2001;Yang and Nagy, 2013).…”

Solubility of 2,5-Di-tert-butylhydroquinone and Process Design for Its Purification Using Crystallization

“…Relative average deviation (RAD) was calculated using eq to assess the accuracy of models developed. The relative deviation (RD) between experimental data and predictions was also calculated using eq . The thermodynamic model with the lowest RD and RAD are preferred. where x 1 is the measured mole fraction solubility data, x 1 fit is the fitted mole fraction solubility by the models, and n is the total number of experimental points in different solvents.…”

On-line concentration measurement for anti-solvent crystallization of β-artemether using UV–vis fiber spectroscopy

“…Crystallization is the key purification process for the quality control of b-artemether [12]. Usually ethanol is selected as solvent and water is used as anti-solvent.…”

“…The solubility data of b-artemether in water-ethanol system can be obtained from [12], and all calibration experiments are conducted in desaturated situation to avoid the occasionally nucleation phenomena. Three UV spectra were taken for each experiment, and the average value was used as the final raw UV spectrum.…”